{"id":1655275,"url":"https://alion.io/job/vertex-pharmaceuticals-manager-manufacturing-operations-2nd-shift","title":"Manager, Manufacturing Operations (2nd Shift)","company":{"id":5871,"name":"Vertex Pharmaceuticals","domain":"vrtx.com","url":"https://alion.io/company/vrtx","size_band":"5000+","is_staffing_agency":false,"employer_type":"direct","is_intermediary":false,"listed_via":null,"ats_vendor":"Workday","truth_index":{"grade":"A","score":91,"open_postings":24,"ghost_share":0,"stale_share":0.375,"repost_share":0,"time_to_fill_p50_days":38,"computed_at":"2026-10-26T05:57:25Z"}},"role":"Operations","role_family":"Operations","seniority":"middle","employment_type":"full_time","work_mode":"on_site","remote_scope":null,"remote_scope_basis":null,"remote_working_hours":null,"hiring_geo_confidence":"structured","locations":["Boston, United States"],"countries":["US"],"hiring_countries":[],"hiring_countries_total":0,"salary":{"min":119900,"max":179900,"currency":"USD","period":"year","gross":null,"usd_annual":179900},"salary_estimate":null,"experience_years_min":4,"visa_sponsorship":false,"relocation_package":false,"has_equity":true,"technologies":[{"name":"CAPA","optional":false},{"name":"Mandiant capa","optional":false}],"status":"live","first_seen_at":"2026-10-01T00:00:00Z","employer_posted_date":"2026-10-01","last_verified_at":"2026-10-25T08:20:49Z","board_verified":true,"closed_at":null,"days_open":25,"trust":{"level":"ok","repost_count":null,"flags":[],"days_open":25},"description":"Job Description\nGeneral Summary:\nThe Manager, Manufacturing Operations leads cell therapy manufacturing activities and ensures execution aligns with production schedules, operational plans, and business objectives.\nThis role is responsible for defining and directing activities for cell therapy and cell therapy personnel while maintaining organizational balance across the group.\nThis position is accountable for safe, compliant, and efficient cGMP operations, including equipment setup, assembly, operation, disassembly, and cleaning, while providing leadership to supervisors and manufacturing staff. The Manager will foster interdisciplinary communication and understanding within the group and across departments, maintain an audit-ready facility, and support the successful production of pharmaceutical drug products.\nKey Duties and Responsibilities:\nLead and manage daily manufacturing operations.\nProvide leadership, direction, and support to Manufacturing Supervisors and frontline manufacturing personnel.\nDirect the activities of the group through management of staff, prioritization, and assignment of tasks.\nEnsure work is assigned and executed in alignment with detailed production schedules, operational priorities, and business needs.\nResponsible for aligning with site leadership to provide departmental and technical leadership.\nOversee cGMP manufacturing activities, including equipment setup, assembly, operation, disassembly, and cleaning.\nEnsure accurate execution, authoring, review, and approval of batch documentation to maintain compliant manufacturing records.\nExecute and oversee real-time on-the-floor batch record review and escalation of issues as needed.\nAuthor or review and approve batch documentation.\nPartner with cross-functional teams to support facility operations, maintenance activities, investigations, deviations, change controls, and manufacturing objectives.\nMonitor and enforce GMP compliance for all personnel, processes, and activities.\nMaintain the facility in an audit-ready state through adherence to procedures, documentation practices, and inspection readiness standards.\nEnsure compliance with SOPs, policies, and work instructions to support safe and successful facility operation.\nIdentify and continuously improve practices, procedures, and activities related to the department and site.\nDrive operational performance through structured tiered management, including leading Tier 1 meetings and supporting Tier 2 escalation and follow-up as needed.\nMonitor manufacturing performance metrics and identify opportunities to improve safety, quality, delivery, and cost.\nEnable the timely achievement of departmental, site, and corporate goals.\nMentor, motivate, coach, and evaluate the performance of group members.\nLead, coach, and develop supervisors and team members to build organizational capability and support succession planning.\nEnsure personal and team compliance with all training requirements.\nFoster interdisciplinary communication and understanding within the group and with other departments.\nDemonstrate the Vertex Phenotype behaviors: Lead by Example; Learn, Teach & Develop; Foster Exceptional Collaboration; Drive Breakthrough Results; and Promote Enterprise Thinking.\nPerform other duties and projects as assigned to meet departmental and business requirements.\nKnowledge and Skills:\nStrong interpersonal, communication, and organizational skills.\nDemonstrated leadership skills, including the ability to lead through others, develop teams, and drive accountability and performance.\nStrong capability to mentor, motivate, coach, and develop direct reports and emerging leaders.\nEffective interpersonal, verbal, and written communication skills, with the ability to work across functions in a dynamic team environment.\nStrong organizational and operational management skills, with the ability to manage competing priorities and maintain timelines across multiple activities.\nSound understanding of relevant drug development and manufacturing activities, including applicable standard operating procedures (SOPs).\nStrong problem-solving and decision-making skills, with the ability to assess issues, escalate appropriately, and drive resolution.\nAbility to clearly communicate rationale for procedures, practices, and technical approaches.\nDemonstrated competency in the principles and practice of cGMPs and associated regulatory considerations in a pharmaceutical environment.\nSolid understanding of process, equipment, and facility validation requirements.\nSolid understanding of the cGMP framework in both development and commercial pharmaceutical drug product manufacturing environments.\nWorking knowledge of inspection readiness, deviation management, CAPA, change control, and continuous improvement practices.\nProficiency with Quality by Design (QbD) concepts, Design of Experiments (DoE), statistical process control (SPC), and complex data analysis.\nAbility to use manufacturing systems and documentation tools, including QDoCCS and other GMP systems, in support of compliant operations.\nEducation and Experience:\nBachelor’s degree required, preferably in a scientific, technical, or engineering discipline.\n4+ years of experience or the equivalent combination of education and experience.\nPrior people leadership experience required, including experience managing staff, supervisors, and/or manufacturing teams.\nPrior cell therapy and aseptic manufacturing experience preferred.\nPrior POMS MES experience preferred.\nExperience in pharmaceutical manufacturing operations within a cGMP-regulated environment required.\nWork Schedule\nThis position supports our 2nd shift operations. Availability to work other shifts may be necessary to support onboarding, training, and critical manufacturing activities.\n2nd Shift Training Period:\nNew hires will complete an approximately 90-day training program on either first shift or second shift before transitioning to the assigned regular shift.\nTraining will take place between our Cambridge Facility: 100 Tech Drive, and Leiden Center 1 (LC1) in Seaport.\nThe training period will run through January / February 2027, with 5x8hr shifts: Tuesday - Saturday 2:30pm - 11pm.\n\nThe ongoing work shift thereafter will be 4x10hr shifts: Wednesday - Saturday 1pm - 11:30pm\n2nd shift employees are entitled to 10% pay differential\nPlease note that work schedules are based on business needs and may be adjusted or modified as operational requirements evolve. Candidates must be flexible and able to accommodate schedule changes, including shifts, assigned days or hours, as determined by Vertex.\nAt Vertex, we embrace continuous learning and encourage employees to stay informed on advances in AI, technology, automation, and industry trends. We seek talent who bring an external perspective, demonstrate curiosity and sound judgment, and thoughtfully adopt new capabilities that improve decision-making, drive innovation, increase efficiency, and help deliver better outcomes for patients.\nPay Range:\n$119,900 - $179,900Disclosure Statement:\nThe range provided is based on what we believe is a reasonable estimate for the base salary pay range for this job at the time of posting. This role is eligible for an annual bonus and annual equity awards. Some roles may also be eligible for overtime pay, in accordance with federal and state requirements. Actual base salary pay will be based on a number of factors, including skills, competencies, experience, and other job-related factors permitted by law.\nAt Vertex, our Total Rewards offerings also include inclusive market-leading benefits to meet our employees wherever they are in their career, financial, family and wellbeing journey while providing flexibility and resources to support their growth and aspirations. From medical, dental and vision benefits to generous paid time off (including a week-long company shutdown in the Summer and the Winter), educational assistance programs including student loan repayment, a generous commuting subsidy, matching charitable donations, 401(k) and so much more.\nFlex Designation:\nOn-Site DesignatedFlex Eligibility Status:\nIn this On-Site designated role, you will work five days per week on-site with ad hoc flexibility.\nNote: The Flex status for this position is subject to Vertex’s Policy on Flex @ Vertex Program and may be changed at any time.\nCompany Information\nVertex is a global biotechnology company that invests in scientific innovation.\nVertex is committed to equal employment opportunity and non-discrimination for all employees and qualified applicants without regard to a person's race, color, sex, gender identity or expression, age, religion, national origin, ancestry, ethnicity, disability, veteran status, genetic information, sexual orientation, marital status, or any characteristic protected under applicable law. Vertex is an E-Verify Employer in the United States. Vertex will make reasonable accommodations for qualified individuals with known disabilities, in accordance with applicable law.\nAny applicant requiring an accommodation in connection with the hiring process and/or to perform the essential functions of the position for which the applicant has applied should make a request to the recruiter or hiring manager, or contact Talent Acquisition at ","description_format":"text","description_chars":9320,"description_truncated":false,"requirements":{"experience_years_min":4,"management_years_min":null,"team_size_min":null,"manages_managers":false,"education":{"level":"bachelor","optional":false},"security_clearance":false,"languages":[]},"benefits":["Continuous learning","Equity"],"hiring_locations":[],"hiring_excludes":[],"relocation_offered":false,"industries":["Process Manufacturing","Health Care","Cell & Gene Therapy","Rare Disease Therapeutics"],"lifecycle":[{"event":"open","at":"2026-10-02T01:30:56Z"}],"visa":[{"country":"US","licensed_sponsor":true,"evidence":"H-1B filings in 12 months: 174 · green card filings: 21","filings_12m":174,"filings_prev_12m":187,"green_card_filings_12m":21,"median_offered_wage_usd":131423,"route":null,"cap_exempt":false,"checked_at":"2026-10-15T11:24:14+00:00","sources":["US Department of Labor: LCA disclosure data (H-1B, H-1B1, E-3)","US Department of Labor: PERM disclosure data (green cards)"],"filings_for_role_12m":0}],"liveness":{"score":74,"band":"hot","label":"Hiring now","p_open":1,"p_active":0.828,"p_room":0.9,"age_days":25,"expected_fill_days":38,"reasons":["conf:21","velocity","win:mid","comp:brand"],"computed_at":"2026-10-26T05:57:25Z"},"pay":{"stated_usd_annual":179900,"is_top_pay":true},"html_url":"https://alion.io/job/vertex-pharmaceuticals-manager-manufacturing-operations-2nd-shift","json_url":"https://alion.io/job/vertex-pharmaceuticals-manager-manufacturing-operations-2nd-shift.json","meta":{"generated_at":"2026-10-26T09:19:39Z","cache_seconds":300,"methodology":"https://alion.io/methodology","terms":"https://alion.io/terms","contact":"https://alion.io/contact","api":"https://alion.io/developers","about":"Alion is a live layer of people, companies and AI agents: who they are, whether they are real and active right now, what they do and how to work with them, readable by people and by agents and paid per call.","catalog":"https://alion.io/catalog.json","usage":{"tier":"crawler_verified","counted_by":"address","units_charged":1,"used_today":12532,"day_limit":null,"remaining_today":null,"minute_limit":300,"resets_at":"2026-10-27T00:00:00Z"}},"offers":[{"id":"company.slices","title":"One company in depth, by slice","status":"live","price":{"credits":0.02,"usd":0.002,"plus_per_slice":{"credits":0.05,"usd":0.005}},"unit":"per company, plus each slice with data","note":"the employer in depth","call":{"mcp_tool":"get_company","arguments":{"id":5871},"rest":"https://alion.io/mcp/rest/get_company?id=5871"},"human":"https://alion.io/catalog?offer=company.slices&for=job%2Fvertex-pharmaceuticals-manager-manufacturing-operations-2nd-shift"},{"id":"market.stats","title":"A market slice: pay, demand and time to fill","status":"live","price":{"credits":1,"usd":0.1},"unit":"per slice","note":"pay, demand and time to fill for this role and place","call":{"mcp_tool":"market_stats"},"human":"https://alion.io/catalog?offer=market.stats&for=job%2Fvertex-pharmaceuticals-manager-manufacturing-operations-2nd-shift"},{"id":"job.search","title":"Open jobs by role, technology, place, pay and visa","status":"live","price":{"credits":0.02,"usd":0.002},"unit":"per posting in a list","note":"similar open postings","call":{"mcp_tool":"search_jobs"},"human":"https://alion.io/catalog?offer=job.search&for=job%2Fvertex-pharmaceuticals-manager-manufacturing-operations-2nd-shift"},{"id":"company.verify","title":"Is this company real and active right now","status":"pilot","price":null,"unit":"per company","request":{"url":"https://alion.io/catalog/request","method":"POST","body":"{\"offer\": \"company.verify\", \"for\": \"job/vertex-pharmaceuticals-manager-manufacturing-operations-2nd-shift\", \"note\": \"what you need it for\"}"},"human":"https://alion.io/catalog?offer=company.verify&for=job%2Fvertex-pharmaceuticals-manager-manufacturing-operations-2nd-shift"}]}