{"id":2644965,"url":"https://alion.io/job/twist-bioscience-sr-staff-program-manager-mes-custom-software-development-transformation","title":"Sr Staff Program Manager, MES Custom Software Development Transformation","company":{"id":1814479,"name":"Twist Bioscience","domain":"twistbioscience.com","url":"https://alion.io/company/twistbioscience","size_band":null,"is_staffing_agency":false,"employer_type":"direct","is_intermediary":false,"listed_via":null,"ats_vendor":"Greenhouse","truth_index":{"grade":"B","score":75,"open_postings":7,"ghost_share":0,"stale_share":1,"repost_share":0,"time_to_fill_p50_days":31,"computed_at":"2026-10-19T05:45:15Z"}},"role":"Management","role_family":"Management","seniority":"staff","employment_type":null,"work_mode":"hybrid","remote_scope":null,"remote_scope_basis":null,"remote_working_hours":null,"hiring_geo_confidence":"structured","locations":["South San Francisco, United States"],"countries":["US"],"hiring_countries":[],"hiring_countries_total":0,"salary":{"min":233000,"max":271000,"currency":"USD","period":"year","gross":null,"usd_annual":271000},"salary_estimate":null,"experience_years_min":12,"visa_sponsorship":false,"relocation_package":false,"has_equity":false,"technologies":[{"name":"Agile","optional":false},{"name":"Scrum","optional":false}],"status":"live","first_seen_at":"2026-10-15T19:16:33Z","employer_posted_date":"2026-10-15","last_verified_at":"2026-10-19T05:23:36Z","board_verified":true,"closed_at":null,"days_open":3,"trust":{"level":"ok","repost_count":null,"flags":[],"days_open":3},"description":"Sr Staff Program Manager, MES Custom Software Development Transformation (Hybrid in South San Francisco, CA or Wilsonville, OR)\nSummary\nTwist Bioscience is embarking on a strategic transformation of its Manufacturing Execution System (MES) to modernize our technology platform, enable operational scalability, and support the evolving needs of our business. We are seeking an experienced Sr Staff Program Manager to drive the strategic planning, cross-functional coordination, and hands-on execution of this business-critical initiative. Reporting directly to the Sr Director of Technology Operations, this role will lead the delivery of the MES replatform efforts, bringing structure, Agile delivery discipline, and strong program governance to ensure successful execution. Partnering closely with Technology, Manufacturing Operations, R&D, Quality, and business stakeholders, this individual will be responsible for aligning priorities, managing complex dependencies, and driving decisions.\nKey Responsibilities\nStrategic Program Leadership: Lead the overall MES replatform transformation, translating strategic objective into an actionable, integrated program roadmap.\nMES Project Execution: Lead day-to-day execution of the MES replatform, managing timelines, scope, resources, and deliverable milestones.\nStakeholder Engagement: Partner closely with business users, IT process owners, and external software vendors/agencies to communicate status, align expectations, and resolve cross-functional issues.\nBudget & Resource Management: Track project expenditures, support financial budgeting, and ensure efficient resource allocation across core initiative tracks.\nProcess & Change Optimization: Implement company and departmental procedures that affect immediate operations. Assist with organizational change management to ensure smooth system adoption and transition from legacy platforms.\nRisk & Quality Management: Proactively identify technical, operational, and integration risks. Enforce quality-control practices, compliance standards, and validation protocols required in manufacturing software environments.\nQualifications\nEducation: Bachelor’s degree in Computer Science, Software Engineering, Industrial Engineering, Information Technology, or a related field. \nOverall experience: Minimum of 12 years of experience performing and improving business processes, with a strong focus on manufacturing, life sciences, engineering, or operations.\nAgile & Delivery Expertise: Proven expertise in Agile project delivery frameworks (Scrum Master, SAFe, or PMI-ACP certifications preferred) with a strong track record of facilitating Agile ceremonies and managing iteration cycles.\nProject Leadership: 5 plus years in project or program management leading cross-functional custom software development teams.\nSolid hands-on understanding of the custom software development lifecycle (SDLC), modern software architecture principles, and business transformation frameworks. Biotech or pharmaceutical industry experience is preferred.\nStrong leadership, negotiation, and conflict-resolution skills, with a track record of translating complex manufacturing requirements into actionable software solutions. \nPreferred Qualifications\nCertifications: Certified ScrumMaster (CSM), PMI-ACP, or SAFe Agilist.\nIndustry Focus: Specialized experience in biotech, pharmaceutical, semiconductor, or advanced discrete manufacturing environments.\nDomain Knowledge: Deep understanding of custom software development lifecycles (SDLC), shop-floor manufacturing processes, SCADA/PLC integration, and ISA-95 standards.\nAbout Twist Bioscience\nTwist Bioscience synthesizes genes from scratch, known as “writing” DNA. Just as children learn to both read and write, the next phase of development for the genomics revolution is the ability to write DNA.\nAt Twist Bioscience, we work in service of people who are changing the world for the better. In fields such as health care, agriculture, industrial chemicals and data storage, our unique silicon-based DNA Synthesis Platform provides precision at a scale that is otherwise unavailable to our customers.\nTwist Bioscience Corporation is an Equal Opportunity Employer. Twist Bioscience Corporation provides equal employment opportunities to all employees and applicants for employment without regard to race, color, religion, sex, sexual orientation, gender identity, national origin, age, disability, genetic characteristics, or any other category protected by law.\nThe base cash compensation for this California-based role is below. In addition to base salary, this role is eligible for bonus, equity, and a generous benefits package. Final compensationamounts are determined by multiple factors, including candidate skill, experience, expertise, and location and may vary from the amount listed above. Compensationmay be different in other locations.\nSan Francisco Bay Area Pay Range\n$233,000—$271,000 USD","description_format":"text","description_chars":4937,"description_truncated":false,"requirements":{"experience_years_min":12,"management_years_min":null,"team_size_min":null,"manages_managers":false,"education":{"level":"bachelor","optional":false},"security_clearance":false,"languages":[]},"benefits":["Equity"],"hiring_locations":[{"name":"United States","iso":"US","kind":"country"}],"hiring_excludes":[],"relocation_offered":false,"industries":["Biotechnology","Genomics & Genetic Testing","Synthetic Biology"],"lifecycle":[{"event":"open","at":"2026-10-15T19:50:57Z"}],"visa":[{"country":"US","licensed_sponsor":true,"evidence":"H-1B filings in 12 months: 15 · green card filings: 5","filings_12m":15,"filings_prev_12m":20,"green_card_filings_12m":5,"median_offered_wage_usd":133750,"route":null,"cap_exempt":false,"checked_at":"2026-10-15T11:24:14+00:00","sources":["US Department of Labor: LCA disclosure data (H-1B, H-1B1, E-3)","US Department of Labor: PERM disclosure data (green cards)"],"filings_for_role_12m":0}],"liveness":{"score":90,"band":"hot","label":"Hiring now","p_open":1,"p_active":0.903,"p_room":1,"age_days":3,"expected_fill_days":31,"reasons":["conf:0","velocity","win:early"],"computed_at":"2026-10-19T05:45:15Z"},"pay":{"stated_usd_annual":271000,"is_top_pay":true},"html_url":"https://alion.io/job/twist-bioscience-sr-staff-program-manager-mes-custom-software-development-transformation","json_url":"https://alion.io/job/twist-bioscience-sr-staff-program-manager-mes-custom-software-development-transformation.json","meta":{"generated_at":"2026-10-19T08:12:59Z","cache_seconds":300,"methodology":"https://alion.io/methodology","terms":"https://alion.io/terms","contact":"https://alion.io/contact","api":"https://alion.io/developers","about":"Alion is a live layer of people, companies and AI agents: who they are, whether they are real and active right now, what they do and how to work with them, readable by people and by agents and paid per call.","catalog":"https://alion.io/catalog.json","usage":{"tier":"crawler_verified","counted_by":"address","units_charged":1,"used_today":5330,"day_limit":null,"remaining_today":null,"minute_limit":300,"resets_at":"2026-10-20T00:00:00Z"}},"offers":[{"id":"company.slices","title":"One company in depth, by slice","status":"live","price":{"credits":0.02,"usd":0.002,"plus_per_slice":{"credits":0.05,"usd":0.005}},"unit":"per company, plus each slice with data","note":"the employer in depth","call":{"mcp_tool":"get_company","arguments":{"id":1814479},"rest":"https://alion.io/mcp/rest/get_company?id=1814479"},"human":"https://alion.io/catalog?offer=company.slices&for=job%2Ftwist-bioscience-sr-staff-program-manager-mes-custom-software-development-transformation"},{"id":"market.stats","title":"A market slice: pay, demand and time to fill","status":"live","price":{"credits":1,"usd":0.1},"unit":"per slice","note":"pay, demand and time to fill for this role and place","call":{"mcp_tool":"market_stats"},"human":"https://alion.io/catalog?offer=market.stats&for=job%2Ftwist-bioscience-sr-staff-program-manager-mes-custom-software-development-transformation"},{"id":"job.search","title":"Open jobs by role, technology, place, pay and visa","status":"live","price":{"credits":0.02,"usd":0.002},"unit":"per posting in a list","note":"similar open postings","call":{"mcp_tool":"search_jobs"},"human":"https://alion.io/catalog?offer=job.search&for=job%2Ftwist-bioscience-sr-staff-program-manager-mes-custom-software-development-transformation"},{"id":"company.verify","title":"Is this company real and active right now","status":"pilot","price":null,"unit":"per company","request":{"url":"https://alion.io/catalog/request","method":"POST","body":"{\"offer\": \"company.verify\", \"for\": \"job/twist-bioscience-sr-staff-program-manager-mes-custom-software-development-transformation\", \"note\": \"what you need it for\"}"},"human":"https://alion.io/catalog?offer=company.verify&for=job%2Ftwist-bioscience-sr-staff-program-manager-mes-custom-software-development-transformation"}]}