{"id":3433949,"url":"https://alion.io/job/vertex-pharmaceuticals-principal-engineer-microsoft-365-and-copilot-platforms","title":"Principal Engineer, Microsoft 365 and Copilot Platforms","company":{"id":5871,"name":"Vertex Pharmaceuticals","domain":"vrtx.com","url":"https://alion.io/company/vrtx","size_band":"5000+","is_staffing_agency":false,"employer_type":"direct","is_intermediary":false,"listed_via":null,"ats_vendor":"Workday","truth_index":{"grade":"A","score":88,"open_postings":28,"ghost_share":0,"stale_share":0.464,"repost_share":0,"time_to_fill_p50_days":36,"computed_at":"2026-11-05T05:54:30Z"}},"role":"Backend","role_family":"Backend","seniority":"lead","employment_type":"full_time","work_mode":"hybrid","remote_scope":null,"remote_scope_basis":null,"remote_working_hours":null,"hiring_geo_confidence":"structured","locations":["Boston, United States"],"countries":["US"],"hiring_countries":[],"hiring_countries_total":0,"salary":{"min":144000,"max":216000,"currency":"USD","period":"year","gross":null,"usd_annual":216000},"salary_estimate":null,"experience_years_min":null,"visa_sponsorship":false,"relocation_package":false,"has_equity":true,"technologies":[{"name":"Copilot","optional":false},{"name":"Copilot Studio","optional":false},{"name":"GitHub","optional":false},{"name":"Incident Management","optional":false},{"name":"Microsoft Entra ID","optional":false},{"name":"Microsoft Teams","optional":false},{"name":"OneDrive","optional":false},{"name":"Power Apps","optional":false},{"name":"Power Automate","optional":false},{"name":"SharePoint","optional":false}],"status":"live","first_seen_at":"2026-10-28T00:00:00Z","employer_posted_date":"2026-10-28","last_verified_at":"2026-11-05T04:33:26Z","board_verified":true,"closed_at":null,"days_open":8,"trust":{"level":"ok","repost_count":null,"flags":[],"days_open":8},"description":"Job Description\nGeneral Summary:\nThe Principal Engineer, Microsoft 365 and Copilot Platforms serves as the execution-focused technical lead for Microsoft 365 Modern Work and enterprise AI capabilities. This role translates business demand into secure, governed, supportable outcomes. \nThe ideal candidate provides technical leadership across Microsoft Teams, SharePoint Online, OneDrive, Exchange with deep specialization in Microsoft Copilot, GitHub Copilot, Copilot Studio, agents, and AI governance. The role balances approximately 60% hands on work with 40% technical leadership.\nKey Duties and Responsibilities:\nOwn Technical Delivery: Lead Modern Work and AI initiatives, technical design, change control, implementation, working with our operations team. \nLead business escalations, Critical incident management, root cause analysis and troubleshooting. \nLead Microsoft Copilot and AI Enablement: Copilot - SharePoint agents, Cowork \nCopilot Studio - Power Automate, Power Apps \nGitHub & GitHub Copilot \n\nDrive automation and continuous improvement across platforms. \nAct as the technical authority for the team by challenging solution design, coordinating working sessions, and engaging with stakeholders across the business and driving solutions\nCreate and maintain environment documentations, SOP, KB articles for supported technologies\nKnowledge and Skills:\nBroad Microsoft 365 Expertise: Principal- or Lead-level knowledge across Microsoft Teams, SharePoint Online, OneDrive, Exchange, Microsoft 365 governance, and related Entra ID, security, and compliance dependencies.\nDeep practical knowledge of Microsoft Copilot, Copilot Studio, Power Automate and Power Apps, agents, AI governance, and enterprise adoption controls - Agent 365.\nDemonstrated ability to convert broad objectives and business requirements into secure technical designs and completed delivery outcomes.\nAbility to balance business enablement, user experience and operational sustainability in a regulated enterprise environment.\nExperience leading complex technical escalations and coordinating execution across internal teams, control functions, vendors, and managed service providers.\nExcellent written and verbal communication skills, including the ability to explain technical decisions, risks, and recommendations to technical and non-technical audiences.\nStrong analytical and problem-solving skills, with comfort operating through ambiguity, incomplete information, shifting priorities, and multiple dependencies.\nEducation and Experience:\nBachelor's degree (or equivalent degree) in Information Systems, Computer Science, Engineering, Business, or a related discipline, or equivalent professional experience.\nExtensive experience delivering and governing enterprise Microsoft 365 Modern Work capabilities, including ownership of complex technical delivery, operational escalations, and cross-functional implementation.\nExperience implementing Microsoft Copilot, Copilot Studio, enterprise agents, AI governance, or related AI productivity capabilities is strongly preferred.\nExperience working in a regulated enterprise environment and partnering with security, privacy, legal, compliance, identity, and operational teams is strongly preferred.\nAt Vertex, we embrace continuous learning and encourage employees to stay informed on advances in AI, technology, automation, and industry trends. We seek talent who bring an external perspective, demonstrate curiosity and sound judgment, and thoughtfully adopt new capabilities that improve decision-making, drive innovation, increase efficiency, and help deliver better outcomes for patients.\nPay Range:\n$144,000 - $216,000Disclosure Statement:\nThe range provided is based on what we believe is a reasonable estimate for the base salary pay range for this job at the time of posting. This role is eligible for an annual bonus and annual equity awards. Some roles may also be eligible for overtime pay, in accordance with federal and state requirements. Actual base salary pay will be based on a number of factors, including skills, competencies, experience, and other job-related factors permitted by law.\nAt Vertex, our Total Rewards offerings also include inclusive market-leading benefits to meet our employees wherever they are in their career, financial, family and wellbeing journey while providing flexibility and resources to support their growth and aspirations. From medical, dental and vision benefits to generous paid time off (including a week-long company shutdown in the Summer and the Winter), educational assistance programs including student loan repayment, a generous commuting subsidy, matching charitable donations, 401(k) and so much more.\nFlex Designation:\nHybrid-Eligible Or On-Site EligibleFlex Eligibility Status:\nIn this Hybrid-Eligible role, you can choose to be designated as: \n1. Hybrid: work remotely up to two days per week; or select\n2. On-Site: work five days per week on-site with ad hoc flexibility.\nNote: The Flex status for this position is subject to Vertex’s Policy on Flex @ Vertex Program and may be changed at any time.\n#LI-Hybrid\nCompany Information\nVertex is a global biotechnology company that invests in scientific innovation.\nVertex is committed to equal employment opportunity and non-discrimination for all employees and qualified applicants without regard to a person's race, color, sex, gender identity or expression, age, religion, national origin, ancestry, ethnicity, disability, veteran status, genetic information, sexual orientation, marital status, or any characteristic protected under applicable law. Vertex is an E-Verify Employer in the United States. Vertex will make reasonable accommodations for qualified individuals with known disabilities, in accordance with applicable law.\nAny applicant requiring an accommodation in connection with the hiring process and/or to perform the essential functions of the position for which the applicant has applied should make a request to the recruiter or hiring manager, or contact Talent Acquisition at ","description_format":"text","description_chars":6076,"description_truncated":false,"requirements":{"experience_years_min":null,"management_years_min":null,"team_size_min":null,"manages_managers":false,"education":{"level":"bachelor","optional":false},"security_clearance":false,"languages":[]},"benefits":["Continuous learning","Equity"],"hiring_locations":[{"name":"United States","iso":"US","kind":"country"}],"hiring_excludes":[],"relocation_offered":false,"industries":["Prescription Drugs","Cell & Gene Therapy","Rare Disease Therapeutics"],"lifecycle":[{"event":"open","at":"2026-10-29T01:58:57Z"}],"visa":[{"country":"US","licensed_sponsor":true,"evidence":"H-1B filings in 12 months: 174 · green card filings: 21","filings_12m":174,"filings_prev_12m":187,"green_card_filings_12m":21,"median_offered_wage_usd":131423,"route":null,"cap_exempt":false,"checked_at":"2026-10-29T16:27:21+00:00","sources":["US Department of Labor: LCA disclosure data (H-1B, H-1B1, E-3)","US Department of Labor: PERM disclosure data (green cards)"],"filings_for_role_12m":19}],"liveness":{"score":90,"band":"hot","label":"Hiring now","p_open":1,"p_active":0.896,"p_room":1,"age_days":8,"expected_fill_days":36,"reasons":["conf:1","velocity","win:early","comp:brand"],"computed_at":"2026-11-05T05:54:30Z"},"pay":{"stated_usd_annual":216000,"is_top_pay":true},"html_url":"https://alion.io/job/vertex-pharmaceuticals-principal-engineer-microsoft-365-and-copilot-platforms","json_url":"https://alion.io/job/vertex-pharmaceuticals-principal-engineer-microsoft-365-and-copilot-platforms.json","meta":{"generated_at":"2026-11-05T13:30:14Z","cache_seconds":300,"methodology":"https://alion.io/methodology","terms":"https://alion.io/terms","contact":"https://alion.io/contact","api":"https://alion.io/developers","about":"Alion is a live layer of people, companies and AI agents: who they are, whether they are real and active right now, what they do and how to work with them, readable by people and by agents and paid per call.","catalog":"https://alion.io/catalog.json","usage":{"tier":"crawler_verified","counted_by":"address","units_charged":1,"used_today":17573,"day_limit":null,"remaining_today":null,"minute_limit":300,"resets_at":"2026-11-06T00:00:00Z"}},"offers":[{"id":"company.slices","title":"One company in depth, by slice","status":"live","price":{"credits":0.02,"usd":0.002,"plus_per_slice":{"credits":0.05,"usd":0.005}},"unit":"per company, plus each slice with data","note":"the employer in depth","call":{"mcp_tool":"get_company","arguments":{"id":5871},"rest":"https://alion.io/mcp/rest/get_company?id=5871"},"human":"https://alion.io/catalog?offer=company.slices&for=job%2Fvertex-pharmaceuticals-principal-engineer-microsoft-365-and-copilot-platforms"},{"id":"market.stats","title":"A market slice: pay, demand and time to fill","status":"live","price":{"credits":1,"usd":0.1},"unit":"per slice","note":"pay, demand and time to fill for this role and place","call":{"mcp_tool":"market_stats"},"human":"https://alion.io/catalog?offer=market.stats&for=job%2Fvertex-pharmaceuticals-principal-engineer-microsoft-365-and-copilot-platforms"},{"id":"job.search","title":"Open jobs by role, technology, place, pay and visa","status":"live","price":{"credits":0.02,"usd":0.002},"unit":"per posting in a list","note":"similar open postings","call":{"mcp_tool":"search_jobs"},"human":"https://alion.io/catalog?offer=job.search&for=job%2Fvertex-pharmaceuticals-principal-engineer-microsoft-365-and-copilot-platforms"},{"id":"company.verify","title":"Is this company real and active right now","status":"pilot","price":null,"unit":"per company","request":{"url":"https://alion.io/catalog/request","method":"POST","body":"{\"offer\": \"company.verify\", \"for\": \"job/vertex-pharmaceuticals-principal-engineer-microsoft-365-and-copilot-platforms\", \"note\": \"what you need it for\"}"},"human":"https://alion.io/catalog?offer=company.verify&for=job%2Fvertex-pharmaceuticals-principal-engineer-microsoft-365-and-copilot-platforms"}],"agent":{"mcp":"https://alion.io/mcp/jobs","mcp_open":"https://alion.io/mcp/open","next":[{"tool":"get_job","arguments":{"id":3433949}},{"tool":"search_jobs","arguments":{"company":"vrtx.com","detail":"compact"}},{"tool":"match_people","arguments":{"job_id":3433949},"note":"people open to offers who fit this vacancy"}],"note":"The same data through MCP tools: https://alion.io/mcp/open needs no sign-in (compact searches, postings, people); https://alion.io/mcp with an Alion account has everything. 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