Head of AI/ML (Director/VP) - VC Backed Startups

Join SignalFire’s Talent Network for Head of AI/ML (Director/VP) Roles at VC-Backed Startups

This is not an application for a specific job. Instead, this is a way to get on the radar of VC-backed startups that are actively hiring AI and machine learning leaders. If you have any questions, please direct inquiries to [email protected].

At SignalFire, we partner with top early-stage startups that are shaping the future of technology. Our portfolio spans 200+ innovative companies across AI, cybersecurity, healthtech, fintech, developer tools, and enterprise SaaS.

We’re looking to connect with exceptional Heads of AI/ML, including Director- and VP-level leaders, who are excited about defining AI strategy, building high-performing teams, and translating emerging technologies into differentiated products and business outcomes.

By joining SignalFire’s Talent Network, your profile will be shared with our portfolio companies, giving you visibility into exclusive early-stage opportunities that may not be publicly listed.

Who Should Join?

We’re looking for leaders who are:

Passionate about building AI-native products and applying machine learning to meaningful customer problems

Experienced in defining AI/ML strategy and leading teams from research and experimentation through production deployment

Excited to partner with founders, product leaders, and engineering teams to shape company and product direction

Comfortable balancing technical depth, organizational leadership, and commercial impact

Typical Roles & Responsibilities

• Define and execute the company’s AI and machine learning strategy in alignment with product and business priorities

• Build, lead, and develop high-performing teams across machine learning, applied AI, data science, and research

• Identify high-impact opportunities to apply AI and translate them into differentiated product capabilities

• Lead the development, evaluation, deployment, and continuous improvement of production ML systems

• Establish technical standards for model quality, experimentation, reliability, observability, and responsible AI

• Guide decisions across model selection, fine-tuning, retrieval, data strategy, infrastructure, and build-versus-buy tradeoffs

• Partner with engineering and product leaders to integrate AI capabilities into scalable customer-facing products

• Oversee data collection, labeling, governance, and feedback loops required to improve model performance

• Evaluate emerging models, research, and tooling while maintaining a practical focus on customer and business value

• Communicate AI strategy, capabilities, limitations, and investment priorities to executive teams, boards, customers, and partners

• Support recruiting, organizational design, and workforce planning for the company’s AI and ML functions

• Help establish safeguards around privacy, security, bias, explainability, and regulatory requirements

Common Qualifications

While each startup has its own hiring criteria, many Head of AI/ML roles in our network look for:

• 10+ years of experience across machine learning, artificial intelligence, data science, or software engineering, including meaningful leadership experience

• Proven experience building and scaling AI/ML teams in startup or high-growth technology environments

• Track record of developing and deploying machine learning systems into production

• Strong technical foundation across modern ML methods, model evaluation, data pipelines, and production infrastructure

• Experience applying large language models, generative AI, deep learning, or traditional machine learning to real-world products

• Ability to connect technical investments to product differentiation, customer outcomes, and business value

• Experience partnering closely with product, engineering, data, and go-to-market leaders

• Strong judgment around model quality, latency, cost, scalability, safety, and reliability

• Ability to operate effectively across hands-on technical leadership, team management, and executive-level strategy

• Advanced degree in computer science, machine learning, statistics, mathematics, or a related field may be preferred but is not always required

Technologies You Might Work With:

• Languages & Frameworks: Python, PyTorch, TensorFlow, JAX, scikit-learn, Hugging Face

• Generative AI: Large language models, multimodal models, retrieval-augmented generation, fine-tuning, prompt engineering, agentic systems

• Data & Infrastructure: Spark, Databricks, Snowflake, Kafka, Airflow, vector databases, feature stores

• Cloud & MLOps: AWS, GCP, Azure, Kubernetes, Docker, MLflow, Weights & Biases, SageMaker, Vertex AI

• Models & Platforms: OpenAI, Anthropic, Google, Meta, open-source foundation models, proprietary model architectures

What Happens Next?

• Submit your application to join SignalFire’s Talent Ecosystem.

• We review applications on an ongoing basis to identify strong candidates.

• If there’s a match, a SignalFire talent partner or a leader from one of our startups may reach out directly.

• No match yet? We’ll keep your profile on file for future AI and machine learning leadership roles across our portfolio.