{"id":952134,"url":"https://alion.io/job/seaporttherapeutics-associate-director-drug-substance-process-development","title":"Associate Director, Drug Substance Process Development","company":{"id":689800,"name":"Seaport Therapeutics","domain":"seaporttherapeutics.com","url":"https://alion.io/company/seaporttherapeutics","size_band":"201-500","is_staffing_agency":false,"employer_type":"direct","is_intermediary":false,"listed_via":null,"ats_vendor":"Greenhouse","truth_index":null},"role":"Industrial Engineering","role_family":"Industrial Engineering","seniority":"head","employment_type":null,"work_mode":"on_site","remote_scope":null,"remote_scope_basis":null,"remote_working_hours":null,"hiring_geo_confidence":"structured","locations":["Boston, United States"],"countries":["US"],"hiring_countries":[],"hiring_countries_total":0,"salary":{"min":180000,"max":205000,"currency":"USD","period":"year","gross":null,"usd_annual":205000},"salary_estimate":null,"experience_years_min":12,"visa_sponsorship":false,"relocation_package":false,"has_equity":false,"technologies":[{"name":"HPLC","optional":false},{"name":"Mass Spectrometry","optional":false}],"status":"live","first_seen_at":"2026-09-15T18:59:47Z","employer_posted_date":"2026-09-15","last_verified_at":"2026-10-30T06:39:12Z","board_verified":true,"closed_at":null,"days_open":44,"trust":{"level":"ok","repost_count":null,"flags":[],"days_open":44},"description":"Associate Director, Drug Substance Process Development and Manufacturing\nSeaport Therapeutics is a clinical-stage therapeutics company advancing the development of novel neuropsychiatric medicines in areas of high unmet patient needs. The Company has a proven strategy of advancing clinically validated mechanisms previously held back by limitations that are overcome with its proprietary GlyphTM technology platform. All the therapeutic candidates in its pipeline of first and best-in-class medicines are based on the Glyph platform, which is uniquely designed to enable oral bioavailability, bypass first-pass metabolism and reduce hepatotoxicity and other side effects. Seaport is led by an experienced team that invented and advanced important neuropsychiatric medicines and are guided by an extensive network of renowned scientists, clinicians and key opinion leaders. For more information, please visit www.seaporttx.com.\nThe Role\nWe are seeking an Associate Director, Drug Substance Process Development and Manufacturing to join the Technical Operations team.\nThe ideal candidate will have a strong background in process chemistry and manufacturing of small molecule drug substances. In this role, they will lead research development activities and oversee manufacturing at contract organizations to ensure sufficient supply for tox and clinical studies, work closely with Quality, Analytical, Regulatory, and Clinical Supply, provide phase appropriate solutions to meet the program objectives. Key responsibilities include process design, scale-up, and technology transfer in collaboration with Quality and Analytical Services. This role reports to the Sr. Director, API Development and Manufacturing.\nThe successful candidate will embrace a collaborative, innovative culture that embodies our values of service to patients impacted by mental health conditions, with a “we own it” mentality, demonstrating entrepreneurial spirit and technical excellence while fostering teamwork and continuous improvement. This position is based in Boston's Seaport area, with a strong preference for being onsite 4 days per week.\nKey Responsibilities: \nLead the design, planning, and execution of multi-step organic syntheses of small molecule drug substances\nEnsure synthetic route, pharmaceutical form, and compound properties are appropriate for kilo lab and plant manufacturing\nConduct scenario planning to provide analysis and recommendations on development strategy along with associated assumptions and risks\nIdentify and track critical process parameters throughout process and manufacturing development to adequately characterize and measure process/product performance and key quality attributes.\nLead Tech-Transfer and validation activities\nProactively work to manage vendors with regard to scope, timelines, and deliverables\nProvide on-site support to CDMO as necessary\nPresent technical data to cross functional teams and senior management as needed\nCollaborate with Quality on investigation of events and resolve them in a timely manner\nServe as SME in preparation of briefing book, IND/IMPD and NDA applications\nQualifications: \nDegree in chemistry or chemical engineering with experience in pharmaceutical industry, advanced degree preferred:\nBS with 12+ years of experience\nMS. with 10+ years of experience\nPhD with 8+ years of experience\nIn depth knowledge in synthetic route development and process optimization\nExperience with technology transfer and outsourced work on process development\nWorking knowledge of the appropriate analytical techniques such as HPLC, LCMS, NMR etc.\nExperience in API manufacturing associated with small molecules in different phases of clinical development\nFirm knowledge of regulatory guidance applicable to small molecule drug substance\nAbility to work in a complex, dynamic, global environment; thinking strategically and balancing both long and short-term priorities\nAbility to work on multiple projects and meet deadlines as needed; emphasis on results-oriented, strong planning and execution skills\nAbility and willingness to travel up to 20% globally\nAt Seaport, we believe transparency and fairness are key to building a culture of trust, respect, and collaboration. We care deeply about the happiness of our team and strive to ensure our total rewards (monetary and non-monetary) program reflects the value each person brings. The expected salary range for this role is $180,000-$205,000, with the final offer based on experience, market data, and internal equity. We encourage open conversations with our talent acquisition team about compensation early in the process to ensure alignment from the start.","description_format":"text","description_chars":4656,"description_truncated":false,"requirements":{"experience_years_min":12,"management_years_min":null,"team_size_min":null,"manages_managers":false,"education":{"level":"phd","optional":false},"security_clearance":false,"languages":[]},"benefits":["Equity"],"hiring_locations":[],"hiring_excludes":[],"relocation_offered":false,"industries":["Neurology & CNS Therapeutics"],"lifecycle":[{"event":"open","at":"2026-09-16T01:43:05Z"}],"visa":[{"country":"US","licensed_sponsor":true,"evidence":"Filed H-1B visas in the last two years","filings_12m":0,"filings_prev_12m":2,"green_card_filings_12m":0,"median_offered_wage_usd":null,"route":null,"cap_exempt":false,"checked_at":"2026-10-29T16:27:21+00:00","sources":["US Department of Labor: LCA disclosure data (H-1B, H-1B1, E-3)"],"filings_for_role_12m":0}],"liveness":{"score":40,"band":"fade","label":"Fading","p_open":1,"p_active":0.729,"p_room":0.55,"age_days":44,"expected_fill_days":30,"reasons":["conf:3","win:tail"],"computed_at":"2026-10-30T05:48:23Z"},"pay":{"stated_usd_annual":205000,"is_top_pay":true},"html_url":"https://alion.io/job/seaporttherapeutics-associate-director-drug-substance-process-development","json_url":"https://alion.io/job/seaporttherapeutics-associate-director-drug-substance-process-development.json","meta":{"generated_at":"2026-10-30T10:43:11Z","cache_seconds":300,"methodology":"https://alion.io/methodology","terms":"https://alion.io/terms","contact":"https://alion.io/contact","api":"https://alion.io/developers","about":"Alion is a live layer of people, companies and AI agents: who they are, whether they are real and active right now, what they do and how to work with them, readable by people and by agents and paid per call.","catalog":"https://alion.io/catalog.json","usage":{"tier":"crawler_verified","counted_by":"address","units_charged":1,"used_today":15475,"day_limit":null,"remaining_today":null,"minute_limit":300,"resets_at":"2026-10-31T00:00:00Z"}},"offers":[{"id":"company.slices","title":"One company in depth, by slice","status":"live","price":{"credits":0.02,"usd":0.002,"plus_per_slice":{"credits":0.05,"usd":0.005}},"unit":"per company, plus each slice with data","note":"the employer in depth","call":{"mcp_tool":"get_company","arguments":{"id":689800},"rest":"https://alion.io/mcp/rest/get_company?id=689800"},"human":"https://alion.io/catalog?offer=company.slices&for=job%2Fseaporttherapeutics-associate-director-drug-substance-process-development"},{"id":"market.stats","title":"A market slice: pay, demand and time to fill","status":"live","price":{"credits":1,"usd":0.1},"unit":"per slice","note":"pay, demand and time to fill for this role and place","call":{"mcp_tool":"market_stats"},"human":"https://alion.io/catalog?offer=market.stats&for=job%2Fseaporttherapeutics-associate-director-drug-substance-process-development"},{"id":"job.search","title":"Open jobs by role, technology, place, pay and visa","status":"live","price":{"credits":0.02,"usd":0.002},"unit":"per posting in a list","note":"similar open postings","call":{"mcp_tool":"search_jobs"},"human":"https://alion.io/catalog?offer=job.search&for=job%2Fseaporttherapeutics-associate-director-drug-substance-process-development"},{"id":"company.verify","title":"Is this company real and active right now","status":"pilot","price":null,"unit":"per company","request":{"url":"https://alion.io/catalog/request","method":"POST","body":"{\"offer\": \"company.verify\", \"for\": \"job/seaporttherapeutics-associate-director-drug-substance-process-development\", \"note\": \"what you need it for\"}"},"human":"https://alion.io/catalog?offer=company.verify&for=job%2Fseaporttherapeutics-associate-director-drug-substance-process-development"}],"agent":{"mcp":"https://alion.io/mcp/jobs","mcp_open":"https://alion.io/mcp/open","next":[{"tool":"get_job","arguments":{"id":952134}},{"tool":"search_jobs","arguments":{"company":"seaporttherapeutics.com","detail":"compact"}},{"tool":"match_people","arguments":{"job_id":952134},"note":"people open to offers who fit this vacancy"}],"note":"The same data through MCP tools: https://alion.io/mcp/open needs no sign-in (compact searches, postings, people); https://alion.io/mcp with an Alion account has everything. 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