{"id":1323077,"url":"https://alion.io/job/sail-biomedicines-scientist-platform-rna-sciences","title":"Scientist, Platform RNA Sciences","company":{"id":3780304,"name":"Sail Biomedicines","domain":"sail.bio","url":"https://alion.io/company/sail-6","size_band":null,"is_staffing_agency":false,"employer_type":"direct","is_intermediary":false,"listed_via":null,"ats_vendor":"Greenhouse","truth_index":null},"role":"Science & Research","role_family":"Science & Research","seniority":"senior","employment_type":null,"work_mode":"on_site","remote_scope":null,"remote_scope_basis":null,"remote_working_hours":null,"hiring_geo_confidence":"structured","locations":["Cambridge, United States"],"countries":["US"],"hiring_countries":[],"hiring_countries_total":0,"salary":{"min":98000,"max":125000,"currency":"USD","period":"year","gross":null,"usd_annual":125000},"salary_estimate":null,"experience_years_min":6,"visa_sponsorship":false,"relocation_package":false,"has_equity":false,"technologies":[{"name":"Benchling","optional":false},{"name":"Chromatography","optional":false},{"name":"Jira","optional":false},{"name":"JMP","optional":false},{"name":"qPCR","optional":false},{"name":"Smartsheet","optional":false},{"name":"Next-Generation Sequencing","optional":true}],"status":"live","first_seen_at":"2026-08-25T00:31:54Z","employer_posted_date":"2026-08-25","last_verified_at":"2026-11-06T10:35:55Z","board_verified":true,"closed_at":null,"days_open":73,"trust":{"level":"ok","repost_count":null,"flags":[],"days_open":73},"description":"About Sail \nSail Biomedicines is pioneering the integrative design and deployment of fully programmable medicines to transform patient care. Sail’s platform combines first-in-class programmable circular RNA technology (Endless RNA™ or eRNA), and an industry-leading platform of programmable nanoparticles, utilizing natural components, to unlock comprehensive programming of medicines for the first time. By leveraging cutting-edge eRNA and nanoparticle deployment technology, Sail is also making unparalleled use of AI techniques to identify and design fully programmable medicines that are potent, targeted, versatile, and tunable. Sail was founded by Flagship Pioneering. \nThe Role\nThe Scientist, Platform RNA Sciences, will work on key projects to advance Sail’s first-in-class programmable circular RNA technology (Endless RNA™ or eRNA). This role works cross-functionally to perform hypothesis-driven experiments and high-throughput screens to improve our eRNA designs, with the goal to maximize circularization, and enhance RNA stability and translation. The successful candidate is self-motivated, curious and creative, thinks outside of the box and has a can-do mindset. The team looks forward to helping you strive in this exciting and fast-paced environment to make a real-world impact on patients’ lives.\nResponsibilities \nConceive and conduct pooled and array screens to improve our eRNA designs, enabling higher product purity and function\nDesign hypothesis-driven experiments based on state-of-the-art RNA biology to refine our eRNA designs\nEvaluate and develop alternative circularization strategies\nDetermine circularization efficiency and impurity levels by running analytic assays\nDesign properly controlled experiments, generate high-quality data, and run rigorous statistical analysis\nMaintain detailed documentation in electronic lab notebooks\nAuthor standard operating procedures (SOPs), study summaries, and technical reports\nPresent findings clearly in oral or written formats to internal and external stakeholders to enable alignment and decision-making\nQualifications\nPh.D. in Molecular Biology, Biochemistry, or a related field, or M.S. with 6+ years of focused, full-time research experience in RNA technologies\nStrong background in RNA biology with demonstrated skillset in relevant molecular and biochemical techniques, such as in vitro transcription (IVT), RNA purification, oligo-dT purification, column chromatography, capillary gel electrophoresis, RT-qPCR, RNA-seq, Nanopore sequencing\nExperience using data analysis and information management tools, such as Excel, Graphic Prism, R, JMP, SnapGene, Benchling, Smartsheet, Jira\nExcellent problem-solving skills with the ability to independently design and carry out experiments\nAbility to manage multiple tasks at once while knowing how to prioritize\nStrong collaborative spirit and excellent organizational and communication skills\nExcellent record keeping\nPreferred Qualifications\nExperience in Next Generation Sequencing (NGS) library preparation\nWorking knowledge in engineering ribozyme, aptamer or other complex RNA structures\nSalary Range: $98,000 - $125,000\nSail Biomedicines is an Equal Opportunity Employer. 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