Senior Director, Global Program Development Lead - DMD/Neuromuscular

The opportunity

As a Senior Director, Global Program Development Lead (PDL), you will be in a highly visible leadership role that sits at the center of the cross-functional program team, to shape a compelling strategic direction, set ambitious priorities, and drive disciplined execution, in partnership with senior leadership. Leveraging deep expertise in drug development and commercialization, along with a forward-looking perspective and strong operational mindset, you will ensure the program team operates with clarity, rigor, and urgency while fostering collaboration and high performance. Accountable for cross-functional outputs, you'll guide the program’s path forward by anticipating opportunities, mitigating risks, cultivating strategic options, and driving decision-making amid complexity and uncertainty to achieve long-term program success.

What you'll be doing

• Lead overall program strategy, accountable for an integrated Program Development Strategy, Target Product Profile (TPP), and lifecycle management plan aligned with corporate objectives and long-term portfolio goals to maximize asset value.
• Drive cross-functional strategic integration, ensuring scientific rigor and emerging clinical data, competitive intelligence, and evolving market dynamics inform program direction and critical decisions.
• Identify key development challenges and define strategic options across functions, including timelines, budgets, risks, and trade-offs, enabling timely, high-quality decision-making.
• Support business development activities, including opportunity assessment and due diligence; represent the program on Joint Steering Committees for partnered assets.
• Maintain external perspective and scientific credibility through engagement with KOLs, patient advocacy groups, and other external experts.
• Evolving and maturing the program’s external communications strategy in partnership with key groups, including the elements of scientific messaging, competitive positioning, and stakeholder alignment.
• Drive cross-functional program execution within a matrix organization, ensuring high-quality, on-time deliverables while aligning priorities and resources to maximize program value and proactively resolve critical challenges.
• Anticipate operational and strategic risks, establish contingency plans, and pressure-test assumptions, timelines, and budgets to maintain program agility and informed decision-making.
• Serve as the primary liaison between the Core Team and governance committees, presenting program materials with clear, data-driven recommendations and actionable options to support timely approvals.
• Build, influence, and sustain high-performing teams, guiding complex, high-stakes decisions without direct authority.
• Lead cross-functional teams to deliver high-impact program outcomes, challenging assumptions, timelines, and budgets while developing alternative scenarios to mitigate risk and maximize value.
• Own the quality, integrity, and timeliness of team outputs, ensuring company-level decisions are informed by robust, high-caliber data; set pace and priorities to achieve milestones in a highly competitive landscape.
• Serve as the program spokesperson, aligning stakeholders and communicating strategy, progress, and decisions clearly across internal and external audiences.
• Inspire innovation, scientific rigor, and creative problem-solving, fostering a culture of collaboration, continuous improvement, and boundary-less thinking.
• Coach and develop team members to achieve peak performance, cultivating accountability, skill growth, and collective achievement.
• Lead with pragmatism and clarity through ambiguity, charting the path forward and driving complex drug development decisions in fast-paced, dynamic environments.
• Travel up to 20%
• It is imperative that REGENXBIO employees embody our core values by working collaboratively, building strong relationships and using clear communication to meet shared objectives.

What we're looking for

• Bachelor’s degree required; advanced degree (MS, PhD, MBA) in life sciences or healthcare field preferred.
• Proven leader with 8+ years in pharmaceutical industry leadership, with a strong track record driving drug development programs through pivotal stages to commercialization; product launch and early commercialization experience is a strong plus.
• Strong understanding of drug development and commercialization processes, ideally within rare disease or gene therapy
• Deep knowledge of neuromuscular diseases is highly desirable.
• The ability to work well under intense pressure, tight timelines, and in rapidly changing situations
• Evidence of an entrepreneurial spirit and a capacity to find creative solutions to unexpected hurdles
• Interacts effectively across teams with supporting REGENXBIO functions and disciplines using influencing, communication and relationship building skills
• Commitment to anticipate, influence and direct change
• Excellent listening and collaboration skills