{"id":2144425,"url":"https://alion.io/job/tr1x-director-senior-director-program-management","title":"Director / Senior Director, Program Management","company":{"id":687396,"name":"Tr1X","domain":"tr1x.com","url":"https://alion.io/company/tr1x","size_band":"51-200","is_staffing_agency":false,"employer_type":"direct","is_intermediary":false,"listed_via":null,"ats_vendor":"Greenhouse","truth_index":null},"role":"Science & Research","role_family":"Science & Research","seniority":"head","employment_type":null,"work_mode":"on_site","remote_scope":null,"remote_scope_basis":null,"remote_working_hours":null,"hiring_geo_confidence":"structured","locations":["San Diego, United States"],"countries":["US"],"hiring_countries":[],"hiring_countries_total":0,"salary":{"min":210000,"max":230000,"currency":"USD","period":"year","gross":null,"usd_annual":230000},"salary_estimate":null,"experience_years_min":10,"visa_sponsorship":false,"relocation_package":false,"has_equity":true,"technologies":[],"status":"live","first_seen_at":"2026-10-06T15:28:06Z","employer_posted_date":"2026-10-12","last_verified_at":"2026-10-15T04:16:21Z","board_verified":true,"closed_at":null,"days_open":8,"trust":{"level":"ok","repost_count":null,"flags":[],"days_open":8},"description":"About Tr1X\nTr1X is a clinical-stage biotechnology company developing engineered Tr1 cell therapies to restore immune balance in autoimmune and inflammatory diseases. Leveraging the unique biology of Tr1 cells, the company is advancing a pipeline of off-the-shelf allogeneic and in vivo CAR-Tr1 therapies designed to deliver targeted immunoregulation and address diseases driven by immune dysfunction, including transplant-related complications. Founded by pioneers in the discovery of Tr1 cells, Tr1X, Inc. is focused on developing durable, potentially curative therapies for conditions with high unmet need. For more information, visit www.tr1x.bio.\nPosition Summary\nThe Director/Senior Director, Program Management provides strategic leadership and performs hands-on operational activities supporting cell therapy programs in autoimmune indications. This individual aligns cross-functional teams, manages dependencies and risks, and ensures programs deliver against milestones and organizational objectives. The Director/Senior Director partners closely with Clinical Development, Clinical Operations, Regulatory, Technical Operations and R&D, along with external partners to drive execution of complex preclinical and clinical programs from early development through registrational studies.\nKey Responsibilities\nTranslate program strategy into integrated timelines, milestones, and deliverables, ensuring coordination across all contributing functions.\nProvide program/project management expertise and support to advance Tr1X's Tr1, CAR-Tr1 and in vivo cell therapy programs.\nProvide program management of one or more highly complex R&D programs and/or high-profile partnerships.\nCommunicate with project team members, management leadership team, department heads, and key stakeholders including KOLs.\nTrack and monitor key milestones and decision points to drive delivery of project objectives.\nDevelop and refine tools for project governance and program timelines, as well as the communication of program KPIs, risks and achievements.\nManage the interfaces between cross-functional teams and ensure effective handoff and communication between department functions.\nLead cross-functional program management activities supporting autoimmune clinical development programs.\nDevelop and maintain integrated clinical development plans, timelines, milestones, budgets, and risk management strategies across multiple functional areas.\nPartner with Clinical and senior leadership to support development strategy, indication prioritization, and pipeline programming.\nEnsure program activities support regulatory milestones including INDs, protocol amendments, health authority interactions, and potential BLA/MAA submissions.\nPartner with Clinical Operations to proactively identify enrollment, operational, and site-performance risks and implement mitigation strategies to ensure on time and on budget study recruitment.\nEnsure seamless coordination between clinical and CMC activities supporting cell therapy manufacturing, supply planning, patient scheduling, and supply chain/delivery logistics.\nFacilitate governance meetings, cross-functional team meetings including program team meetings, clinical strategy meetings and executive program reviews.\nCollaborate with Clinical Development, Regulatory and Medical Directors on protocol strategy, clinical endpoints, efficacy measures, biomarkers, and patient-reported outcomes relevant to autoimmune studies.\nSupport competitive intelligence activities and maintain awareness of evolving autoimmune treatment landscapes, clinical trial designs, and emerging therapies.\nPartner with R&D, Clinical Development and Medical Writing teams to support preparation of grants, posters, presentations and external-facing materials.\nEstablish and maintain program dashboards, KPIs, and governance frameworks to ensure transparency and accountability.\nSupport budget forecasting, scenario planning, and resource prioritization across the entire pipeline.\nPerform other responsibilities based on business needs.\nRequired Qualifications & Experience\nA minimum BA/BS and 10+ yrs in a relevant Program/Project management role supporting drug development; advanced degree (Ph.D., MS, MD) and/or PM Certification strongly preferred.\nExceptional communication skills (in person and written word) and the ability to interact and directly engage with a diverse group of individuals.\nExtensive experience managing and partnering with contract development and manufacturing organizations in the cell and gene therapy space.\nExperience on the sponsor side with cell or gene therapy development programs required.\nExperience applying the principles, concepts, practices, and standards of project management for drug development.\nAbility to understand and communicate scientific and business elements associated with Tr1X's engineered Tr1 Treg cell therapies is a must.\nStrong skills in management of external stakeholders and ability to influence and guide them toward decisions and outcomes that support company goals. \nExcellent interpersonal skills, ability to develop relationships with key internal and external stakeholders, and effective conflict management skills.\nResults and detail-oriented for achievement of program timeline and deliverables; self-motivated, ability to work with minimal supervision.\nAbility to adapt and perform in a fast-paced environment under tight deadlines.\nStrong analytical and problem-solving capabilities.\nOther Requirements\nLegally authorized to work for any employer in the U.S.\nPosition is on-site in San Diego, CA\nThe job responsibilities and requirements provided above are intended to describe the general nature of the work performed by individuals assigned to this job classification. It is not intended to be an exhaustive list of all duties and requirements. Tr1X retains the right to add, change, or delete duties, education, experience or any other requirements of the position at any time.\nWorking at Tr1X\nAt Tr1X, our team is united by a singular shared mission: to transform patients’ lives through breakthrough science. We are a group of skilled experts driven by urgency, innovation and a collaborative spirit. Our culture thrives on excellence, positivity, persistence and the agility to tackle new challenges head-on. With an unwavering commitment to patients, science and one another, we foster an environment where team members feel engaged, supported and empowered to make a meaningful impact. We envision a world where autoimmune diseases are not just being treated but are cured.\nBase Pay Range Anticipated: $210,000 - $230,000 (Director); $250,000 - $280,000 (Sr. Director)\nTr1X considers a variety of factors to determine salary such as education, years of experience, time in the position level, training, knowledge, skills, geographic location, and the market value of the position.\nCompensation and Benefits\nTr1X provides a fair and competitive total rewards program that includes base salary; discretionary annual target bonus; incentive stock options; 401(k) retirement plan with company contribution; health and welfare insurance plans for employees (and their families) that include medical, dental, vision, long-term and short-term disability, and life insurance; paid time off (PTO); and paid holidays.\nTr1X embraces a diverse, open, and inclusive environment and believes a strong culture connection is key to success. Tr1X is committed to fairness in recruitment, hiring, transfer, promotion or any other employment practice without regard to race, color, citizenship, national origin, ancestry, religion, sex, pregnancy, marital status, sexual orientation, gender, gender identity and expression, age, physical and medical disability, medical condition, genetic information, political affiliation, protected veteran status, or any other characteristic protected by law. If you are an individual needing assistance to complete an employment application or would like to request an accommodation, please contact the Human Resources department at .\nNotice to Employment Agencies\nThe Tr1X talent acquisition program is managed through internal resources, and unsolicited referrals and resumes are not accepted from employment agencies, unless advance written authorization is granted from the human resources department. Tr1X shall not be liable for any fees arising from any unsolicited or unauthorized candidate information received relative to position vacancies.","description_format":"text","description_chars":8477,"description_truncated":false,"requirements":{"experience_years_min":10,"management_years_min":null,"team_size_min":null,"manages_managers":false,"education":{"level":"phd","optional":false},"security_clearance":false,"languages":[]},"benefits":["Life insurance","Retirement plans","Stock options"],"hiring_locations":[],"hiring_excludes":[],"relocation_offered":false,"industries":["Cell & Gene Therapy","Immunology & Inflammation Therapeutics"],"lifecycle":[{"event":"open","at":"2026-10-09T04:04:20Z"}],"visa":[],"liveness":{"score":85,"band":"hot","label":"Hiring now","p_open":1,"p_active":0.85,"p_room":1,"age_days":7,"expected_fill_days":26,"reasons":["conf:1","win:early"],"computed_at":"2026-10-14T06:34:16Z"},"pay":{"stated_usd_annual":230000,"is_top_pay":false},"html_url":"https://alion.io/job/tr1x-director-senior-director-program-management","json_url":"https://alion.io/job/tr1x-director-senior-director-program-management.json","meta":{"generated_at":"2026-10-15T04:16:39Z","cache_seconds":300,"methodology":"https://alion.io/methodology","terms":"https://alion.io/terms","contact":"https://alion.io/contact","api":"https://alion.io/developers","about":"Alion is a live layer of people, companies and AI agents: who they are, whether they are real and active right now, what they do and how to work with them, readable by people and by agents and paid per call.","catalog":"https://alion.io/catalog.json","usage":{"tier":"crawler_verified","counted_by":"address","units_charged":1,"used_today":6219,"day_limit":null,"remaining_today":null,"minute_limit":300,"resets_at":"2026-10-16T00:00:00Z"}},"offers":[{"id":"company.slices","title":"One company in depth, by slice","status":"live","price":{"credits":0.02,"usd":0.002,"plus_per_slice":{"credits":0.05,"usd":0.005}},"unit":"per company, plus each slice with data","note":"the employer in depth","call":{"mcp_tool":"get_company","arguments":{"id":687396},"rest":"https://alion.io/mcp/rest/get_company?id=687396"},"human":"https://alion.io/catalog?offer=company.slices&for=job%2Ftr1x-director-senior-director-program-management"},{"id":"market.stats","title":"A market slice: pay, demand and time to fill","status":"live","price":{"credits":1,"usd":0.1},"unit":"per slice","note":"pay, demand and time to fill for this role and place","call":{"mcp_tool":"market_stats"},"human":"https://alion.io/catalog?offer=market.stats&for=job%2Ftr1x-director-senior-director-program-management"},{"id":"job.search","title":"Open jobs by role, technology, place, pay and visa","status":"live","price":{"credits":0.02,"usd":0.002},"unit":"per posting in a list","note":"similar open postings","call":{"mcp_tool":"search_jobs"},"human":"https://alion.io/catalog?offer=job.search&for=job%2Ftr1x-director-senior-director-program-management"},{"id":"company.verify","title":"Is this company real and active right now","status":"pilot","price":null,"unit":"per company","request":{"url":"https://alion.io/catalog/request","method":"POST","body":"{\"offer\": \"company.verify\", \"for\": \"job/tr1x-director-senior-director-program-management\", \"note\": \"what you need it for\"}"},"human":"https://alion.io/catalog?offer=company.verify&for=job%2Ftr1x-director-senior-director-program-management"}]}