{"id":3787557,"url":"https://alion.io/job/sanofi-scientist-downstream-process-scale-up","title":"Scientist, Downstream Process Scale-Up","company":{"id":146,"name":"Sanofi","domain":"sanofi.com","url":"https://alion.io/company/sanofi","size_band":"1001-5000","is_staffing_agency":false,"employer_type":"direct","is_intermediary":false,"listed_via":null,"ats_vendor":"Workday","truth_index":{"grade":"A","score":95,"open_postings":103,"ghost_share":0.01,"stale_share":0.311,"repost_share":0.078,"time_to_fill_p50_days":21,"computed_at":"2026-11-05T05:54:30Z"}},"role":"Science & Research","role_family":"Science & Research","seniority":"middle","employment_type":"full_time","work_mode":"on_site","remote_scope":null,"remote_scope_basis":null,"remote_working_hours":null,"hiring_geo_confidence":"structured","locations":["Waltham, United States"],"countries":["US"],"hiring_countries":[],"hiring_countries_total":0,"salary":null,"salary_estimate":null,"experience_years_min":4,"visa_sponsorship":false,"relocation_package":false,"has_equity":false,"technologies":[{"name":"Chromatography","optional":true},{"name":"GLP","optional":true}],"status":"live","first_seen_at":"2026-11-04T00:00:00Z","employer_posted_date":"2026-11-04","last_verified_at":"2026-11-05T16:30:51Z","board_verified":true,"closed_at":null,"days_open":1,"trust":{"level":"ok","repost_count":null,"flags":[],"days_open":1},"description":"Job Title: Scientist\nLocation: Waltham, MA\nAbout the Job:\nThe Genomic Medicine Unit (GMU) Chemistry, Manufacturing and Control (CMC) group at Sanofi is dedicated to the establishment of best-in-class manufacturing platforms to support development of life-changing advanced cell and gene therapy products, including recombinant AAV vectors and non-viral vectors. This organization encompasses vector and cell line engineering, upstream and downstream process development, analytics, and clinical manufacturing support.\nThe GMU purification process development group is responsible for the development of AAV viral vector processes and for supporting viral vector purification for next-generation production platforms to enable high-dose gene therapy programs. The Scientist role requires leadership both inside and outside the laboratory and will rely on industry expertise and the exploration of novel technologies in order to build robust and efficient purification processes consistent with patient safety standards.\nWe are looking for a candidate with hands-on experience executing downstream purification at pilot and large scale, with a strong background in scale-up and some exposure to technology transfer. Experience across biologics modalities is valued, and experience with AAV or other viral vectors is a plus.\nJoin the engine of Sanofi’s mission - where deep immunoscience meets bold, AI-powered research. In R&D, you’ll drive breakthroughs that could turn the impossible into possible for millions.\nAbout Sanofi:\nWe’re an R&D-driven, AI-powered biopharma company committed to improving people’s lives and delivering compelling growth. Our deep understanding of the immune system - and innovative pipeline - enables us to invent medicines and vaccines that treat and protect millions of people around the world. Together, we chase the miracles of science to improve people’s lives.\nMain Responsibilities:\nLead the execution and scale-up of downstream purification manufacturing, from 50-L pilot through 2000-L scale, partnering with CMC project teams on logistical planning for pre-clinical manufacturing campaigns\nLead the authoring, review, and revision of SOPs, batch records, and batch reports for pilot and large-scale downstream operations\nPerform data analyses supporting pilot and large-scale DSP manufacturing, and contribute to technical reports and internal/external presentations\nLead troubleshooting of manufacturing issues and communicate findings to appropriate working groups\nMaintain critical process equipment and consumables to minimize downtime, and lead or support evaluation of new process technologies to improve yield, cost, and cycle times\nSupport digital transformation and continuous improvement initiatives within GMU CMC (e.g., electronic batch records, process data capture, workflow enhancements)\nDevelop and maintain advanced knowledge of column chromatography, filtration, and related purification technologies; mentor junior staff and foster a collaborative team culture\nAbout You:\nEducation:\nMaster’s degree in chemical or biochemical engineering or related disciplines with a minimum of 2 years of relevant experience or a bachelor’s degree with a minimum of 4 years of relevant experience\nExperience & Technical Skills:\nSignificant experience of working with pilot- and large-scale DSP manufacturing unit operations\nSignificant experience, knowledge, and understanding of purification technologies and operations.Required: Hands-on experience with Chromatography and Tangential Flow Filtration (TFF)\nPreferred: Experience with Depth Filtration and/or Viral Filtration/Inactivation.\n\nExperience with process technology transfers and performing gap analyses and risk assessments\nExpertise in drafting batch records and SOPs (required); experience authoring technical reports (preferred).\nPreferred Qualifications:\nExperience in AAV purification development\nExperience in CMC and drug development\nExperience with digital solutions to enable efficient manufacturing operations (e.g. electronic batch records, electronic notebooks, etc.). Knowledge of product comparability, target product profile and quality risk assessment activities\nKnowledge of basic analytical tools such as UV spectrophotometry and DLS particle sizing\nAbility to work in Biosafety Level 2, follow safe lab procedures and maintain good laboratory practices (GLPs)\nSoft Skills:\nAbility to work under minimal supervision and function within a collaborative, team-oriented environment\nExcellent organization and communication skills\nAbility to communicate and represent group in diverse, multi-functional meetings\nWhy choose us?\nBring the miracles of science to life alongside a supportive, future focused team.\nDiscover endless opportunities to grow your talent and drive your career, whether it’s through a promotion or lateral move, at home or internationally.\nEnjoy a thoughtful, well-crafted rewards package that recognizes your contribution and amplifies your impact.\nTake good care of yourself and your family, with a wide range of health and wellbeing benefits including high-quality healthcare, prevention and wellness programs and at least 14 weeks’ gender-neutral parental leave.\nBe part of a pioneering biopharma company that engages patients early in drug development and uses their insights to design studies that reflect real-world needs.\nWork at the forefront of drug discovery, harnessing cutting-edge AI, data, and digital platforms to push the boundaries of science.\nHelp improve the lives of millions of people globally by making drug development quicker and more effective.\nSanofi US Services and its U.S. affiliates are Equal Opportunity employers committed to a culturally inclusive workforce. All qualified applicants will receive consideration for employment without regard to race; color; creed; religion; national origin; age; ancestry; nationality; marital, domestic partnership or civil union status; sex, gender, gender identity or expression; affectional or sexual orientation; disability; veteran or military status or liability for military status; domestic violence victim status; atypical cellular or blood trait; genetic information (including the refusal to submit to genetic testing) or any other characteristic protected by law.\n#GD-SA\nPursue progress, discover extraordinary\nBetter is out there. Better medications, better outcomes, better science. But progress doesn’t happen without people - people from different backgrounds, in different locations, doing different roles, all united by one thing: a desire to make miracles happen. So, let’s be those people.\nSanofi US endeavours to make our career center accessible to any and all users. If you are experiencing difficulty and need assistance applying online, please call 1-866-SANOFI2 (1-866-726-6342) or click here\nUS and Puerto Rico Residents Only\nSanofi Inc. and its U.S. affiliates are Equal Opportunity employers committed to a culturally inclusive workforce. All qualified applicants will receive consideration for employment without regard to race; color; creed; religion; national origin; age; ancestry; nationality; marital, domestic partnership or civil union status; sex, gender, gender identity or expression; affectional or sexual orientation; disability; veteran or military status or liability for military status; domestic violence victim status; atypical cellular or blood trait; genetic information (including the refusal to submit to genetic testing) or any other characteristic protected by law.\nNorth America Applicants Only\nThe salary range for this position is:\n$85.500,00 - $123.500,00All compensation will be determined commensurate with demonstrated experience. Employees may be eligible to participate in Company employee benefit programs, and additional benefits information can be found here.","description_format":"text","description_chars":7830,"description_truncated":false,"requirements":{"experience_years_min":4,"management_years_min":null,"team_size_min":null,"manages_managers":false,"education":{"level":"bachelor","optional":false},"security_clearance":false,"languages":[]},"benefits":["Parental leave","Wellness"],"hiring_locations":[{"name":"United States","iso":"US","kind":"country"},{"name":"Puerto Rico","iso":"PR","kind":"country"}],"hiring_excludes":[],"relocation_offered":false,"industries":["Prescription Drugs","Vaccines","Rare Disease Therapeutics","Immunology & Inflammation Therapeutics"],"lifecycle":[{"event":"open","at":"2026-11-05T04:14:11Z"}],"visa":[{"country":"US","licensed_sponsor":true,"evidence":"H-1B filings in 12 months: 62","filings_12m":62,"filings_prev_12m":36,"green_card_filings_12m":0,"median_offered_wage_usd":127500,"route":null,"cap_exempt":false,"checked_at":"2026-10-29T16:27:21+00:00","sources":["US Department of Labor: LCA disclosure data (H-1B, H-1B1, E-3)"],"filings_for_role_12m":0}],"liveness":{"score":90,"band":"hot","label":"Hiring now","p_open":1,"p_active":0.903,"p_room":1,"age_days":1,"expected_fill_days":21,"reasons":["conf:1","velocity","win:early","comp:brand"],"computed_at":"2026-11-05T05:54:30Z"},"pay":null,"html_url":"https://alion.io/job/sanofi-scientist-downstream-process-scale-up","json_url":"https://alion.io/job/sanofi-scientist-downstream-process-scale-up.json","meta":{"generated_at":"2026-11-05T20:56:47Z","cache_seconds":300,"methodology":"https://alion.io/methodology","terms":"https://alion.io/terms","contact":"https://alion.io/contact","api":"https://alion.io/developers","about":"Alion is a live layer of people, companies and AI agents: who they are, whether they are real and active right now, what they do and how to work with them, readable by people and by agents and paid per call.","catalog":"https://alion.io/catalog.json","usage":{"tier":"crawler_verified","counted_by":"address","units_charged":1,"used_today":590,"day_limit":null,"remaining_today":null,"minute_limit":300,"resets_at":"2026-11-06T00:00:00Z"}},"offers":[{"id":"company.slices","title":"One company in depth, by slice","status":"live","price":{"credits":0.02,"usd":0.002,"plus_per_slice":{"credits":0.05,"usd":0.005}},"unit":"per company, plus each slice with data","note":"the employer in depth","call":{"mcp_tool":"get_company","arguments":{"id":146},"rest":"https://alion.io/mcp/rest/get_company?id=146"},"human":"https://alion.io/catalog?offer=company.slices&for=job%2Fsanofi-scientist-downstream-process-scale-up"},{"id":"market.stats","title":"A market slice: pay, demand and time to fill","status":"live","price":{"credits":1,"usd":0.1},"unit":"per slice","note":"pay, demand and time to fill for this role and place","call":{"mcp_tool":"market_stats"},"human":"https://alion.io/catalog?offer=market.stats&for=job%2Fsanofi-scientist-downstream-process-scale-up"},{"id":"job.search","title":"Open jobs by role, technology, place, pay and visa","status":"live","price":{"credits":0.02,"usd":0.002},"unit":"per posting in a list","note":"similar open postings","call":{"mcp_tool":"search_jobs"},"human":"https://alion.io/catalog?offer=job.search&for=job%2Fsanofi-scientist-downstream-process-scale-up"},{"id":"company.verify","title":"Is this company real and active right now","status":"pilot","price":null,"unit":"per company","request":{"url":"https://alion.io/catalog/request","method":"POST","body":"{\"offer\": \"company.verify\", \"for\": \"job/sanofi-scientist-downstream-process-scale-up\", \"note\": \"what you need it for\"}"},"human":"https://alion.io/catalog?offer=company.verify&for=job%2Fsanofi-scientist-downstream-process-scale-up"}],"agent":{"mcp":"https://alion.io/mcp/jobs","mcp_open":"https://alion.io/mcp/open","next":[{"tool":"get_job","arguments":{"id":3787557}},{"tool":"search_jobs","arguments":{"company":"sanofi.com","detail":"compact"}},{"tool":"match_people","arguments":{"job_id":3787557},"note":"people open to offers who fit this vacancy"}],"note":"The same data through MCP tools: https://alion.io/mcp/open needs no sign-in (compact searches, postings, people); https://alion.io/mcp with an Alion account has everything. Docs: https://alion.io/developers"}}