{"id":745865,"url":"https://alion.io/job/vaxcyte-scientist-ii-conjugation-development","title":"Scientist II, Conjugation Development","company":{"id":685268,"name":"Vaxcyte","domain":"vaxcyte.com","url":"https://alion.io/company/vaxcyte","size_band":"501-1000","is_staffing_agency":false,"employer_type":"direct","is_intermediary":false,"listed_via":null,"ats_vendor":"Greenhouse","truth_index":{"grade":"A","score":93,"open_postings":40,"ghost_share":0,"stale_share":0.1,"repost_share":0,"time_to_fill_p50_days":78,"computed_at":"2026-10-15T05:46:00Z"}},"role":"Science & Research","role_family":"Science & Research","seniority":"middle","employment_type":null,"work_mode":"on_site","remote_scope":null,"remote_scope_basis":null,"remote_working_hours":null,"hiring_geo_confidence":"structured","locations":["San Carlos, United States"],"countries":["US"],"hiring_countries":[],"hiring_countries_total":0,"salary":{"min":146000,"max":171000,"currency":"USD","period":"year","gross":null,"usd_annual":171000},"salary_estimate":null,"experience_years_min":10,"visa_sponsorship":false,"relocation_package":false,"has_equity":true,"technologies":[],"status":"live","first_seen_at":"2026-06-18T17:43:09Z","employer_posted_date":"2026-10-09","last_verified_at":"2026-10-15T14:54:42Z","board_verified":true,"closed_at":null,"days_open":118,"trust":{"level":"ok","repost_count":0,"flags":[],"days_open":118},"description":"Join our Mission to Protect Humankind!\nVaxcyte is a clinical-stage vaccine innovation company engineering high-fidelity vaccines to protect humankind from the consequences of bacterial diseases, which have serious and costly health consequences when left unchecked. Working to eradicate or treat bacterial infections such as invasive pneumococcal disease, Group A Strep, and Shigella is just the beginning. Our path to success is clear and well-defined, and Vaxcyte is set up to go the distance. \nWHAT we do is every bit as important as HOW we do it! Our work together is guided by four enduring core values:\n*RETHINK CONVENTION: We bring creative and intellectual diversity to every facet of the work we do in order to innovate and re-innovate the way vaccines are delivered.\n*AIM HIGH: We embody our collectively audacious goal to courageously make the most complex biologics ever attempted to protect humankind.\n*LEAD WITH HEART: Everyone leads at Vaxcyte with a kindness-first, inclusive approach to collaboration and vigorous debate that advances our business objectives.\n*MODEL EXCELLENCE: The magnitude of our challenge requires our shared commitment to demonstrating integrity, accountability, equality and clarity across communications and decision making.\nSummary:\nVaxcyte is looking for a Scientist II, Conjugation Development. The candidate’s primary responsibility will be to lead and execute experimental activities that support company’s pneumococcal conjugate vaccine program with a focus on developing a deeper understanding of the conjugation process. In parallel, the candidate will work on conjugation process development for Vaxcyte’s pipeline programs contributing to process optimization, scalability, and technical readiness for future clinical manufacturing. Specifically, this will include preparation, purification, and analytical characterization of chemically modified polysaccharides and polysaccharide-protein conjugates. The ideal candidate will have significant laboratory experience and an excellent understanding of analytical chemistry principles. The successful candidate will be expected to design, execute, and troubleshoot experiments with minimal guidance. The candidate will also contribute when needed to a range of related areas such as analytical development and stability studies. Responsibilities will additionally include record management, data presentation at group meetings, authorship of laboratory protocols and development reports, communication with external organizations during tech transfer, and actively contributing to collaborative studies with other members of the conjugation group.\nEssential Functions:\nOptimize and troubleshoot multi-step syntheses of protein-polysaccharide conjugates.\nPurify polysaccharides and conjugates using a variety of methods including dialysis, size-exclusion chromatography, and tangential flow filtration (TFF).\nAnalyze polysaccharides and conjugates with a variety of analytical methods. Develop new laboratory workflows and analyses beyond established procedures when appropriate.\nAdvise team members on experimental design, interpretation of results, and troubleshooting.\nModel and train team members on best practices for adherence to protocols and data management.\nServe as a subject matter expert during tech transfer of conjugation processes to contract manufacturing organizations.\nMaintain highly organized records to enable optimization and assessment of reproducibility.\nAttend team meetings ready to provide updates on conjugation development progress.\nRequirements: \nPhD in chemistry, biochemistry, or related field with minimum 2-5 years of industry experience, or combination of industry and postdoctoral research; MS with minimum 7 years industry experience, or BS with minimum 10 years of industry experience.\nStrong biochemistry and organic chemistry knowledge base underpinning several years’ experience preparing bioconjugates.\nProficiency with small- and large-scale techniques for purification of bioconjugates, including tangential flow filtration.\nProficiency in a variety of techniques for bioconjugate analysis such as colorimetric assays, HPLC, and SEC-MALS.\nSufficient knowledge of analytical principles to develop fit-for-purpose analytical methods as needed and provide cross-functional feedback on draft analytical methods.\nExperience with Design of Experiments is desirable.\nExperience with chemical modification of polysaccharides is desirable.\nExperience implementing and/or using electronic notebooks is desirable.\nAttention to detail and excellent organizational skills.\nStrong interpersonal skills; ability to communicate effectively both verbally and in written formats.\nSelf-starter; ability to work in a fast-paced, cross-functional environment and collaborate effectively with other team members.\nEnthusiasm to learn the new skills and techniques necessary to tackle problems outside of current area of expertise.\nReports to: Associate Director, Conjugation Development\nLocation: San Carlos, CA\nWork Arrangement: Onsite 5 days per week\nCompensation:\nThe compensation package will be competitive and includes comprehensive benefits and an equity component.\nSalary Range: $146,000 - $171,000\nEqual Opportunity\nWe are an equal opportunity employer. All qualified applicants will receive consideration for employment without regard to race, color, religion, sex, sexual orientation, gender identity, national origin, disability or veteran status.\nRecruitment Fraud Notice\nPlease be aware of fraud or scams from individuals, organizations and/or internet sites claiming to represent Vaxcyte in recruitment activities. Vaxcyte has an established recruitment process for all positions prior to issuing an offer for employment and we will never extend unsolicited employment offers or ask candidates to provide financial or sensitive personal information as part of the application process. All legitimate communication from Vaxcyte will come from an official @vaxcyte.com email address. Qualified and interested candidates should apply to current openings at vaxcyte.com/careers.","description_format":"text","description_chars":6107,"description_truncated":false,"requirements":{"experience_years_min":10,"management_years_min":null,"team_size_min":null,"manages_managers":false,"education":{"level":"phd","optional":false},"security_clearance":false,"languages":[]},"benefits":["Equity"],"hiring_locations":[],"hiring_excludes":[],"relocation_offered":false,"industries":["Vaccines"],"lifecycle":[{"event":"open","at":"2026-09-11T14:11:25Z"}],"visa":[{"country":"US","licensed_sponsor":true,"evidence":"H-1B filings in 12 months: 9 · green card filings: 2","filings_12m":9,"filings_prev_12m":11,"green_card_filings_12m":2,"median_offered_wage_usd":172955,"route":null,"cap_exempt":false,"checked_at":"2026-10-15T11:24:14+00:00","sources":["US Department of Labor: LCA disclosure data (H-1B, H-1B1, E-3)","US Department of Labor: PERM disclosure data (green cards)"],"filings_for_role_12m":0}],"liveness":{"score":23,"band":"cold","label":"Long shot","p_open":1,"p_active":0.651,"p_room":0.36,"age_days":118,"expected_fill_days":78,"reasons":["conf:2","win:tail","crowd:"],"computed_at":"2026-10-15T05:46:00Z"},"pay":{"stated_usd_annual":171000,"is_top_pay":true},"html_url":"https://alion.io/job/vaxcyte-scientist-ii-conjugation-development","json_url":"https://alion.io/job/vaxcyte-scientist-ii-conjugation-development.json","meta":{"generated_at":"2026-10-15T15:31:32Z","cache_seconds":300,"methodology":"https://alion.io/methodology","terms":"https://alion.io/terms","contact":"https://alion.io/contact","api":"https://alion.io/developers","about":"Alion is a live layer of people, companies and AI agents: who they are, whether they are real and active right now, what they do and how to work with them, readable by people and by agents and paid per call.","catalog":"https://alion.io/catalog.json","usage":{"tier":"crawler_verified","counted_by":"address","units_charged":1,"used_today":23799,"day_limit":null,"remaining_today":null,"minute_limit":300,"resets_at":"2026-10-16T00:00:00Z"}},"offers":[{"id":"company.slices","title":"One company in depth, by slice","status":"live","price":{"credits":0.02,"usd":0.002,"plus_per_slice":{"credits":0.05,"usd":0.005}},"unit":"per company, plus each slice with data","note":"the employer in depth","call":{"mcp_tool":"get_company","arguments":{"id":685268},"rest":"https://alion.io/mcp/rest/get_company?id=685268"},"human":"https://alion.io/catalog?offer=company.slices&for=job%2Fvaxcyte-scientist-ii-conjugation-development"},{"id":"market.stats","title":"A market slice: pay, demand and time to fill","status":"live","price":{"credits":1,"usd":0.1},"unit":"per slice","note":"pay, demand and time to fill for this role and place","call":{"mcp_tool":"market_stats"},"human":"https://alion.io/catalog?offer=market.stats&for=job%2Fvaxcyte-scientist-ii-conjugation-development"},{"id":"job.search","title":"Open jobs by role, technology, place, pay and visa","status":"live","price":{"credits":0.02,"usd":0.002},"unit":"per posting in a list","note":"similar open postings","call":{"mcp_tool":"search_jobs"},"human":"https://alion.io/catalog?offer=job.search&for=job%2Fvaxcyte-scientist-ii-conjugation-development"},{"id":"company.verify","title":"Is this company real and active right now","status":"pilot","price":null,"unit":"per company","request":{"url":"https://alion.io/catalog/request","method":"POST","body":"{\"offer\": \"company.verify\", \"for\": \"job/vaxcyte-scientist-ii-conjugation-development\", \"note\": \"what you need it for\"}"},"human":"https://alion.io/catalog?offer=company.verify&for=job%2Fvaxcyte-scientist-ii-conjugation-development"}]}