{"id":1927135,"url":"https://alion.io/job/scholar-rock-sr-scientist-antibody-engineering","title":"Sr. Scientist, Antibody Engineering","company":{"id":686370,"name":"Scholar Rock","domain":"scholarrock.com","url":"https://alion.io/company/scholarrock","size_band":"501-1000","is_staffing_agency":false,"employer_type":"direct","is_intermediary":false,"listed_via":null,"ats_vendor":"Lever","truth_index":{"grade":"B","score":80,"open_postings":5,"ghost_share":0,"stale_share":0.8,"repost_share":0,"time_to_fill_p50_days":51,"computed_at":"2026-10-27T05:46:45Z"}},"role":"Science & Research","role_family":"Science & Research","seniority":"senior","employment_type":"full_time","work_mode":"on_site","remote_scope":null,"remote_scope_basis":null,"remote_working_hours":null,"hiring_geo_confidence":"structured","locations":["Cambridge, United States"],"countries":["US"],"hiring_countries":[],"hiring_countries_total":0,"salary":{"min":125000,"max":155000,"currency":"USD","period":"year","gross":null,"usd_annual":155000},"salary_estimate":null,"experience_years_min":null,"visa_sponsorship":false,"relocation_package":false,"has_equity":false,"technologies":[{"name":"Antibody Engineering","optional":false},{"name":"Chromatography","optional":true},{"name":"ELISA","optional":true},{"name":"Flow Cytometry","optional":true}],"status":"live","first_seen_at":"2026-10-05T18:45:46Z","employer_posted_date":"2026-10-05","last_verified_at":"2026-10-27T19:46:57Z","board_verified":true,"closed_at":null,"days_open":22,"trust":{"level":"ok","repost_count":null,"flags":[],"days_open":22},"description":"At Scholar Rock, we strive to develop best-in-class antibody-based therapeutics across multiple disease areas by leveraging our Antibody Engineering and Structural Biology expertise. Scholar Rock is seeking highly motivated, energetic and collaborative Senior Scientist to join the Antibody Discovery and Engineering group. The successful candidate will design and execute antibody discovery and optimization campaigns using phage display and yeast display technology, contribute to the development and application of display-based screening strategies, and advance high-quality leads through biochemical and biophysical characterization. Hands-on experience with phage display is required; experience with yeast display is preferred. Experience in recombinant protein purification and characterization are highly desirable.\nPosition Responsibilities\nDesign, execute, and troubleshoot antibody discovery campaigns using phage display, including library screening, selection strategy development, clone recovery, and sequence analysis.\nOptimizing antibody leads with display-based technologies, including affinity maturation, specificity engineering, and developability-focused screening.\nExpress and purify recombinant antibodies, antibody fragments, antigens, and related proteins using appropriate chromatographic methods.\nCharacterize binding, specificity, affinity, stability, purity, and other biochemical or biophysical properties of antibody candidates.\nAnalyze and interpret experimental data, maintain clear records, and communicate results and recommendations to project teams.\nCollaborate cross-functionally with protein sciences, structural biology, assay biology, and therapeutic-area teams to advance discovery programs.\nEvaluate and implement new technologies, workflows, and automation opportunities that strengthen antibody discovery and optimization capabilities.\nProvide scientific leadership for project workstreams and mentor junior colleagues as appropriate.\nCandidate Requirements\nPh.D. in biochemistry, molecular biology, protein engineering, biophysics, or a related life-science field with relevant industry or postdoctoral experience; or an M.S./B.S. with commensurate relevant experience. Level will be determined by qualifications and experience.\nHands on experience with antibody discovery and optimization using phage display is required, yeast display experience is highly preferred. \nWorking knowledge of antibody formats, library design or screening principles, molecular biology, and sequence-based clone assessment.\nExperience with protein purification techniques such as affinity, ion-exchange, and size-exclusion chromatography.\nAbility to characterize proteins and antibodies using biochemical and biophysical methods such as SPR, BLI, ELISA, and flow cytometry.\nStrong experimental design, problem-solving, documentation, communication, and teamwork skills.\nExperience in applying structural insights to antibody design and optimization is preferred.","description_format":"text","description_chars":2990,"description_truncated":false,"requirements":{"experience_years_min":null,"management_years_min":null,"team_size_min":null,"manages_managers":false,"education":{"level":"phd","optional":false},"security_clearance":false,"languages":[]},"benefits":[],"hiring_locations":[],"hiring_excludes":[],"relocation_offered":false,"industries":["Biologics & Biosimilars","Rare Disease Therapeutics"],"lifecycle":[{"event":"open","at":"2026-10-05T20:23:48Z"}],"visa":[],"liveness":{"score":80,"band":"hot","label":"Hiring now","p_open":1,"p_active":0.894,"p_room":0.9,"age_days":21,"expected_fill_days":51,"reasons":["conf:3","velocity","win:mid"],"computed_at":"2026-10-27T05:46:45Z"},"pay":{"stated_usd_annual":155000,"is_top_pay":true},"html_url":"https://alion.io/job/scholar-rock-sr-scientist-antibody-engineering","json_url":"https://alion.io/job/scholar-rock-sr-scientist-antibody-engineering.json","meta":{"generated_at":"2026-10-27T21:25:46Z","cache_seconds":300,"methodology":"https://alion.io/methodology","terms":"https://alion.io/terms","contact":"https://alion.io/contact","api":"https://alion.io/developers","about":"Alion is a live layer of people, companies and AI agents: who they are, whether they are real and active right now, what they do and how to work with them, readable by people and by agents and paid per call.","catalog":"https://alion.io/catalog.json","usage":{"tier":"crawler_verified","counted_by":"address","units_charged":1,"used_today":12812,"day_limit":null,"remaining_today":null,"minute_limit":300,"resets_at":"2026-10-28T00:00:00Z"}},"offers":[{"id":"company.slices","title":"One company in depth, by slice","status":"live","price":{"credits":0.02,"usd":0.002,"plus_per_slice":{"credits":0.05,"usd":0.005}},"unit":"per company, plus each slice with data","note":"the employer in depth","call":{"mcp_tool":"get_company","arguments":{"id":686370},"rest":"https://alion.io/mcp/rest/get_company?id=686370"},"human":"https://alion.io/catalog?offer=company.slices&for=job%2Fscholar-rock-sr-scientist-antibody-engineering"},{"id":"market.stats","title":"A market slice: pay, demand and time to fill","status":"live","price":{"credits":1,"usd":0.1},"unit":"per slice","note":"pay, demand and time to fill for this role and place","call":{"mcp_tool":"market_stats"},"human":"https://alion.io/catalog?offer=market.stats&for=job%2Fscholar-rock-sr-scientist-antibody-engineering"},{"id":"job.search","title":"Open jobs by role, technology, place, pay and visa","status":"live","price":{"credits":0.02,"usd":0.002},"unit":"per posting in a list","note":"similar open postings","call":{"mcp_tool":"search_jobs"},"human":"https://alion.io/catalog?offer=job.search&for=job%2Fscholar-rock-sr-scientist-antibody-engineering"},{"id":"company.verify","title":"Is this company real and active right now","status":"pilot","price":null,"unit":"per company","request":{"url":"https://alion.io/catalog/request","method":"POST","body":"{\"offer\": \"company.verify\", \"for\": \"job/scholar-rock-sr-scientist-antibody-engineering\", \"note\": \"what you need it for\"}"},"human":"https://alion.io/catalog?offer=company.verify&for=job%2Fscholar-rock-sr-scientist-antibody-engineering"}]}