{"id":4116936,"url":"https://alion.io/job/vaxcyte-senior-engineer-conjugation-development","title":"Senior Engineer, Conjugation Development","company":{"id":685268,"name":"Vaxcyte","domain":"vaxcyte.com","url":"https://alion.io/company/vaxcyte","size_band":null,"is_staffing_agency":false,"employer_type":"direct","is_intermediary":false,"listed_via":null,"ats_vendor":"Greenhouse","truth_index":{"grade":"A","score":89,"open_postings":17,"ghost_share":0,"stale_share":0.235,"repost_share":0,"time_to_fill_p50_days":73,"computed_at":"2026-11-11T05:49:22Z"}},"role":"Industrial Engineering","role_family":"Industrial Engineering","seniority":"senior","employment_type":null,"work_mode":"on_site","remote_scope":null,"remote_scope_basis":null,"remote_working_hours":null,"hiring_geo_confidence":"structured","locations":["San Carlos, United States"],"countries":["US"],"hiring_countries":[],"hiring_countries_total":0,"salary":{"min":170000,"max":198000,"currency":"USD","period":"year","gross":null,"usd_annual":198000},"salary_estimate":null,"experience_years_min":10,"visa_sponsorship":false,"relocation_package":false,"has_equity":true,"technologies":[{"name":"Design of Experiments","optional":false},{"name":"FMEA","optional":false},{"name":"GMP","optional":false}],"status":"live","first_seen_at":"2026-11-11T23:09:01Z","employer_posted_date":"2026-11-11","last_verified_at":"2026-11-12T00:19:21Z","board_verified":true,"closed_at":null,"days_open":0,"trust":{"level":"ok","repost_count":null,"flags":[],"days_open":0},"description":"Join our Mission to Protect Humankind!\nVaxcyte is a clinical-stage vaccine innovation company engineering high-fidelity vaccines to protect humankind from the consequences of bacterial diseases, which have serious and costly health consequences when left unchecked. Working to eradicate or treat bacterial infections such as invasive pneumococcal disease, Group A Strep, and Shigella is just the beginning. Our path to success is clear and well-defined, and Vaxcyte is set up to go the distance. \nWHAT we do is every bit as important as HOW we do it! Our work together is guided by four enduring core values:\n*RETHINK CONVENTION: We bring creative and intellectual diversity to every facet of the work we do in order to innovate and re-innovate the way vaccines are delivered.\n*AIM HIGH: We embody our collectively audacious goal to courageously make the most complex biologics ever attempted to protect humankind.\n*LEAD WITH HEART: Everyone leads at Vaxcyte with a kindness-first, inclusive approach to collaboration and vigorous debate that advances our business objectives.\n*MODEL EXCELLENCE: The magnitude of our challenge requires our shared commitment to demonstrating integrity, accountability, equality and clarity across communications and decision making.\nSummary:\nThe Development organization is comprised of four Process teams: Protein, Polysaccharide, Conjugate Drug Substance (Conjugation), and Drug Product. These Process Development teams are supported by Analytical Development and Formulation Development teams. Vaxcyte is looking for a Sr. Engineer with experience in campaign support, tech transfer, and GMP/regulatory authoring to join the Conjugation engineering team. The candidate will manage the TFF and dead end filtration operations of our CMO partners, transfer new conjugation processes from the San Carlos labs to a CDMO, and generate documentation supporting our regulatory filings.\nEssential Functions: \nLead all pre-commercial CDMO TFF and filtration operations across our conjugation network, and provide technical support to our commercial operation partners\nContribute to CMO manufacturing preparation and oversight via document authoring, document review, person in plant responsibilities, and troubleshooting when necessary\nDevelop data analytics platforms to trend and summarize GMP and Commercial process performance, enabling both process optimization as well as Continued Process Verification\nSupport scale-up activities and tech transfer of early phase clinical candidates to an external CMO\nFacilitate cross-functional process risk analysis using appropriate tools such as FMEA\nPresent/communicate data to the Conjugation Development team as well as broader CMC team\nCollate data and author supplementary documents for BLA, CPV, and other regulatory interactions\nServe as a guide and mentor to junior team members\nRequirements: \nPhD in Chemical/Biochemical Engineering or similar, with 2+ years of industry experience; MS with 5+ years of industry experience; or BS with 10+ years of industry experience\nBoth practical experience with and theoretical knowledge of engineering principles involved in scaling processes from development lab to pilot / manufacturing plant\nWorking knowledge of the requirements of GMP manufacturing, preferably with hands on GMP experience through either a Manufacturing or MSAT role\nExperience working with CMOs highly desired; ability to effectively transfer processes to CMO, and to oversee development and manufacturing activities performed at CMO; ability to travel to CMO (some international travel required) to perform person-in-plant oversight activities\nSolid understanding of the principals of DoE (Design of Experiments)\nExperience with late-stage process development activities such as risk assessments (e.g., FMEA) and identification of CPPs and CQAs is a plus\nExperience writing IND, BLA, or CPV sections is a plus\nGeneral regulatory experience is a plus\nExpertise in tangential flow filtration (TFF) and dead end filtrations\nBioconjugate or protein purification knowledge and experience, process scaling and optimization, and reactor scale up is a plus\nDemonstrated success working in a cross-functional team environment on multiple projects; ability to work both on a team (as member and/or leader) and independently to deliver results\nStrong interpersonal skills, with excellent written and verbal communication skills\nReports to: Associate Director, Conjugation Development\nLocation: San Carlos, CA\nWork Arrangement (may be adjusted based on business needs, job responsibilities, or changes to company policy): Onsite (minimum of 4 days per week onsite)\nCompensation: The compensation package will be competitive and includes comprehensive benefits and an equity component.\nSalary Range: $170,000 - $198,000 (SF Bay Area). Salary ranges for non-California locations may vary.\nEqual Opportunity\nWe are an equal opportunity employer. All qualified applicants will receive consideration for employment without regard to race, color, religion, sex, sexual orientation, gender identity, national origin, disability or veteran status.\nRecruitment Fraud Notice\nPlease be aware of fraud or scams from individuals, organizations and/or internet sites claiming to represent Vaxcyte in recruitment activities. Vaxcyte has an established recruitment process for all positions prior to issuing an offer for employment and we will never extend unsolicited employment offers or ask candidates to provide financial or sensitive personal information as part of the application process. All legitimate communication from Vaxcyte will come from an official @vaxcyte.com email address. Qualified and interested candidates should apply to current openings at vaxcyte.com/careers.","description_format":"text","description_chars":5749,"description_truncated":false,"requirements":{"experience_years_min":10,"management_years_min":null,"team_size_min":null,"manages_managers":false,"education":{"level":"phd","optional":false},"security_clearance":false,"languages":[]},"benefits":["Equity"],"hiring_locations":[],"hiring_excludes":[],"relocation_offered":false,"industries":["Vaccines"],"lifecycle":[{"event":"open","at":"2026-11-12T00:19:21Z"}],"visa":[{"country":"US","licensed_sponsor":true,"adverts_offering_sponsorship_24m":0,"sanctioned_now":false,"evidence":"H-1B filings in 12 months: 9 · green card filings: 2","filings_12m":9,"filings_prev_12m":11,"green_card_filings_12m":2,"median_offered_wage_usd":172955,"route":null,"cap_exempt":false,"checked_at":"2026-11-11T07:38:50+00:00","sources":["US Department of Labor: LCA disclosure data (H-1B, H-1B1, E-3)","US Department of Labor: PERM disclosure data (green cards)"],"filings_for_role_12m":0}],"liveness":{"score":86,"band":"hot","label":"Hiring now","p_open":1,"p_active":0.86,"p_room":1,"age_days":0,"expected_fill_days":73,"reasons":["conf:1","win:early"],"computed_at":"2026-11-12T01:23:41Z"},"pay":{"stated_usd_annual":198000,"is_top_pay":true},"html_url":"https://alion.io/job/vaxcyte-senior-engineer-conjugation-development","json_url":"https://alion.io/job/vaxcyte-senior-engineer-conjugation-development.json","meta":{"generated_at":"2026-11-12T01:23:41Z","cache_seconds":300,"methodology":"https://alion.io/methodology","terms":"https://alion.io/terms","contact":"https://alion.io/contact","api":"https://alion.io/developers","about":"Alion is a live layer of people, companies and AI agents: who they are, whether they are real and active right now, what they do and how to work with them, readable by people and by agents and paid per call.","catalog":"https://alion.io/catalog.json","usage":{"tier":"crawler_verified","counted_by":"address","units_charged":1,"used_today":3289,"day_limit":null,"remaining_today":null,"minute_limit":300,"resets_at":"2026-11-13T00:00:00Z"}},"offers":[{"id":"company.slices","title":"One company in depth, by slice","status":"live","price":{"credits":0.1,"usd":0.01,"plus_per_slice":{"credits":0.05,"usd":0.005}},"unit":"per company, plus each slice with data","note":"the employer in depth","call":{"mcp_tool":"get_company","arguments":{"id":685268},"rest":"https://alion.io/mcp/rest/get_company?id=685268"},"human":"https://alion.io/catalog?offer=company.slices&for=job%2Fvaxcyte-senior-engineer-conjugation-development"},{"id":"market.stats","title":"A market slice: pay, demand and time to fill","status":"live","price":{"credits":2,"usd":0.2},"unit":"per slice","note":"pay, demand and time to fill for this role and place","call":{"mcp_tool":"market_stats"},"human":"https://alion.io/catalog?offer=market.stats&for=job%2Fvaxcyte-senior-engineer-conjugation-development"},{"id":"job.search","title":"Open jobs by role, technology, place, pay and visa","status":"live","price":{"credits":0.1,"usd":0.01},"unit":"per posting in a list","note":"similar open postings","call":{"mcp_tool":"search_jobs"},"human":"https://alion.io/catalog?offer=job.search&for=job%2Fvaxcyte-senior-engineer-conjugation-development"},{"id":"company.verify","title":"Is this company real and active right now","status":"pilot","price":null,"unit":"per company","request":{"url":"https://alion.io/catalog/request","method":"POST","body":"{\"offer\": \"company.verify\", \"for\": \"job/vaxcyte-senior-engineer-conjugation-development\", \"note\": \"what you need it for\"}"},"human":"https://alion.io/catalog?offer=company.verify&for=job%2Fvaxcyte-senior-engineer-conjugation-development"}],"agent":{"mcp":"https://alion.io/mcp/jobs","mcp_open":"https://alion.io/mcp/open","next":[{"tool":"get_job","arguments":{"id":4116936}},{"tool":"search_jobs","arguments":{"company":"vaxcyte.com","detail":"compact"}},{"tool":"match_people","arguments":{"job_id":4116936},"note":"people open to offers who fit this vacancy"}],"note":"The same data through MCP tools: https://alion.io/mcp/open needs no sign-in (compact searches, postings, people); https://alion.io/mcp with an Alion account has everything. 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