{"id":3911467,"url":"https://alion.io/job/septerna-associate-scientist-protein-sciences","title":"Associate Scientist, Protein Sciences","company":{"id":688376,"name":"Septerna","domain":"septerna.com","url":"https://alion.io/company/septerna","size_band":"51-200","is_staffing_agency":false,"employer_type":"direct","is_intermediary":false,"listed_via":null,"ats_vendor":"Greenhouse","truth_index":null},"role":"Biotech","role_family":"Biotech","seniority":"junior","employment_type":"full_time","work_mode":"on_site","remote_scope":null,"remote_scope_basis":null,"remote_working_hours":null,"hiring_geo_confidence":"structured","locations":["South San Francisco, United States"],"countries":["US"],"hiring_countries":[],"hiring_countries_total":0,"salary":{"min":100000,"max":110000,"currency":"USD","period":"year","gross":null,"usd_annual":110000},"salary_estimate":null,"experience_years_min":4,"visa_sponsorship":false,"relocation_package":false,"has_equity":true,"technologies":[{"name":"Cell Culture","optional":false},{"name":"ELISA","optional":false}],"status":"live","first_seen_at":"2026-11-07T06:38:07Z","employer_posted_date":"2026-11-07","last_verified_at":"2026-11-07T15:29:36Z","board_verified":true,"closed_at":null,"days_open":0,"trust":{"level":"ok","repost_count":null,"flags":[],"days_open":0},"description":"Septerna is a biotechnology company based in South San Francisco, CA on a mission to develop life-changing medicines for patients with the vision to become the industry-leading G protein-coupled receptor (GPCR)-focused drug discovery company. The company’s Native Complex Platform™ recapitulates GPCRs with their native structure, function, and dynamics outside of the cellular context. This approach enables novel access to modern structural and screening technologies used in industrial-scale drug discovery for the entire class of GPCRs. Septerna has an emerging pipeline of GPCR-targeted small molecule programs, many in the Endocrinology space, with potential for growth to target many GPCRs that have been undruggable and unexploited to date.\nWe are excited to expand our multidisciplinary team of individuals focused on creating revolutionary medicines to address the unmet needs of patients. At Septerna we strive to embrace diversity of thought, expertise, and background through collaboration. To join our ambitious team, be prepared to bring your real self to work every day; grow and learn from a talented team of drug hunters, scientists, and business professionals; and contribute your passion, creativity, and energy to accomplish our mission. We share a fearless pursuit of ground-breaking innovations and cultivate an environment where our employees succeed by learning from each other and working as a team.\nWe are committed to the development of meaningful therapeutics for patients with indications of high unmet need. This is a tremendous opportunity to work with talented individuals on the frontlines of therapeutic discovery and development. You will directly help move therapies through preclinical research, positioning them for success in the clinic. The successful candidate will add their passion, unique talents, and expertise to a dynamic team motivated to discover new disease-modifying therapeutics for patients in a fast-paced environment.\nFor more information see: www.septerna.com.\nAbout The Role\n We are seeking passionate and creative individuals who want to contribute to Septerna’s mission to utilize innovative drug discovery technologies for GPCR targets. The ideal candidate will have experience in eukaryotic cell culture of suspension-based cell lines including HEK293, including cell line maintenance, transfection, and protein expression.\nThe chosen candidate will be working in a collaborative team contributing to improvements in protein expression and purification to support production and characterization of proteins for use in structural biology, biophysics, and small molecule drug discovery. This position offers the unique opportunity to join an innovative well-funded biotechnology company and to contribute to its long-term success. \nThe position is based in South San Franscisco, CA. Title and compensation commensurate with experience.\nResponsibilities \nPerform as a hands-on cell culturist to help fully enable Septerna’s Native Complex™ \nCarry out continuous cell line maintenance primarily on Expi293 suspension cell lines, but also of insect cell lines when required.\nPerform transient transfections, stable pool selection, and cell line cryopreservation of Expi293 cell lines.\nCarry out small- and large-scale cell culture for production of recombinant proteins\nAssist when needed with protein purification and protein-related assay technologies including ELISAs, SDS-PAGE, and DSF.\nWork collaboratively with Discovery Biology teams in ensuring proper prioritization and timelines of cell culture requests.\nLaboratory notebooking, data analysis and documentation. \nQualifications\nBS/MS with a minimum of 4+ years of hands-on relevant experience in a biotechnology or pharmaceutical setting.\n1+ years demonstrated expertise in high-quality mammalian cell culture of suspension cell lines including HEK293, preferably using the Expi293 system.\nExperience in transient transfection, cell line maintenance, cell counting, stable pool selection, and cell cryopreservation.\nPrior experience with ELISA assays and basic protein techniques (SDS-PAGE, Nanodrop, DSF) is desirable.\nAbility to organize multiple projects to ensure delivery of reagents with appropriate prioritization and timelines\nDemonstrated experience working collaboratively in a team-oriented environment\nClear and effective verbal and written communication skills\nThe anticipated salary range for candidates who will work in South San Francisco, CA is $100,000 - $110,000. Individual pay may vary based on additional factors, including, and without limitation, job-related skills, experience, work location and relevant education or training. Septerna's compensation package also includes benefits, stock options, and annual target bonus for full-time positions.\nNote to Employment Agencies: Please do not forward any agency resumes. The company will not be responsible for any fees related to resumes that are unsolicited. We are an Equal Opportunity employer and will consider all qualified applicants for employment without regard to race, color, religion, sex, sexual orientation, gender identity, national origin, protected veteran status, or disability status. Septerna participates in the E-Verify program. California Consumer Privacy Act Privacy Notice For Job Applicants. If you are a California resident, click here for our CCPA Notice.","description_format":"text","description_chars":5374,"description_truncated":false,"requirements":{"experience_years_min":4,"management_years_min":null,"team_size_min":null,"manages_managers":false,"education":null,"security_clearance":false,"languages":[]},"benefits":["Stock options"],"hiring_locations":[],"hiring_excludes":[],"relocation_offered":false,"industries":["Drug Discovery","Oncology Therapeutics"],"lifecycle":[{"event":"open","at":"2026-11-07T07:39:42Z"}],"visa":[{"country":"US","licensed_sponsor":true,"adverts_offering_sponsorship_24m":0,"sanctioned_now":false,"evidence":"H-1B filings in 12 months: 3","filings_12m":3,"filings_prev_12m":1,"green_card_filings_12m":0,"median_offered_wage_usd":162500,"route":null,"cap_exempt":false,"checked_at":"2026-11-07T07:57:00+00:00","sources":["US Department of Labor: LCA disclosure data (H-1B, H-1B1, E-3)"],"filings_for_role_12m":0}],"liveness":{"score":86,"band":"hot","label":"Hiring now","p_open":1,"p_active":0.86,"p_room":1,"age_days":0,"expected_fill_days":29,"reasons":["conf:1","win:early","comp:junior"],"computed_at":"2026-11-07T17:10:25Z"},"pay":{"stated_usd_annual":110000,"is_top_pay":true},"html_url":"https://alion.io/job/septerna-associate-scientist-protein-sciences","json_url":"https://alion.io/job/septerna-associate-scientist-protein-sciences.json","meta":{"generated_at":"2026-11-07T17:10:25Z","cache_seconds":300,"methodology":"https://alion.io/methodology","terms":"https://alion.io/terms","contact":"https://alion.io/contact","api":"https://alion.io/developers","about":"Alion is a live layer of people, companies and AI agents: who they are, whether they are real and active right now, what they do and how to work with them, readable by people and by agents and paid per call.","catalog":"https://alion.io/catalog.json","usage":{"tier":"crawler_verified","counted_by":"address","units_charged":1,"used_today":24860,"day_limit":null,"remaining_today":null,"minute_limit":300,"resets_at":"2026-11-08T00:00:00Z"}},"offers":[{"id":"company.slices","title":"One company in depth, by slice","status":"live","price":{"credits":0.02,"usd":0.002,"plus_per_slice":{"credits":0.05,"usd":0.005}},"unit":"per company, plus each slice with data","note":"the employer in depth","call":{"mcp_tool":"get_company","arguments":{"id":688376},"rest":"https://alion.io/mcp/rest/get_company?id=688376"},"human":"https://alion.io/catalog?offer=company.slices&for=job%2Fsepterna-associate-scientist-protein-sciences"},{"id":"market.stats","title":"A market slice: pay, demand and time to fill","status":"live","price":{"credits":1,"usd":0.1},"unit":"per slice","note":"pay, demand and time to fill for this role and place","call":{"mcp_tool":"market_stats"},"human":"https://alion.io/catalog?offer=market.stats&for=job%2Fsepterna-associate-scientist-protein-sciences"},{"id":"job.search","title":"Open jobs by role, technology, place, pay and visa","status":"live","price":{"credits":0.02,"usd":0.002},"unit":"per posting in a list","note":"similar open postings","call":{"mcp_tool":"search_jobs"},"human":"https://alion.io/catalog?offer=job.search&for=job%2Fsepterna-associate-scientist-protein-sciences"},{"id":"company.verify","title":"Is this company real and active right now","status":"pilot","price":null,"unit":"per company","request":{"url":"https://alion.io/catalog/request","method":"POST","body":"{\"offer\": \"company.verify\", \"for\": \"job/septerna-associate-scientist-protein-sciences\", \"note\": \"what you need it for\"}"},"human":"https://alion.io/catalog?offer=company.verify&for=job%2Fsepterna-associate-scientist-protein-sciences"}],"agent":{"mcp":"https://alion.io/mcp/jobs","mcp_open":"https://alion.io/mcp/open","next":[{"tool":"get_job","arguments":{"id":3911467}},{"tool":"search_jobs","arguments":{"company":"septerna.com","detail":"compact"}},{"tool":"match_people","arguments":{"job_id":3911467},"note":"people open to offers who fit this vacancy"}],"note":"The same data through MCP tools: https://alion.io/mcp/open needs no sign-in (compact searches, postings, people); https://alion.io/mcp with an Alion account has everything. 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