{"id":1562323,"url":"https://alion.io/job/topos-bio-ml-research-scientist","title":"ML Research Scientist","company":{"id":2309199,"name":"Topos Bio","domain":"toposbio.ai","url":"https://alion.io/company/toposbio","size_band":"11-50","is_staffing_agency":false,"employer_type":"direct","is_intermediary":false,"listed_via":null,"ats_vendor":"Ashby","truth_index":null},"role":"AI/ML","role_family":"AI/ML","seniority":null,"employment_type":"full_time","work_mode":"on_site","remote_scope":null,"remote_scope_basis":null,"remote_working_hours":null,"hiring_geo_confidence":"structured","locations":["San Francisco, United States"],"countries":["US"],"hiring_countries":[],"hiring_countries_total":0,"salary":null,"salary_estimate":{"min_usd":161000,"max_usd":356000,"period":"year","method":"role_country_seniority_unknown","sample_n":4194},"experience_years_min":null,"visa_sponsorship":false,"relocation_package":false,"has_equity":false,"technologies":[{"name":"Machine Learning","optional":false}],"status":"live","first_seen_at":"2026-09-30T03:17:00Z","employer_posted_date":"2026-09-30","last_verified_at":"2026-10-25T21:52:59Z","board_verified":true,"closed_at":null,"days_open":25,"trust":{"level":"ok","repost_count":null,"flags":[],"days_open":25},"description":"Topos Bio\nTopos Bio is developing computational methods to drug intrinsically disordered proteins.\nWe're seeking a research scientist to develop and optimize ML methods that bridge simulation, protein modeling, and small molecule design. This role requires both strong machine learning foundations and the ability to work at the interface of computational biology, structural modeling, and chemistry.\nWhat you will do\nDevelop generative models for protein conformational ensembles trained on simulation and experimental data\n\nBuild novel ML architectures for ensemble-based affinity prediction and generative chemistry\n\nAdapt methods from research literature to disordered protein targets\n\nDesign scalable training pipelines for high-throughput experimentation\n\nCollaborate with computational and experimental scientists to validate models against biophysical data\n\nWhat we are looking for\nStrong foundation in machine learning theory and implementation\n\nDeep understanding of modern generative models with application to the sciences\n\nBackground in computational sciences involving biology and chemistry\n\nPreferred\nMS or PhD in machine learning with application to computational science\n\nStrong publication record\n\nExperience with molecular simulation and protein modeling","description_format":"text","description_chars":1273,"description_truncated":false,"requirements":{"experience_years_min":null,"management_years_min":null,"team_size_min":null,"manages_managers":false,"education":{"level":"phd","optional":false},"security_clearance":false,"languages":[]},"benefits":[],"hiring_locations":[],"hiring_excludes":[],"relocation_offered":false,"industries":["Drug Discovery","AI for Science"],"lifecycle":[{"event":"open","at":"2026-10-01T04:29:08Z"}],"visa":[{"country":"US","licensed_sponsor":true,"evidence":"Filed H-1B visas in the last two years","filings_12m":0,"filings_prev_12m":1,"green_card_filings_12m":0,"median_offered_wage_usd":null,"route":null,"cap_exempt":false,"checked_at":"2026-10-15T11:24:14+00:00","sources":["US Department of Labor: LCA disclosure data (H-1B, H-1B1, E-3)"],"filings_for_role_12m":0}],"liveness":{"score":54,"band":"ok","label":"Likely open","p_open":1,"p_active":0.598,"p_room":0.9,"age_days":25,"expected_fill_days":49,"reasons":["conf:3","win:mid"],"computed_at":"2026-10-25T05:49:26Z"},"pay":null,"html_url":"https://alion.io/job/topos-bio-ml-research-scientist","json_url":"https://alion.io/job/topos-bio-ml-research-scientist.json","meta":{"generated_at":"2026-10-25T22:09:57Z","cache_seconds":300,"methodology":"https://alion.io/methodology","terms":"https://alion.io/terms","contact":"https://alion.io/contact","api":"https://alion.io/developers","about":"Alion is a live layer of people, companies and AI agents: who they are, whether they are real and active right now, what they do and how to work with them, readable by people and by agents and paid per call.","catalog":"https://alion.io/catalog.json","usage":{"tier":"crawler_verified","counted_by":"address","units_charged":1,"used_today":31308,"day_limit":null,"remaining_today":null,"minute_limit":300,"resets_at":"2026-10-26T00:00:00Z"}},"offers":[{"id":"company.slices","title":"One company in depth, by slice","status":"live","price":{"credits":0.02,"usd":0.002,"plus_per_slice":{"credits":0.05,"usd":0.005}},"unit":"per company, plus each slice with data","note":"the employer in depth","call":{"mcp_tool":"get_company","arguments":{"id":2309199},"rest":"https://alion.io/mcp/rest/get_company?id=2309199"},"human":"https://alion.io/catalog?offer=company.slices&for=job%2Ftopos-bio-ml-research-scientist"},{"id":"market.stats","title":"A market slice: pay, demand and time to fill","status":"live","price":{"credits":1,"usd":0.1},"unit":"per slice","note":"pay, demand and time to fill for this role and place","call":{"mcp_tool":"market_stats"},"human":"https://alion.io/catalog?offer=market.stats&for=job%2Ftopos-bio-ml-research-scientist"},{"id":"job.search","title":"Open jobs by role, technology, place, pay and visa","status":"live","price":{"credits":0.02,"usd":0.002},"unit":"per posting in a list","note":"similar open postings","call":{"mcp_tool":"search_jobs"},"human":"https://alion.io/catalog?offer=job.search&for=job%2Ftopos-bio-ml-research-scientist"},{"id":"company.verify","title":"Is this company real and active right now","status":"pilot","price":null,"unit":"per company","request":{"url":"https://alion.io/catalog/request","method":"POST","body":"{\"offer\": \"company.verify\", \"for\": \"job/topos-bio-ml-research-scientist\", \"note\": \"what you need it for\"}"},"human":"https://alion.io/catalog?offer=company.verify&for=job%2Ftopos-bio-ml-research-scientist"}]}