{"id":335496,"url":"https://alion.io/job/roche-principal-bioinformatics-scientist-i","title":"Principal Bioinformatics Scientist I","company":{"id":13531,"name":"Roche","domain":"roche.com","url":"https://alion.io/company/roche","size_band":"5000+","is_staffing_agency":false,"employer_type":"direct","is_intermediary":false,"listed_via":null,"ats_vendor":"Workday","truth_index":{"grade":"A","score":85,"open_postings":191,"ghost_share":0.037,"stale_share":0.654,"repost_share":0.105,"time_to_fill_p50_days":20,"computed_at":"2026-11-02T06:13:15Z"}},"role":"Science & Research","role_family":"Science & Research","seniority":"lead","employment_type":"full_time","work_mode":"on_site","remote_scope":null,"remote_scope_basis":null,"remote_working_hours":null,"hiring_geo_confidence":"structured","locations":["Mississauga, Canada"],"countries":["CA"],"hiring_countries":[],"hiring_countries_total":0,"salary":null,"salary_estimate":{"min_usd":48000,"max_usd":116000,"period":"year","method":"role_seniority_country_remote_cell","sample_n":17},"experience_years_min":7,"visa_sponsorship":false,"relocation_package":false,"has_equity":false,"technologies":[{"name":"Bash","optional":false},{"name":"C++","optional":false},{"name":"CI/CD","optional":false},{"name":"Docker","optional":false},{"name":"Git","optional":false},{"name":"Linux","optional":false},{"name":"Next-Generation Sequencing","optional":false},{"name":"Python","optional":false}],"status":"live","first_seen_at":"2026-09-02T00:00:00Z","employer_posted_date":"2026-10-08","last_verified_at":"2026-11-02T07:39:48Z","board_verified":true,"closed_at":null,"days_open":61,"trust":{"level":"ok","repost_count":1,"flags":[],"days_open":61},"description":"At Roche you can show up as yourself, embraced for the unique qualities you bring. Our culture encourages personal expression, open dialogue, and genuine connections, where you are valued, accepted and respected for who you are, allowing you to thrive both personally and professionally. This is how we aim to prevent, stop and cure diseases and ensure everyone has access to healthcare today and for generations to come. Join Roche, where every voice matters.\nThe Position\nPrincipal Bioinformatics Scientist I\nThis role is a vital part of our Bioinformatics team, which is committed to advancing precision medicine by building cutting-edge computational tools for clinical diagnostics. As a member of this team, you will sit at the dynamic intersection of computational biology, assay development, and software engineering to translate complex genomic data into actionable health insights.\nYou will have the opportunity to collaborate closely with cross-functional partners across Wet-Lab Assay Development, Software Engineering, CLIA Operations, and Quality to design, validate, and operationalize next-generation diagnostic tests.\nThe Opportunity\nAs a Bioinformatics Scientist, you will lead the design, optimization, and clinical validation of innovative NGS data processing pipelines and algorithms. You will serve as the technical bridge between wet-lab innovation and production-grade software engineering, leveraging advanced statistical modeling and modern AI coding tools to deliver high-accuracy molecular diagnostics for patient care.\nPipeline & Algorithm Development: Design, benchmark, and optimize scalable, reproducible NGS bioinformatics pipelines using Nextflow, Docker/Singularity, and cloud environments.\n Analytical Validation: Partner with Assay Development and CLIA lab teams to establish statistical analysis plans and validate novel diagnostic assays (ensuring high sensitivity, specificity, and precision).\nAI-Accelerated Engineering: Routinely integrate AI coding tools and automated workflows to accelerate algorithm development, refactoring, and data analysis.\nProduction Translation: Draft clear functional and technical specifications to guide software engineering teams in transitioning research prototypes into robust clinical software.\nQuality & Regulatory Compliance: Implement sample- and run-level statistical QC metrics while maintaining thorough QMS-compliant documentation for CAP/CLIA audits.\nBest Practices: Enforce high-standard software engineering practices, including Git version control, continuous integration, unit testing, and modular architecture.\nWho You Are\n Education & Experience: Master’s degree with 7+ years of related experience; OR Ph.D. with 4+ years of related experience (work experience can be prior or post-grad; relevant post-grad academic lab training will be considered).\n Matrixed Collaboration & Stakeholder Management: Proven ability to partner seamlessly across multidisciplinary teams-including wet-lab scientists, software engineers, lab directors, and Quality assurance-to align technical specs with clinical goals.\nTechnical Mastery\nDeep understanding of high-throughput sequencing data analysis across various modalities (targeted panels, WGS/WES, transcriptomics, or liquid biopsy/ctDNA).\nProficient in Python/R/C++ and Linux/Bash alongside hands-on experience using workflow managers (Nextflow) and containerized software deployments.\nModern Workflow Adaptability: Proven ability to leverage AI development tools to maximize productivity, alongside excellent communication skills suited for navigating complex, cross-functional organizational environments.\nRelocation benefits are not available for this position.\nThe expected salary range for this position based on the primary location of Mississauga is 115,328.00 and 151,368.00 of hiring range. Actual pay will be determined based on experience, qualifications, and other job-related factors as determined by the company.\nWe use artificial intelligence to screen, assess or select applicants for this role.\nThis posting is for an existing vacancy at Hoffmann-La Roche Ltd.\nWho we are\nA healthier future drives us to innovate. Together, more than 100’000 employees across the globe are dedicated to advance science, ensuring everyone has access to healthcare today and for generations to come. Our efforts result in more than 26 million people treated with our medicines and over 30 billion tests conducted using our Diagnostics products. We empower each other to explore new possibilities, foster creativity, and keep our ambitions high, so we can deliver life-changing healthcare solutions that make a global impact.\nLet’s build a healthier future, together.\nRoche is an Equal Opportunity Employer.","description_format":"text","description_chars":4732,"description_truncated":false,"requirements":{"experience_years_min":7,"management_years_min":null,"team_size_min":null,"manages_managers":false,"education":{"level":"master","optional":false},"security_clearance":false,"languages":[]},"benefits":[],"hiring_locations":[],"hiring_excludes":[],"relocation_offered":true,"industries":["Bioinformatics","Artificial Intelligence","Biotechnology","Health Care"],"lifecycle":[{"event":"open","at":"2026-09-05T17:41:15Z"},{"event":"close","at":"2026-09-11T04:19:58Z"},{"event":"reopen","at":"2026-10-08T21:48:20Z"}],"visa":[],"liveness":{"score":13,"band":"cold","label":"Long shot","p_open":1,"p_active":0.448,"p_room":0.28,"age_days":61,"expected_fill_days":20,"reasons":["conf:9","stale_co","velocity","win:tail","crowd:brand"],"computed_at":"2026-11-02T06:13:15Z"},"pay":null,"html_url":"https://alion.io/job/roche-principal-bioinformatics-scientist-i","json_url":"https://alion.io/job/roche-principal-bioinformatics-scientist-i.json","meta":{"generated_at":"2026-11-02T10:18:56Z","cache_seconds":300,"methodology":"https://alion.io/methodology","terms":"https://alion.io/terms","contact":"https://alion.io/contact","api":"https://alion.io/developers","about":"Alion is a live layer of people, companies and AI agents: who they are, whether they are real and active right now, what they do and how to work with them, readable by people and by agents and paid per call.","catalog":"https://alion.io/catalog.json","usage":{"tier":"crawler_verified","counted_by":"address","units_charged":1,"used_today":14389,"day_limit":null,"remaining_today":null,"minute_limit":300,"resets_at":"2026-11-03T00:00:00Z"}},"offers":[{"id":"company.slices","title":"One company in depth, by slice","status":"live","price":{"credits":0.02,"usd":0.002,"plus_per_slice":{"credits":0.05,"usd":0.005}},"unit":"per company, plus each slice with data","note":"the employer in depth","call":{"mcp_tool":"get_company","arguments":{"id":13531},"rest":"https://alion.io/mcp/rest/get_company?id=13531"},"human":"https://alion.io/catalog?offer=company.slices&for=job%2Froche-principal-bioinformatics-scientist-i"},{"id":"market.stats","title":"A market slice: pay, demand and time to fill","status":"live","price":{"credits":1,"usd":0.1},"unit":"per slice","note":"pay, demand and time to fill for this role and place","call":{"mcp_tool":"market_stats"},"human":"https://alion.io/catalog?offer=market.stats&for=job%2Froche-principal-bioinformatics-scientist-i"},{"id":"job.search","title":"Open jobs by role, technology, place, pay and visa","status":"live","price":{"credits":0.02,"usd":0.002},"unit":"per posting in a list","note":"similar open postings","call":{"mcp_tool":"search_jobs"},"human":"https://alion.io/catalog?offer=job.search&for=job%2Froche-principal-bioinformatics-scientist-i"},{"id":"company.verify","title":"Is this company real and active right now","status":"pilot","price":null,"unit":"per company","request":{"url":"https://alion.io/catalog/request","method":"POST","body":"{\"offer\": \"company.verify\", \"for\": \"job/roche-principal-bioinformatics-scientist-i\", \"note\": \"what you need it for\"}"},"human":"https://alion.io/catalog?offer=company.verify&for=job%2Froche-principal-bioinformatics-scientist-i"}],"agent":{"mcp":"https://alion.io/mcp/jobs","mcp_open":"https://alion.io/mcp/open","next":[{"tool":"get_job","arguments":{"id":335496}},{"tool":"search_jobs","arguments":{"company":"roche.com","detail":"compact"}},{"tool":"match_people","arguments":{"job_id":335496},"note":"people open to offers who fit this vacancy"}],"note":"The same data through MCP tools: https://alion.io/mcp/open needs no sign-in (compact searches, postings, people); https://alion.io/mcp with an Alion account has everything. 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