{"id":3649775,"url":"https://alion.io/job/vertex-pharmaceuticals-portfolio-program-management-director","title":"Portfolio & Program Management Director","company":{"id":5871,"name":"Vertex Pharmaceuticals","domain":"vrtx.com","url":"https://alion.io/company/vrtx","size_band":"5000+","is_staffing_agency":false,"employer_type":"direct","is_intermediary":false,"listed_via":null,"ats_vendor":"Workday","truth_index":{"grade":"A","score":86,"open_postings":28,"ghost_share":0,"stale_share":0.571,"repost_share":0,"time_to_fill_p50_days":38,"computed_at":"2026-11-10T06:52:35Z"}},"role":"Sales","role_family":"Sales","seniority":"head","employment_type":"full_time","work_mode":"hybrid","remote_scope":null,"remote_scope_basis":null,"remote_working_hours":null,"hiring_geo_confidence":"structured","locations":["Boston, United States"],"countries":["US"],"hiring_countries":[],"hiring_countries_total":0,"salary":{"min":162200,"max":243200,"currency":"USD","period":"year","gross":null,"usd_annual":243200},"salary_estimate":null,"experience_years_min":10,"visa_sponsorship":false,"relocation_package":false,"has_equity":true,"technologies":[],"status":"live","first_seen_at":"2026-11-02T23:50:29Z","employer_posted_date":"2026-11-02","last_verified_at":"2026-11-10T07:34:51Z","board_verified":true,"closed_at":null,"days_open":7,"trust":{"level":"ok","repost_count":null,"flags":[],"days_open":7},"description":"Job Description\nPosition Summary:\nThe Director of Portfolio and Program Management (PPM) sits within the COO organization and provides strategic and operational leadership across a portfolio of cross-functional Research programs and projects, spanning early research through candidate preclinical development. The role is accountable for both portfolio-level oversight and direct program management, ensuring alignment with research priorities and delivery against organizational objectives. Working in close partnership with the Cell and Gene Therapies (CGT) Site Head, Chief of Staff, Program Leaders, and cross-functional stakeholders, the Director provides integrated portfolio insights, enables prioritization, drives strategic decision-making, and ensures execution of critical site and program objectives. As a key leader within Research PPM, the Director promotes high-performing, data-driven ways of working, strengthens portfolio governance and visibility, and serves as a trusted thought partner to research leadership. The role also includes line management responsibilities and contributes to the development of PPM capabilities, talent, and organizational effectiveness.\nKey Duties and Responsibilities:\nPartner with Program Leaders to lead portfolio planning, drive strategic decision-making, and ensure effective execution across research and early development programs.\nLead and oversee a portfolio of Research programs and projects from early research through candidate preclinical development, ensuring alignment to organizational and corporate priorities.\nDirectly lead priority cross-functional projects and programs, driving planning, execution, decision-making, and delivery against key milestones and goals.\nPartner closely with the CGT Site Head and Chief of Staff to provide clear, accurate, and timely portfolio and program updates, including status, risks, milestones, resource needs, and decision points, while helping ensure delivery of site objectives.\nGuide cross-functional R&D teams to establish high-performing, data-driven ways of working that deliver on corporate objectives and priorities.\nLead the approach for cross-functional decision-making and issue resolution, identifying key stakeholders and driving alignment on priorities, governance, and actions.\nDevelop and maintain integrated portfolio and project timelines and reporting, defining critical path activities, interdependencies, and potential bottlenecks.\nProactively identify, assess, mitigate, and escalate risks, gaps, challenges, and roadblocks that could impact program or site delivery.\nLead the generation of program assumptions for annual resource allocation and budgeting across Research and Development functions.\nIdentify, communicate, and manage resource constraints, synergies, and redundancies across the portfolio.\nEffectively manage key meetings, stakeholder communications, action items, decisions, and follow-through to support execution and accountability.\nCommunicate complex topics to stakeholders through effective storytelling and content creation.\nEstablish team operating norms and identify opportunities to improve team and portfolio performance.\nWork with Portfolio and Program leadership to build, manage, coach, and retain PM staff.\nServe as a key PPM leader, translating site goals into actionable portfolio and project plans.\nKnowledge and Skills:\nDemonstrated ability to lead a portfolio of complex projects in a fast-paced Research environment.\nStrong ability to partner with senior site leadership to translate strategic priorities into executable plans.\nProven ability to drive accountability and delivery across matrixed cross-functional teams.\nComprehensive knowledge of project and portfolio management principles, best practices, tools, technology and methods.\nLeadership experience managing cross-functional teams.\nExcellent written and oral communication skills, including well-developed presentation skills.\nComprehensive pharmaceutical drug discovery and development knowledge across multiple disciplines.\nExceptional organizational skills and an ability to manage multiple priorities.\nStrong collaboration skills to effectively interact with internal or external stakeholders at all levels of the organization.\nAbility to work in a fast-paced and collaborative environment and manage multiple concurrent projects with a high degree of independence.\nExperience in carrying out Risk Analysis, Decision Analysis and Contingency Planning.\nA desire to be part of a highly innovative company aimed at transforming the lives of people with serious diseases, their families and society.\nAbility to embody the Vertex Core Values of Uncompromising Commitment to Patients, Fearless Pursuit of Excellence, Innovation is Our Lifeblood, and “We” Wins.\nEducation and Experience:\nTypically requires an advanced degree in Life Sciences or a relevant field, (PhD degree preferred or strong demonstration of equivalent combination of relevant educational and professional training).\nTypically requires 10 years of experience, or the equivalent combination of education and experience.\nTypically requires significant experience in portfolio and program management within drug discovery and/or early development, including leadership of cross-functional teams and complex project portfolios.\nAt Vertex, we embrace continuous learning and encourage employees to stay informed on advances in AI, technology, automation, and industry trends. We seek talent who bring an external perspective, demonstrate curiosity and sound judgment, and thoughtfully adopt new capabilities that improve decision-making, drive innovation, increase efficiency, and help deliver better outcomes for patients.\nPay Range:\n$162,200 - $243,200Disclosure Statement:\nThe range provided is based on what we believe is a reasonable estimate for the base salary pay range for this job at the time of posting. This role is eligible for an annual bonus and annual equity awards. Some roles may also be eligible for overtime pay, in accordance with federal and state requirements. Actual base salary pay will be based on a number of factors, including skills, competencies, experience, and other job-related factors permitted by law.\nAt Vertex, our Total Rewards offerings also include inclusive market-leading benefits to meet our employees wherever they are in their career, financial, family and wellbeing journey while providing flexibility and resources to support their growth and aspirations. From medical, dental and vision benefits to generous paid time off (including a week-long company shutdown in the Summer and the Winter), educational assistance programs including student loan repayment, a generous commuting subsidy, matching charitable donations, 401(k) and so much more.\nFlex Designation:\nHybrid-Eligible Or On-Site EligibleFlex Eligibility Status:\nIn this Hybrid-Eligible role, you can choose to be designated as: \n1. Hybrid: work remotely up to two days per week; or select\n2. On-Site: work five days per week on-site with ad hoc flexibility.\nNote: The Flex status for this position is subject to Vertex’s Policy on Flex @ Vertex Program and may be changed at any time.\n#LI-Hybrid\nCompany Information\nVertex is a global biotechnology company that invests in scientific innovation.\nVertex is committed to equal employment opportunity and non-discrimination for all employees and qualified applicants without regard to a person's race, color, sex, gender identity or expression, age, religion, national origin, ancestry, ethnicity, disability, veteran status, genetic information, sexual orientation, marital status, or any characteristic protected under applicable law. Vertex is an E-Verify Employer in the United States. Vertex will make reasonable accommodations for qualified individuals with known disabilities, in accordance with applicable law.\nAny applicant requiring an accommodation in connection with the hiring process and/or to perform the essential functions of the position for which the applicant has applied should make a request to the recruiter or hiring manager, or contact Talent Acquisition at ","description_format":"text","description_chars":8155,"description_truncated":false,"requirements":{"experience_years_min":10,"management_years_min":null,"team_size_min":null,"manages_managers":false,"education":{"level":"phd","optional":false},"security_clearance":false,"languages":[]},"benefits":["Continuous learning","Equity"],"hiring_locations":[{"name":"United States","iso":"US","kind":"country"}],"hiring_excludes":[],"relocation_offered":false,"industries":["Prescription Drugs","Cell & Gene Therapy","Rare Disease Therapeutics"],"lifecycle":[{"event":"open","at":"2026-11-02T23:50:29Z"}],"visa":[{"country":"US","licensed_sponsor":true,"adverts_offering_sponsorship_24m":0,"sanctioned_now":false,"evidence":"H-1B filings in 12 months: 174 · green card filings: 21","filings_12m":174,"filings_prev_12m":187,"green_card_filings_12m":21,"median_offered_wage_usd":131423,"route":null,"cap_exempt":false,"checked_at":"2026-11-10T11:34:35+00:00","sources":["US Department of Labor: LCA disclosure data (H-1B, H-1B1, E-3)","US Department of Labor: PERM disclosure data (green cards)"],"filings_for_role_12m":0}],"liveness":{"score":63,"band":"ok","label":"Likely open","p_open":1,"p_active":0.632,"p_room":1,"age_days":7,"expected_fill_days":38,"reasons":["conf:5","stale_co","velocity","win:early","comp:brand"],"computed_at":"2026-11-10T06:52:35Z"},"pay":{"stated_usd_annual":243200,"is_top_pay":true},"html_url":"https://alion.io/job/vertex-pharmaceuticals-portfolio-program-management-director","json_url":"https://alion.io/job/vertex-pharmaceuticals-portfolio-program-management-director.json","meta":{"generated_at":"2026-11-10T12:43:24Z","cache_seconds":300,"methodology":"https://alion.io/methodology","terms":"https://alion.io/terms","contact":"https://alion.io/contact","api":"https://alion.io/developers","about":"Alion is a live layer of people, companies and AI agents: who they are, whether they are real and active right now, what they do and how to work with them, readable by people and by agents and paid per call.","catalog":"https://alion.io/catalog.json","usage":{"tier":"crawler_verified","counted_by":"address","units_charged":1,"used_today":29590,"day_limit":null,"remaining_today":null,"minute_limit":300,"resets_at":"2026-11-11T00:00:00Z"}},"offers":[{"id":"company.slices","title":"One company in depth, by slice","status":"live","price":{"credits":0.1,"usd":0.01,"plus_per_slice":{"credits":0.05,"usd":0.005}},"unit":"per company, plus each slice with data","note":"the employer in depth","call":{"mcp_tool":"get_company","arguments":{"id":5871},"rest":"https://alion.io/mcp/rest/get_company?id=5871"},"human":"https://alion.io/catalog?offer=company.slices&for=job%2Fvertex-pharmaceuticals-portfolio-program-management-director"},{"id":"market.stats","title":"A market slice: pay, demand and time to fill","status":"live","price":{"credits":2,"usd":0.2},"unit":"per slice","note":"pay, demand and time to fill for this role and place","call":{"mcp_tool":"market_stats"},"human":"https://alion.io/catalog?offer=market.stats&for=job%2Fvertex-pharmaceuticals-portfolio-program-management-director"},{"id":"job.search","title":"Open jobs by role, technology, place, pay and visa","status":"live","price":{"credits":0.1,"usd":0.01},"unit":"per posting in a list","note":"similar open postings","call":{"mcp_tool":"search_jobs"},"human":"https://alion.io/catalog?offer=job.search&for=job%2Fvertex-pharmaceuticals-portfolio-program-management-director"},{"id":"company.verify","title":"Is this company real and active right now","status":"pilot","price":null,"unit":"per company","request":{"url":"https://alion.io/catalog/request","method":"POST","body":"{\"offer\": \"company.verify\", \"for\": \"job/vertex-pharmaceuticals-portfolio-program-management-director\", \"note\": \"what you need it for\"}"},"human":"https://alion.io/catalog?offer=company.verify&for=job%2Fvertex-pharmaceuticals-portfolio-program-management-director"}],"agent":{"mcp":"https://alion.io/mcp/jobs","mcp_open":"https://alion.io/mcp/open","next":[{"tool":"get_job","arguments":{"id":3649775}},{"tool":"search_jobs","arguments":{"company":"vrtx.com","detail":"compact"}},{"tool":"match_people","arguments":{"job_id":3649775},"note":"people open to offers who fit this vacancy"}],"note":"The same data through MCP tools: https://alion.io/mcp/open needs no sign-in (compact searches, postings, people); https://alion.io/mcp with an Alion account has everything. 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