{"id":3303794,"url":"https://alion.io/job/vertex-pharmaceuticals-analytical-development-research-scientist-2","title":"Analytical Development Research Scientist","company":{"id":5871,"name":"Vertex Pharmaceuticals","domain":"vrtx.com","url":"https://alion.io/company/vrtx","size_band":"5000+","is_staffing_agency":false,"employer_type":"direct","is_intermediary":false,"listed_via":null,"ats_vendor":"Workday","truth_index":{"grade":"A","score":89,"open_postings":27,"ghost_share":0,"stale_share":0.444,"repost_share":0,"time_to_fill_p50_days":36,"computed_at":"2026-10-29T05:49:05Z"}},"role":"Science & Research","role_family":"Science & Research","seniority":"senior","employment_type":"full_time","work_mode":"on_site","remote_scope":null,"remote_scope_basis":null,"remote_working_hours":null,"hiring_geo_confidence":"structured","locations":["Boston, United States"],"countries":["US"],"hiring_countries":[],"hiring_countries_total":0,"salary":{"min":102800,"max":154200,"currency":"USD","period":"year","gross":null,"usd_annual":154200},"salary_estimate":null,"experience_years_min":6,"visa_sponsorship":false,"relocation_package":false,"has_equity":true,"technologies":[{"name":"ELISA","optional":false},{"name":"Flow Cytometry","optional":false},{"name":"GraphPad Prism","optional":false},{"name":"JMP","optional":false},{"name":"qPCR","optional":false}],"status":"live","first_seen_at":"2026-10-26T00:00:00Z","employer_posted_date":"2026-10-26","last_verified_at":"2026-10-29T06:55:36Z","board_verified":true,"closed_at":null,"days_open":3,"trust":{"level":"ok","repost_count":null,"flags":[],"days_open":3},"description":"Job Description\nGeneral Summary:\nVertex is seeking a highly motivated Scientist to join the Analytical Development team. This role will lead the development of analytical cell lines that serve as critical reagents for potency assay development, functional characterization, and analytical control strategy. The Scientist will play a critical role in the development, optimization, and validation of bioassays to support characterization of biologics and other complex biologic modalities. Operating at the interface between Research and Analytical Development, the Scientist will translate product mechanism of action into scientifically sound, phase-appropriate cell line and assay strategies. This role requires a strong background in bioassay development, biologics, and cell line development, as well as a passion for innovation and collaboration in a fast-paced, dynamic environment. The position will be based in Boston, MA.\nKey Duties and Responsibilities:\nCell Line Development:\nLead the design, characterization and lifecycle management of stable mammalian analytical cell lines expressing targets of interest, receptor systems, or reporter constructs to support potency and functional bioassays.\nManage CROs for the development of cell lines for use in bioassays. Act as the primary point of contact to provide technical guidance and ensure alignment with project goals and timelines. Troubleshoot and resolve technical challenges related to cell line development and maintenance.\nTranslate product mechanism of action into cell line designs and cell-based assay concepts aligned with potency and analytical control strategy.\nBioassay Development, Validation and Transfer:\nDevelop and support cell-based bioassays, including reporter gene assays, signaling pathway assays, proliferation or cytotoxicity assays, and other mechanism-based functional readouts.\nContribute to early-stage potency assay development and ensure effective technical continuity with late-stage potency, validation, transfer, and QC implementation strategies.\nEvaluate assay and cell line performance attributes, including sensitivity, specificity, robustness, stability, reproducibility, and fitness for intended use.\nLead or contribute to technical transfers to internal laboratories, external partners, vendors, or quality control functions, providing the technical rationale and knowledge needed for transfer.\nData Analysis and Interpretation:\nIndependently design and execute complex experimental plans, interpret data, identify technical risks, and recommend scientifically justified solutions.\nAuthor and review technical reports, protocols, method documents, cell line characterization packages, technology transfer documents, and CMC source documentation supporting regulatory submissions.\nEnsure that analytical cell line generation, assay development, documentation, and data packages are aligned with applicable quality and compliance expectations, good documentation practices, and data integrity principles.\nCollaboration and Cross-Functional Support:\nRepresent Analytical Development on cross-functional program teams and provide technical input on potency strategy, functional characterization, cell line suitability, and control strategy.\nMentor associates through technical guidance, experimental design review, data interpretation, and development of scientific judgment.\nInnovation and Continuous Improvement:\nIdentify opportunities to improve workflows, increase assay robustness and reduce development timelines.\nKnowledge and Skills:\nTechnical Skills:\nProven proficiency in plate-based assays including ELISA, reporter gene assays, cytotoxicity/ADCC/CDC assays and other bioassay readout.\nExperience with technologies such as flow cytometry, qPCR or ddPCR is preferred.\nFamiliarity with statistical tools and data analysis software (e.g., JMP, GraphPad Prism, SoftMax Pro and other bioassay data analysis software).\nKnowledge of USP, FDA and ICH guidelines governing bioassay development and validation.\nSoft Skills:\nAbility to multi-task as necessary, manage competing priorities and advance multiple projects within required timelines.\nStrong problem-solving and critical-thinking abilities. Attention to details.\nExcellent written and verbal communication skills with the ability to present complex data to diverse audiences.\nDemonstrated ability to work collaboratively.\nEffective delivery of objectives within the preset timeline.\nOpenness to using digital, automation, and AI-enabled tools to improve data analysis, documentation, knowledge management, and scientific workflows.\nEducation and Experience:\nPh.D. in Cell Biology, Molecular Biology, Biochemistry, Immunology, or a biology-related discipline with 0 - 3 years of relevant industry experience in biologics analytical development, bioassay development, cell line engineering, or functional characterization.\nMaster’s degree in biology-related scientific discipline and 3 years of work experience in biopharmaceutical industry or\nBachelor’s degree in biology-related scientific discipline and 6 years of work experience in biopharmaceutical industry.\nExperience developing analytical cell lines and cell-based potency or functional assays to support biologics development. Strong understanding of receptor biology, cellular signaling, reporter systems, mechanism of action, and their application to potency assay design.\nAt Vertex, we embrace continuous learning and encourage employees to stay informed on advances in AI, technology, automation, and industry trends. We seek talent who bring an external perspective, demonstrate curiosity and sound judgment, and thoughtfully adopt new capabilities that improve decision-making, drive innovation, increase efficiency, and help deliver better outcomes for patients.\nPay Range:\n$102,800 - $154,200Disclosure Statement:\nThe range provided is based on what we believe is a reasonable estimate for the base salary pay range for this job at the time of posting. This role is eligible for an annual bonus and annual equity awards. Some roles may also be eligible for overtime pay, in accordance with federal and state requirements. Actual base salary pay will be based on a number of factors, including skills, competencies, experience, and other job-related factors permitted by law.\nAt Vertex, our Total Rewards offerings also include inclusive market-leading benefits to meet our employees wherever they are in their career, financial, family and wellbeing journey while providing flexibility and resources to support their growth and aspirations. From medical, dental and vision benefits to generous paid time off (including a week-long company shutdown in the Summer and the Winter), educational assistance programs including student loan repayment, a generous commuting subsidy, matching charitable donations, 401(k) and so much more.\nFlex Designation:\nOn-Site DesignatedFlex Eligibility Status:\nIn this On-Site designated role, you will work five days per week on-site with ad hoc flexibility.\nNote: The Flex status for this position is subject to Vertex’s Policy on Flex @ Vertex Program and may be changed at any time.\nCompany Information\nVertex is a global biotechnology company that invests in scientific innovation.\nVertex is committed to equal employment opportunity and non-discrimination for all employees and qualified applicants without regard to a person's race, color, sex, gender identity or expression, age, religion, national origin, ancestry, ethnicity, disability, veteran status, genetic information, sexual orientation, marital status, or any characteristic protected under applicable law. Vertex is an E-Verify Employer in the United States. Vertex will make reasonable accommodations for qualified individuals with known disabilities, in accordance with applicable law.\nAny applicant requiring an accommodation in connection with the hiring process and/or to perform the essential functions of the position for which the applicant has applied should make a request to the recruiter or hiring manager, or contact Talent Acquisition at ","description_format":"text","description_chars":8107,"description_truncated":false,"requirements":{"experience_years_min":6,"management_years_min":null,"team_size_min":null,"manages_managers":false,"education":{"level":"bachelor","optional":false},"security_clearance":false,"languages":[]},"benefits":["Continuous learning","Equity"],"hiring_locations":[],"hiring_excludes":[],"relocation_offered":false,"industries":["Prescription Drugs","Cell & Gene Therapy","Rare Disease Therapeutics"],"lifecycle":[{"event":"open","at":"2026-10-27T00:33:02Z"}],"visa":[{"country":"US","licensed_sponsor":true,"evidence":"H-1B filings in 12 months: 174 · green card filings: 21","filings_12m":174,"filings_prev_12m":187,"green_card_filings_12m":21,"median_offered_wage_usd":131423,"route":null,"cap_exempt":false,"checked_at":"2026-10-29T16:27:21+00:00","sources":["US Department of Labor: LCA disclosure data (H-1B, H-1B1, E-3)","US Department of Labor: PERM disclosure data (green cards)"],"filings_for_role_12m":0}],"liveness":{"score":90,"band":"hot","label":"Hiring now","p_open":1,"p_active":0.903,"p_room":1,"age_days":3,"expected_fill_days":36,"reasons":["conf:3","velocity","win:early","comp:brand"],"computed_at":"2026-10-29T05:49:05Z"},"pay":{"stated_usd_annual":154200,"is_top_pay":true},"html_url":"https://alion.io/job/vertex-pharmaceuticals-analytical-development-research-scientist-2","json_url":"https://alion.io/job/vertex-pharmaceuticals-analytical-development-research-scientist-2.json","meta":{"generated_at":"2026-10-29T16:43:01Z","cache_seconds":300,"methodology":"https://alion.io/methodology","terms":"https://alion.io/terms","contact":"https://alion.io/contact","api":"https://alion.io/developers","about":"Alion is a live layer of people, companies and AI agents: who they are, whether they are real and active right now, what they do and how to work with them, readable by people and by agents and paid per call.","catalog":"https://alion.io/catalog.json","usage":{"tier":"crawler_verified","counted_by":"address","units_charged":1,"used_today":24968,"day_limit":null,"remaining_today":null,"minute_limit":300,"resets_at":"2026-10-30T00:00:00Z"}},"offers":[{"id":"company.slices","title":"One company in depth, by slice","status":"live","price":{"credits":0.02,"usd":0.002,"plus_per_slice":{"credits":0.05,"usd":0.005}},"unit":"per company, plus each slice with data","note":"the employer in depth","call":{"mcp_tool":"get_company","arguments":{"id":5871},"rest":"https://alion.io/mcp/rest/get_company?id=5871"},"human":"https://alion.io/catalog?offer=company.slices&for=job%2Fvertex-pharmaceuticals-analytical-development-research-scientist-2"},{"id":"market.stats","title":"A market slice: pay, demand and time to fill","status":"live","price":{"credits":1,"usd":0.1},"unit":"per slice","note":"pay, demand and time to fill for this role and place","call":{"mcp_tool":"market_stats"},"human":"https://alion.io/catalog?offer=market.stats&for=job%2Fvertex-pharmaceuticals-analytical-development-research-scientist-2"},{"id":"job.search","title":"Open jobs by role, technology, place, pay and visa","status":"live","price":{"credits":0.02,"usd":0.002},"unit":"per posting in a list","note":"similar open postings","call":{"mcp_tool":"search_jobs"},"human":"https://alion.io/catalog?offer=job.search&for=job%2Fvertex-pharmaceuticals-analytical-development-research-scientist-2"},{"id":"company.verify","title":"Is this company real and active right now","status":"pilot","price":null,"unit":"per company","request":{"url":"https://alion.io/catalog/request","method":"POST","body":"{\"offer\": \"company.verify\", \"for\": \"job/vertex-pharmaceuticals-analytical-development-research-scientist-2\", \"note\": \"what you need it for\"}"},"human":"https://alion.io/catalog?offer=company.verify&for=job%2Fvertex-pharmaceuticals-analytical-development-research-scientist-2"}],"agent":{"mcp":"https://alion.io/mcp/jobs","mcp_open":"https://alion.io/mcp/open","next":[{"tool":"get_job","arguments":{"id":3303794}},{"tool":"search_jobs","arguments":{"company":"vrtx.com","detail":"compact"}},{"tool":"match_people","arguments":{"job_id":3303794},"note":"people open to offers who fit this vacancy"}],"note":"The same data through MCP tools: https://alion.io/mcp/open needs no sign-in (compact searches, postings, people); https://alion.io/mcp with an Alion account has everything. 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