{"id":686923,"url":"https://alion.io/job/retro-principal-scientist-analytical-development-quality-control-small-molecule","title":"Analytical Sciences, Small Molecule","company":{"id":685643,"name":"Retro Biosciences","domain":"retro.bio","url":"https://alion.io/company/retro-6","size_band":"51-200","is_staffing_agency":false,"employer_type":"direct","is_intermediary":false,"listed_via":null,"ats_vendor":"Lever","truth_index":null},"role":"Science & Research","role_family":"Science & Research","seniority":"senior","employment_type":"full_time","work_mode":"on_site","remote_scope":null,"remote_scope_basis":null,"remote_working_hours":null,"hiring_geo_confidence":"structured","locations":["Redwood City, United States"],"countries":["US"],"hiring_countries":[],"hiring_countries_total":0,"salary":{"min":175000,"max":210000,"currency":"USD","period":"year","gross":null,"usd_annual":210000},"salary_estimate":null,"experience_years_min":7,"visa_sponsorship":false,"relocation_package":false,"has_equity":false,"technologies":[],"status":"live","first_seen_at":"2026-06-30T15:58:49Z","employer_posted_date":"2026-06-30","last_verified_at":"2026-10-20T23:59:30Z","board_verified":true,"closed_at":null,"days_open":112,"trust":{"level":"stale","repost_count":1,"flags":["stale"],"days_open":111},"description":"Retro develops therapies for diseases driven by the biology of aging. We focus on cellular reprogramming and autophagy to broadly improve tissue function by targeting mechanisms of aging with the ultimate aim of adding 10 years to healthy human lifespan.\nWe’re building a mission-driven team of accomplished and kind individuals who embrace our startup culture of rapid iteration, transparency, and versatility.\nAbout the Role:\nWe are hiring a new member of the Autophagy team to be the primary scientist supporting Retro’s clinical stage autophagy program through analytical development and quality control as it advances from Phase I toward Phase II development. This role will report to the leader of the autophagy team and partner closely with the CMC lead and Quality team to develop and execute the analytical strategy for RTR242 as well as next-generation compounds.\nAbout You:\nYou are a rigorous, curious, small-molecule analytical development professional who seeks to understand the underlying science and regulatory framework, not just execute against it. You stay current by engaging directly with guidelines, literature, and data, and pair scientific depth with practical judgment. You are confident yet humble in evolving areas and enjoy sharing knowledge and exchanging ideas openly. You are comfortable in a lean environment, balancing hands-on work with oversight of external partners. You communicate clearly across internal and external partners, and are excited to thoughtfully incorporate new tools, including AI, into analytical and CMC workflows.\nin this role you will:\nDrive and own analytical control strategy development for Retro’s small molecule autophagy program - test methods, specifications, stability, and impurity control for drug substance and drug product - as it advances from Phase I toward Phase II.\n\nDevelop analytical methods internally, with hands-on UPLC and LC-MS work, including characterization of process impurities and degradation products.\n\nTransfer methods to external partners.\n\nOversee outsourced analytical and QC activities, including method development, validation, release testing, stability monitoring, OOS/OOT investigations, and data package review.\n\nSupport identity testing for critical raw materials, including method selection, vendor coordination, data review, and targeted in-house analytical work.\n\nSupport formulation development by using analytical data to evaluate solubility, dissolution, stability, and provide analytical support to discovery and preclinical programs.\n\nAuthor and review analytical sections of Module 3 submissions, covering methods, specifications, validation, stability and control strategy.\nPartner with the CMC lead and quality team, and manage external CDMOs and CROs.\n\nSupport bioanalytical development work for future generations of the compound.\n\nYou might thrive in this role if you:\nHave a MS or PhD in analytical chemistry, medicinal chemistry, pharmaceutical sciences, or a related field, with 7+ years relevant industry experience in small-molecule analytical development, including experience in a regulated GxP environment.\n\nUnderstand phase-appropriate analytical control strategy, including specifications, stability strategy, impurity control, reference standards, method validation, and regulatory documentation.\n\nHave experience developing, validating, transferring, and overseeing analytical methods for drug substance and drug product release, stability, dissolution, and impurity testing.\n\nHave experience working with CDMOs, CROs, or external laboratories to manage analytical development, validation, release testing, stability testing, investigations, and data review.\n\nBring hands-on expertise with UPLC/HPLC and LC-MS method development, troubleshooting, and data interpretation for small molecule assay, purity, impurities, degradation products, and related substances.\n\nCan operate independently in a lean environment, prioritize across internal hands-on work and external partner oversight, and communicate analytical recommendations clearly to cross-functional partners.\n\nIt’s a bonus if you:\nHave run LC-MS/MS for drugs and metabolites in complex biological matrices.\n\nHave experience contributing to or reviewing analytical sections of CTD Module 3 submissions; direct authoring experience is preferred.\n\nHave worked on extractables and leachables, container closure, or device compatibility studies.\n\nHave supported discovery or preclinical programs with analytical data to accelerate progression decisions.","description_format":"text","description_chars":4530,"description_truncated":false,"requirements":{"experience_years_min":7,"management_years_min":null,"team_size_min":null,"manages_managers":false,"education":{"level":"phd","optional":false},"security_clearance":false,"languages":[]},"benefits":[],"hiring_locations":[],"hiring_excludes":[],"relocation_offered":false,"industries":["Drug Discovery"],"lifecycle":[{"event":"open","at":"2026-09-11T00:27:05Z"},{"event":"close","at":"2026-09-14T00:57:49Z"},{"event":"reopen","at":"2026-09-15T15:44:15Z"}],"visa":[{"country":"US","licensed_sponsor":true,"evidence":"H-1B filings in 12 months: 3","filings_12m":3,"filings_prev_12m":2,"green_card_filings_12m":0,"median_offered_wage_usd":187500,"route":null,"cap_exempt":false,"checked_at":"2026-10-15T11:24:14+00:00","sources":["US Department of Labor: LCA disclosure data (H-1B, H-1B1, E-3)"],"filings_for_role_12m":0}],"liveness":{"score":11,"band":"cold","label":"Long shot","p_open":1,"p_active":0.391,"p_room":0.28,"age_days":111,"expected_fill_days":36,"reasons":["conf:2","win:tail","crowd:"],"computed_at":"2026-10-20T05:45:00Z"},"pay":{"stated_usd_annual":210000,"is_top_pay":true},"html_url":"https://alion.io/job/retro-principal-scientist-analytical-development-quality-control-small-molecule","json_url":"https://alion.io/job/retro-principal-scientist-analytical-development-quality-control-small-molecule.json","meta":{"generated_at":"2026-10-21T02:25:17Z","cache_seconds":300,"methodology":"https://alion.io/methodology","terms":"https://alion.io/terms","contact":"https://alion.io/contact","api":"https://alion.io/developers","about":"Alion is a live layer of people, companies and AI agents: who they are, whether they are real and active right now, what they do and how to work with them, readable by people and by agents and paid per call.","catalog":"https://alion.io/catalog.json","usage":{"tier":"crawler_verified","counted_by":"address","units_charged":1,"used_today":3601,"day_limit":null,"remaining_today":null,"minute_limit":300,"resets_at":"2026-10-22T00:00:00Z"}},"offers":[{"id":"company.slices","title":"One company in depth, by slice","status":"live","price":{"credits":0.02,"usd":0.002,"plus_per_slice":{"credits":0.05,"usd":0.005}},"unit":"per company, plus each slice with data","note":"the employer in depth","call":{"mcp_tool":"get_company","arguments":{"id":685643},"rest":"https://alion.io/mcp/rest/get_company?id=685643"},"human":"https://alion.io/catalog?offer=company.slices&for=job%2Fretro-principal-scientist-analytical-development-quality-control-small-molecule"},{"id":"market.stats","title":"A market slice: pay, demand and time to fill","status":"live","price":{"credits":1,"usd":0.1},"unit":"per slice","note":"pay, demand and time to fill for this role and place","call":{"mcp_tool":"market_stats"},"human":"https://alion.io/catalog?offer=market.stats&for=job%2Fretro-principal-scientist-analytical-development-quality-control-small-molecule"},{"id":"job.search","title":"Open jobs by role, technology, place, pay and visa","status":"live","price":{"credits":0.02,"usd":0.002},"unit":"per posting in a list","note":"similar open postings","call":{"mcp_tool":"search_jobs"},"human":"https://alion.io/catalog?offer=job.search&for=job%2Fretro-principal-scientist-analytical-development-quality-control-small-molecule"},{"id":"company.verify","title":"Is this company real and active right now","status":"pilot","price":null,"unit":"per company","request":{"url":"https://alion.io/catalog/request","method":"POST","body":"{\"offer\": \"company.verify\", \"for\": \"job/retro-principal-scientist-analytical-development-quality-control-small-molecule\", \"note\": \"what you need it for\"}"},"human":"https://alion.io/catalog?offer=company.verify&for=job%2Fretro-principal-scientist-analytical-development-quality-control-small-molecule"}]}