{"id":1259705,"url":"https://alion.io/job/twist-bioscience-sr-manager-protein-sciences","title":"Sr Manager Protein Sciences","company":{"id":1814479,"name":"Twist Bioscience","domain":"twistbioscience.com","url":"https://alion.io/company/twistbioscience","size_band":null,"is_staffing_agency":false,"employer_type":"direct","is_intermediary":false,"listed_via":null,"ats_vendor":"Greenhouse","truth_index":{"grade":"B","score":76,"open_postings":8,"ghost_share":0,"stale_share":0.875,"repost_share":0.125,"time_to_fill_p50_days":37,"computed_at":"2026-11-11T05:49:22Z"}},"role":"Biotech","role_family":"Biotech","seniority":"senior","employment_type":null,"work_mode":"on_site","remote_scope":null,"remote_scope_basis":null,"remote_working_hours":null,"hiring_geo_confidence":"structured","locations":["South San Francisco, United States"],"countries":["US"],"hiring_countries":[],"hiring_countries_total":0,"salary":{"min":189000,"max":224000,"currency":"USD","period":"year","gross":null,"usd_annual":224000},"salary_estimate":null,"experience_years_min":5,"visa_sponsorship":false,"relocation_package":false,"has_equity":false,"technologies":[{"name":"Antibody Engineering","optional":false},{"name":"Cell Culture","optional":false},{"name":"Python","optional":true}],"status":"live","first_seen_at":"2026-08-28T16:51:07Z","employer_posted_date":"2026-09-29","last_verified_at":"2026-11-11T19:01:12Z","board_verified":true,"closed_at":null,"days_open":75,"trust":{"level":"ok","repost_count":null,"flags":[],"days_open":75},"description":"Sr. Manager - Protein Sciences R&D (South San Francisco, CA)\nSummary\nTwist is searching for an RnD scientist/manager with experience in cell biology and protein expression and purification, with an emphasis on antibodies, to lead and enhance our protein sciences capabilities. \nWe're looking for a curious, technically deep, and driven scientist who can operate as both a hands-on bench scientist and a builder of people and process. You will start as an individual contributor, personally executing and improving core workflows, while simultaneously defining the technical roadmap, hiring, and building a team around you. As the team grows, you will continue to spend meaningful time at the bench and on experimental design. We are looking for people who have deep technical knowledge and a strong drive to get things done. \nJob title and compensation will be determined based on several factors, including, but not limited to, the candidate's years of experience, skills, knowledge, and abilities.\nKey Responsibilities:\nDevelop small- and medium-scale antibody production workflows, including various formats (single-chain, IgG, multi-specific), culture systems, and purification methods\nImprove all aspects of the end-to-end antibody development workflow: construct design, cell line development, cell culture, purification, and analytics\nBuild from the ground up and manage a team of scientists and RAs that will aid you in your work \nIndependently design and execute experiments, and analyze experimental data\nMove projects forward efficiently / manage time and resources effectively / prioritize tasks in accordance with the company’s goals\nDocument and communicate results clearly and succinctly\nBe helpful/collaborative/proactive\nStay up to date with new developments, companies, and technologies\nBe the ultimate subject matter expert, and understand all aspects of your work as profoundly as possible, including details that are adjacent to your projects\nWhat You’ll Bring to the Team :\nDeep hands-on experience designing, expressing, and optimizing monoclonal antibodies, with demonstrated understanding of Fc structure-function relationships (effector function, stability, manufacturability).\nProven experience with bispecific antibody architectures, including but not limited to:\nKnob-in-hole, CrossMab, common light chain, or similar\nChain pairing control and mispairing mitigation\nExperience generating and optimizing stable mammalian cell lines (CHO preferred):\nVector design, promoter/selection strategies\nClone screening, productivity optimization, and stability assessment\nStrong understanding of transient vs stable expression tradeoffs and when to deploy each during platform development.\nExperience improving expression yields and product quality through sequence, vector, and host engineering.\nDemonstrated ability to build, improve, and standardize antibody generation workflows, not just execute existing SOPs.\nExperience developing high-throughput or semi-automated workflows for expression, purification, and screening.\nStrong understanding of platform robustness, reproducibility, and cost drivers.\nHands-on experience with antibody characterization methods, such as:\nSEC, CE-SDS\nBinding kinetics (BLI or SPR)\nBasic biophysical profiling (DSF, DLS)\nStrong mechanistic understanding of antibody biology, structure, and expression bottlenecks\nExperience designing platforms that support multiple antibody modalities (mAbs, bispecifics, Fc-engineered variants)\nA track record of successful and creative method development\n Qualifications:\nPhD in Cell Biology, Biochemistry, or a closely related field\n5+ years of experience in protein sciences \n5 years of management experience\nHands-on experience working with antibody expression and purification\nExperience with liquid-handling systems and automation is a plus\nFamiliarity with Python or equivalent programming languages is a plus\nAbout Twist Bioscience\nTwist Bioscience synthesizes genes from scratch, known as “writing” DNA. Just as children learn to both read and write, the next phase of development for the genomics revolution is the ability to write DNA.\nAt Twist Bioscience, we work in service of people who are changing the world for the better. In fields such as health care, agriculture, industrial chemicals and data storage, our unique silicon-based DNA Synthesis Platform provides precision at a scale that is otherwise unavailable to our customers.\nTwist Bioscience Corporation is an Equal Opportunity Employer. Twist Bioscience Corporation provides equal employment opportunities to all employees and applicants for employment without regard to race, color, religion, sex, sexual orientation, gender identity, national origin, age, disability, genetic characteristics, or any other category protected by law.\nThe base cash compensation for this California-based role is below. In addition to base salary, this role is eligible for bonus, equity, and a generous benefits package. Final compensationamounts are determined by multiple factors, including candidate skill, experience, expertise, and location and may vary from the amount listed above. Compensationmay be different in other locations.\nSan Francisco Bay Area Pay Range\n$189,000—$224,000 USD","description_format":"text","description_chars":5241,"description_truncated":false,"requirements":{"experience_years_min":5,"management_years_min":null,"team_size_min":null,"manages_managers":false,"education":{"level":"phd","optional":false},"security_clearance":false,"languages":[]},"benefits":["Equity"],"hiring_locations":[],"hiring_excludes":[],"relocation_offered":false,"industries":["Biotechnology","Genomics & Genetic Testing","Synthetic Biology"],"lifecycle":[{"event":"open","at":"2026-09-25T20:03:00Z"}],"visa":[{"country":"US","licensed_sponsor":true,"adverts_offering_sponsorship_24m":0,"sanctioned_now":false,"evidence":"H-1B filings in 12 months: 15 · green card filings: 5","filings_12m":15,"filings_prev_12m":20,"green_card_filings_12m":5,"median_offered_wage_usd":133750,"route":null,"cap_exempt":false,"checked_at":"2026-11-11T07:38:50+00:00","sources":["US Department of Labor: LCA disclosure data (H-1B, H-1B1, E-3)","US Department of Labor: PERM disclosure data (green cards)"],"filings_for_role_12m":0}],"liveness":{"score":18,"band":"cold","label":"Long shot","p_open":1,"p_active":0.635,"p_room":0.28,"age_days":74,"expected_fill_days":37,"reasons":["conf:1","win:tail","crowd:"],"computed_at":"2026-11-11T05:49:22Z"},"pay":{"stated_usd_annual":224000,"is_top_pay":true},"html_url":"https://alion.io/job/twist-bioscience-sr-manager-protein-sciences","json_url":"https://alion.io/job/twist-bioscience-sr-manager-protein-sciences.json","meta":{"generated_at":"2026-11-11T20:01:38Z","cache_seconds":300,"methodology":"https://alion.io/methodology","terms":"https://alion.io/terms","contact":"https://alion.io/contact","api":"https://alion.io/developers","about":"Alion is a live layer of people, companies and AI agents: who they are, whether they are real and active right now, what they do and how to work with them, readable by people and by agents and paid per call.","catalog":"https://alion.io/catalog.json","usage":{"tier":"crawler_verified","counted_by":"address","units_charged":1,"used_today":39020,"day_limit":null,"remaining_today":null,"minute_limit":300,"resets_at":"2026-11-12T00:00:00Z"}},"offers":[{"id":"company.slices","title":"One company in depth, by slice","status":"live","price":{"credits":0.1,"usd":0.01,"plus_per_slice":{"credits":0.05,"usd":0.005}},"unit":"per company, plus each slice with data","note":"the employer in depth","call":{"mcp_tool":"get_company","arguments":{"id":1814479},"rest":"https://alion.io/mcp/rest/get_company?id=1814479"},"human":"https://alion.io/catalog?offer=company.slices&for=job%2Ftwist-bioscience-sr-manager-protein-sciences"},{"id":"market.stats","title":"A market slice: pay, demand and time to fill","status":"live","price":{"credits":2,"usd":0.2},"unit":"per slice","note":"pay, demand and time to fill for this role and place","call":{"mcp_tool":"market_stats"},"human":"https://alion.io/catalog?offer=market.stats&for=job%2Ftwist-bioscience-sr-manager-protein-sciences"},{"id":"job.search","title":"Open jobs by role, technology, place, pay and visa","status":"live","price":{"credits":0.1,"usd":0.01},"unit":"per posting in a list","note":"similar open postings","call":{"mcp_tool":"search_jobs"},"human":"https://alion.io/catalog?offer=job.search&for=job%2Ftwist-bioscience-sr-manager-protein-sciences"},{"id":"company.verify","title":"Is this company real and active right now","status":"pilot","price":null,"unit":"per company","request":{"url":"https://alion.io/catalog/request","method":"POST","body":"{\"offer\": \"company.verify\", \"for\": \"job/twist-bioscience-sr-manager-protein-sciences\", \"note\": \"what you need it for\"}"},"human":"https://alion.io/catalog?offer=company.verify&for=job%2Ftwist-bioscience-sr-manager-protein-sciences"}],"agent":{"mcp":"https://alion.io/mcp/jobs","mcp_open":"https://alion.io/mcp/open","next":[{"tool":"get_job","arguments":{"id":1259705}},{"tool":"search_jobs","arguments":{"company":"twistbioscience.com","detail":"compact"}},{"tool":"match_people","arguments":{"job_id":1259705},"note":"people open to offers who fit this vacancy"}],"note":"The same data through MCP tools: https://alion.io/mcp/open needs no sign-in (compact searches, postings, people); https://alion.io/mcp with an Alion account has everything. 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