{"id":1736210,"url":"https://alion.io/job/synthego-process-development-engineer","title":"Process Development Engineer","company":{"id":2016203,"name":"Synthego","domain":"synthego.com","url":"https://alion.io/company/synthego","size_band":null,"is_staffing_agency":false,"employer_type":"direct","is_intermediary":false,"listed_via":null,"ats_vendor":"Lever","truth_index":null},"role":"Biotech","role_family":"Biotech","seniority":"junior","employment_type":"full_time","work_mode":"on_site","remote_scope":null,"remote_scope_basis":null,"remote_working_hours":null,"hiring_geo_confidence":"structured","locations":["Redwood City, United States"],"countries":["US"],"hiring_countries":[],"hiring_countries_total":0,"salary":{"min":105000,"max":115000,"currency":"USD","period":"year","gross":null,"usd_annual":115000},"salary_estimate":null,"experience_years_min":2,"visa_sponsorship":false,"relocation_package":false,"has_equity":false,"technologies":[{"name":"Mass Spectrometry","optional":false},{"name":"Python","optional":false},{"name":"SQL","optional":false},{"name":"qPCR","optional":true}],"status":"live","first_seen_at":"2026-10-01T18:58:35Z","employer_posted_date":"2026-10-01","last_verified_at":"2026-11-01T01:26:54Z","board_verified":true,"closed_at":null,"days_open":30,"trust":{"level":"ok","repost_count":null,"flags":[],"days_open":30},"description":"Synthego is enabling genome engineering at scale with a blend of scientific instrumentation, industrial automation, and data science. Our team of scientists and engineers are putting multidisciplinary fields together to solve problems that no one field can tackle alone.\nWe are searching for a motivated and enthusiastic individual to join our Chemistry Development team to improve our oligonucleotide manufacturing process and to directly contribute to launching new oligonucleotide products. As a Process Development Engineer at Synthego, you will have direct responsibility for the development of new techniques for synthesis and purification of RNA and DNA from nanomole to millimole scales. Primary goals include scaling manufacturing processes, improving cost and margin, improving quality of oligonucleotide products, and reducing production times. This role will include developing in both a research and clinical environment, as well as transferring technology into the manufacturing lines. With a focus on the successful introduction and adoption of new technologies in operations, this role will collaborate closely with the hardware, software, operations, quality, and product teams.\nWhat You'll Do:\nDesign, develop, and implement methods to scale oligonucleotide synthesis and purification \nSynthesize, purify and analyze oligonucleotides to specifications, using proprietary and commercial instrumentation \nAnalyze data from assays such as UV, chromatograms and mass spectrometry for optimizing experimental conditions and determining root causes of failures \nWork alongside a cross-functional group of Chemists, Engineers, and Scientists to execute developmental processes and collaborate on designed experiments. \nConduct experimentation using automated instrumentation and liquid handling equipment \nWrite development protocols and reports and regularly present findings to interdepartmental stakeholders \nConduct IQ/OQ/PQ for new instrumentation acquired for development projects \nPractice continuous improvement by contributing ideas and suggestions to new and existing processes \nGenerate and maintain records or documents in a detailed and consistent manner \nAssist with Quality data management, including writing new or updating Standard Operating Procedures, Batch Records, and Change Control documents \nWork with vendors to acquire reagents, consumables, or instrumentation as needed for development efforts \nTrain others on new or updated processes and procedures \nAbout You:\nBS in Chemistry, Chemical Engineering, Bio-engineering or a similar field \n2-5 years of industry experience within a research/manufacturing/production environment, preferably in a small company/start-up setting \nDirect experience in the synthesis and analysis of oligonucleotide products \nExperience in data analysis with languages such as Python, SQL. \nUnderstanding of aseptic handling techniques, including liquid handling, pipetting, reagent preparation, and consumables. \nExperience using larger scale instrumentation such as HPLCs, oligonucleotide or peptide synthesizers, tangential flow filtration, and/or liquid handlers. \nStrong desire to work in a fast-paced, collaborative start-up environment \nDemonstrates strong interpersonal and communication skills (both written and oral) \nDemonstrates ability to work independently and as part of a team to curate and execute development projects. \nNice to Have:\nDeep knowledge of oligonucleotide chemistry or reagent manufacturing, specifically using fluorophores, quenchers, or other oligonucleotide modifiers \nFamiliar with qPCR \nFamiliar with fluorescence assays and how to create functional tests for newly developed products \nFamiliar with biotechnical instrumentation in aspects such as coding new methods, data analysis pipeline, servicing, etc \nCompany Perks & Benefits:\nMedical, dental, and vision benefits \n401k Program \nCatered meals on Tuesday and Thursday \nPaid parental leave \nFlexible paid 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