{"id":745866,"url":"https://alion.io/job/vaxcyte-engineer-ii-conjugation-development-and-manufacturing","title":"Engineer II, Conjugation Development and Manufacturing","company":{"id":685268,"name":"Vaxcyte","domain":"vaxcyte.com","url":"https://alion.io/company/vaxcyte","size_band":null,"is_staffing_agency":false,"employer_type":"direct","is_intermediary":false,"listed_via":null,"ats_vendor":"Greenhouse","truth_index":{"grade":"A","score":89,"open_postings":16,"ghost_share":0,"stale_share":0.25,"repost_share":0,"time_to_fill_p50_days":74,"computed_at":"2026-11-12T10:38:37Z"}},"role":"Industrial Engineering","role_family":"Industrial Engineering","seniority":"middle","employment_type":null,"work_mode":"on_site","remote_scope":null,"remote_scope_basis":null,"remote_working_hours":null,"hiring_geo_confidence":"structured","locations":["San Carlos, United States"],"countries":["US"],"hiring_countries":[],"hiring_countries_total":0,"salary":{"min":146000,"max":171000,"currency":"USD","period":"year","gross":null,"usd_annual":171000},"salary_estimate":null,"experience_years_min":10,"visa_sponsorship":false,"relocation_package":false,"has_equity":true,"technologies":[{"name":"GMP","optional":false},{"name":"JMP","optional":false}],"status":"live","first_seen_at":"2026-06-12T15:30:18Z","employer_posted_date":"2026-09-18","last_verified_at":"2026-11-12T11:23:57Z","board_verified":true,"closed_at":null,"days_open":153,"trust":{"level":"ok","repost_count":0,"flags":[],"days_open":152},"description":"Join our Mission to Protect Humankind!\nVaxcyte is a clinical-stage vaccine innovation company engineering high-fidelity vaccines to protect humankind from the consequences of bacterial diseases, which have serious and costly health consequences when left unchecked. Working to eradicate or treat bacterial infections such as invasive pneumococcal disease, Group A Strep, and Shigella is just the beginning. Our path to success is clear and well-defined, and Vaxcyte is set up to go the distance. \nWHAT we do is every bit as important as HOW we do it! Our work together is guided by four enduring core values:\n*RETHINK CONVENTION: We bring creative and intellectual diversity to every facet of the work we do in order to innovate and re-innovate the way vaccines are delivered.\n*AIM HIGH: We embody our collectively audacious goal to courageously make the most complex biologics ever attempted to protect humankind.\n*LEAD WITH HEART: Everyone leads at Vaxcyte with a kindness-first, inclusive approach to collaboration and vigorous debate that advances our business objectives.\n*MODEL EXCELLENCE: The magnitude of our challenge requires our shared commitment to demonstrating integrity, accountability, equality and clarity across communications and decision making.\nSummary:\nVaxcyte is seeking a highly motivated and technically proficient Engineer II to join the Conjugation Process Development and Manufacturing group within the CMC organization. This individual will contribute to the development, scale up, and manufacturing of Vaxcyte’s multi valent polysaccharide based conjugate vaccines, which leverage a novel carrier protein produced through cell free synthesis. Conjugation-the covalent linkage of polysaccharide antigens to carrier proteins-is a critical component of Vaxcyte’s vaccine platform, and this role will support both laboratory development and cGMP manufacturing activities.\nThe successful candidate will bring hands on laboratory experience, a solid understanding of bioprocess operations, and practical exposure to cGMP environments, ideally within late-stage development. This position requires close collaboration with cross functional CMC teams, active participation in production campaigns, and the ability to independently execute development experiments and document technical findings. The role offers a unique opportunity to contribute directly to the advancement of Vaxcyte’s vaccine programs while developing deep expertise in conjugation process development and manufacturing.\nEssential Functions:\nOperation and maintenance of laboratory equipment, including chemical reactors, TFF systems, HPLCs, and plate readers.\nSupport the design and execution of development studies to optimize and characterize conjugation processes.\nProvide technical oversight during cGMP production campaigns, including preparation, on floor support, troubleshooting, deviation assessment, and change control execution.\nReview executed protocols and batch records for accuracy, completeness, and compliance.\nServe as a subject matter expert for conjugation related activities on project teams.\nContribute to facility and equipment design considerations to support process scale up and manufacturing readiness.\nParticipate in the development of conjugation processes for pipeline programs.\nMaintain accurate and complete documentation in laboratory notebooks or electronic systems.\nEngage in technical discussions and contribute to data interpretation and decision making.\nCollaborate effectively within a team environment to support departmental and program objectives.\nRequirements: \nPhD with 2-5, MS with minimum of 7, BS/BA with minimum of 10 years of experience in Chemical Engineering, Biochemical Engineering, Chemistry, Biology, or a related discipline\nPractical experience with bioprocess operations at bench, pilot, or manufacturing scale.\nStrong working knowledge of cGMP principles and their application in bioprocess environments.\nFoundational understanding of engineering principles relevant to bioprocess development and scale up.\nProficiency with standard software tools, including Excel, Word, PowerPoint, Visio, and JMP.\nDemonstrated ability to work in cross functional teams and manage multiple concurrent activities.\nExcellent written and verbal communication skills.\nReports to: Staff Engineer, Conjugation Development and Manufacturing\nLocation: San Carlos, CA\nWork Arrangement: Onsite 5 days per week\nCompensation:\nThe compensation package will be competitive and includes comprehensive benefits and an equity component.\nSalary Range: $146,000 - $171,000 (SF Bay Area). Salary ranges for non-California locations may vary.\nEqual Opportunity\nWe are an equal opportunity employer. All qualified applicants will receive consideration for employment without regard to race, color, religion, sex, sexual orientation, gender identity, national origin, disability or veteran status.\nRecruitment Fraud Notice\nPlease be aware of fraud or scams from individuals, organizations and/or internet sites claiming to represent Vaxcyte in recruitment activities. Vaxcyte has an established recruitment process for all positions prior to issuing an offer for employment and we will never extend unsolicited employment offers or ask candidates to provide financial or sensitive personal information as part of the application process. All legitimate communication from Vaxcyte will come from an official @vaxcyte.com email address. Qualified and interested candidates should apply to current openings at vaxcyte.com/careers.","description_format":"text","description_chars":5540,"description_truncated":false,"requirements":{"experience_years_min":10,"management_years_min":null,"team_size_min":null,"manages_managers":false,"education":{"level":"phd","optional":false},"security_clearance":false,"languages":[]},"benefits":["Equity"],"hiring_locations":[],"hiring_excludes":[],"relocation_offered":false,"industries":["Vaccines"],"lifecycle":[{"event":"open","at":"2026-09-11T14:11:25Z"}],"visa":[{"country":"US","licensed_sponsor":true,"adverts_offering_sponsorship_24m":0,"sanctioned_now":false,"evidence":"H-1B filings in 12 months: 9 · green card filings: 2","filings_12m":9,"filings_prev_12m":11,"green_card_filings_12m":2,"median_offered_wage_usd":172955,"route":null,"cap_exempt":false,"checked_at":"2026-11-12T07:36:15+00:00","sources":["US Department of Labor: LCA disclosure data (H-1B, H-1B1, E-3)","US Department of Labor: PERM disclosure data (green cards)"],"filings_for_role_12m":0}],"liveness":{"score":16,"band":"cold","label":"Long shot","p_open":1,"p_active":0.584,"p_room":0.28,"age_days":152,"expected_fill_days":74,"reasons":["conf:4","win:tail","crowd:"],"computed_at":"2026-11-12T10:38:37Z"},"pay":{"stated_usd_annual":171000,"is_top_pay":true},"html_url":"https://alion.io/job/vaxcyte-engineer-ii-conjugation-development-and-manufacturing","json_url":"https://alion.io/job/vaxcyte-engineer-ii-conjugation-development-and-manufacturing.json","meta":{"generated_at":"2026-11-12T16:41:21Z","cache_seconds":300,"methodology":"https://alion.io/methodology","terms":"https://alion.io/terms","contact":"https://alion.io/contact","api":"https://alion.io/developers","about":"Alion is a live layer of people, companies and AI agents: who they are, whether they are real and active right now, what they do and how to work with them, readable by people and by agents and paid per call.","catalog":"https://alion.io/catalog.json","usage":{"tier":"crawler_verified","counted_by":"address","units_charged":1,"used_today":35019,"day_limit":null,"remaining_today":null,"minute_limit":300,"resets_at":"2026-11-13T00:00:00Z"}},"offers":[{"id":"company.slices","title":"One company in depth, by slice","status":"live","price":{"credits":0.1,"usd":0.01,"plus_per_slice":{"credits":0.05,"usd":0.005}},"unit":"per company, plus each slice with data","note":"the employer in depth","call":{"mcp_tool":"get_company","arguments":{"id":685268},"rest":"https://alion.io/mcp/rest/get_company?id=685268"},"human":"https://alion.io/catalog?offer=company.slices&for=job%2Fvaxcyte-engineer-ii-conjugation-development-and-manufacturing"},{"id":"market.stats","title":"A market slice: pay, demand and time to fill","status":"live","price":{"credits":2,"usd":0.2},"unit":"per slice","note":"pay, demand and time to fill for this role and place","call":{"mcp_tool":"market_stats"},"human":"https://alion.io/catalog?offer=market.stats&for=job%2Fvaxcyte-engineer-ii-conjugation-development-and-manufacturing"},{"id":"job.search","title":"Open jobs by role, technology, place, pay and visa","status":"live","price":{"credits":0.1,"usd":0.01},"unit":"per posting in a list","note":"similar open postings","call":{"mcp_tool":"search_jobs"},"human":"https://alion.io/catalog?offer=job.search&for=job%2Fvaxcyte-engineer-ii-conjugation-development-and-manufacturing"},{"id":"company.verify","title":"Is this company real and active right now","status":"pilot","price":null,"unit":"per company","request":{"url":"https://alion.io/catalog/request","method":"POST","body":"{\"offer\": \"company.verify\", \"for\": \"job/vaxcyte-engineer-ii-conjugation-development-and-manufacturing\", \"note\": \"what you need it for\"}"},"human":"https://alion.io/catalog?offer=company.verify&for=job%2Fvaxcyte-engineer-ii-conjugation-development-and-manufacturing"}],"agent":{"mcp":"https://alion.io/mcp/jobs","mcp_open":"https://alion.io/mcp/open","next":[{"tool":"get_job","arguments":{"id":745866}},{"tool":"search_jobs","arguments":{"company":"vaxcyte.com","detail":"compact"}},{"tool":"match_people","arguments":{"job_id":745866},"note":"people open to offers who fit this vacancy"}],"note":"The same data through MCP tools: https://alion.io/mcp/open needs no sign-in (compact searches, postings, people); https://alion.io/mcp with an Alion account has everything. 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