{"id":1422444,"url":"https://alion.io/job/vertex-pharmaceuticals-senior-manager-manufacturing-operations-3rd-shift","title":"Senior Manager, Manufacturing Operations (3rd Shift)","company":{"id":5871,"name":"Vertex Pharmaceuticals","domain":"vrtx.com","url":"https://alion.io/company/vrtx","size_band":"5000+","is_staffing_agency":false,"employer_type":"direct","is_intermediary":false,"listed_via":null,"ats_vendor":"Workday","truth_index":{"grade":"A","score":90,"open_postings":25,"ghost_share":0,"stale_share":0.4,"repost_share":0,"time_to_fill_p50_days":38,"computed_at":"2026-10-27T05:46:45Z"}},"role":"Operations","role_family":"Operations","seniority":"senior","employment_type":"full_time","work_mode":"on_site","remote_scope":null,"remote_scope_basis":null,"remote_working_hours":null,"hiring_geo_confidence":"structured","locations":["Boston, United States"],"countries":["US"],"hiring_countries":[],"hiring_countries_total":0,"salary":{"min":139100,"max":208700,"currency":"USD","period":"year","gross":null,"usd_annual":208700},"salary_estimate":null,"experience_years_min":10,"visa_sponsorship":false,"relocation_package":false,"has_equity":true,"technologies":[{"name":"CAPA","optional":false},{"name":"Mandiant capa","optional":false}],"status":"live","first_seen_at":"2026-09-28T22:50:59Z","employer_posted_date":"2026-09-28","last_verified_at":"2026-10-27T08:00:05Z","board_verified":true,"closed_at":null,"days_open":28,"trust":{"level":"ok","repost_count":null,"flags":[],"days_open":28},"description":"Job Description\nGeneral Summary:\nThe Senior Manager, Manufacturing Operations manages a supervisory team and provides oversight to the day-to-day operations.\nThis position provides strategic and operational leadership to ensure safe, compliant, and efficient execution of cGMP manufacturing operations in alignment with production schedules, site objectives, and business priorities. The Senior Manager is accountable for maintaining an audit-ready facility, driving continuous improvement, building organizational capability, and supporting the successful production of pharmaceutical drug products.\nKey Duties and Responsibilities:\nManage and develop a supervisory team, ensuring strong execution, accountability, and team effectiveness.\nDirect the activities of the group through management of staff, prioritization, and assignment of tasks.\nResponsible for aligning with site leadership to provide departmental and technical leadership.\nAssume a project leader role for departmental and interdisciplinary projects.\nEnsure work is prioritized, staffed, and executed in alignment with detailed production schedules and business needs.\nOversee cGMP manufacturing activities, including equipment setup, assembly, operation, disassembly, cleaning, and associated support activities.\nEnsure compliant execution, review, and approval of batch documentation and other GMP records.\nProvide oversight for real-time on-the-floor batch record review and escalation of operational or compliance issues as needed.\nParticipate in event investigations, CAPAs, and change controls in support of production and departmental objectives.\nIdentify and continuously improve practices, procedures, and activities related to the department and site.\nPartner cross-functionally to support validation activities, facility readiness, investigations, and manufacturing objectives.\nEnsure the facility remains in an audit-ready state through adherence to procedures, documentation standards, and inspection readiness practices.\nMonitor and enforce GMP compliance for personnel, processes, and activities.\nDrive operational performance through tiered management systems, including leadership of Tier 1 and/or Tier 2 meetings and follow-up on escalated issues.\nMonitor manufacturing performance metrics and trends; identify risks and drive actions to improve safety, quality, delivery, and cost.\nEnable the timely achievement of departmental, site, and corporate goals.\nMentor, motivate, coach, and evaluate the performance of group members.\nFoster interdisciplinary communication, collaboration, and shared understanding within the group and across departments.\nEnsure personal and team compliance with all training requirements.\nDemonstrate the Vertex Phenotype behaviors: Lead by Example; Learn, Teach & Develop; Foster Exceptional Collaboration; Drive Breakthrough Results; and Promote Enterprise Thinking.\nPerform other duties and projects as assigned to meet departmental and business requirements.\nKnowledge and Skills:\nAdvanced interpersonal, communication, and organizational skills.\nStrong leadership and people management skills, with the ability to lead through others and build high-performing teams.\nDemonstrated ability to mentor and develop supervisors and emerging leaders.\nStrong organizational, planning, and operational management skills, with the ability to manage competing priorities across multiple activities.\nDeep knowledge of cGMP principles and associated regulatory expectations in a pharmaceutical manufacturing environment.\nStrong understanding of cell therapy manufacturing operations, including process execution, equipment operation, and facility support requirements.\nDemonstrated competency in process, equipment, and facility validation experience.\nExperience with event investigations, deviation management, CAPA, change control, and inspection readiness.\nProficiency with Quality by Design (QbD) concepts, Design of Experiments (DoE), statistical process control (SPC), and complex data analysis.\nStrong problem-solving and decision-making skills, with the ability to assess operational risk, escalate appropriately, and drive resolution.\nAbility to improve systems, processes, and team performance through continuous improvement principles.\nAbility to clearly communicate technical and operational rationale for procedures, practices, and manufacturing approaches.\nProficiency with manufacturing systems and documentation platforms, including QDoCCS and other GMP systems.\nEducation and Experience:\nBachelor’s degree required in a scientific, technical, or engineering discipline.\nTypically requires 10+ years of experience or the equivalent combination of education and experience.\nStrong experience in direct people supervision in a cGMP manufacturing environment required.\nSignificant leadership experience in pharmaceutical manufacturing operations within a cGMP-regulated environment required.\nPrior experience managing supervisors and/or manufacturing teams.\nPrior cell therapy and aseptic manufacturing experience.\nPrior POMS MES experience preferred.\nExperience supporting commercial and/or late-stage development manufacturing preferred.\nWork Schedule\nThis position supports our overnight operations. Availability to work other shifts may be necessary to support onboarding, training, and critical manufacturing activities.\n3rd Shift Training Period:\nNew hires will complete an approximately 90-day training program on either first shift or second shift before transitioning to the assigned overnight schedule. Training will take place between our Cambridge Facility: 100 Tech Drive, and Leiden Center 1 (LC1) in Seaport.\nThe training period will run through January / February 2027, with 5x8hr shifts: Sun - Thurs OR Tues- Saturday 7am - 3:30pm. OR Tuesday - Saturday 2:30pm -11pm\nThe ongoing work shift thereafter will be 4x10hr shifts: Sunday - Wed 9pm -7:30am OR Wed - Saturday 9pm - 7:30am\nPlease note that work schedules are based on business needs and may be adjusted or modified as operational requirements evolve. Candidates must be flexible and able to accommodate schedule changes, including shifts, assigned days or hours, as determined by Vertex.\nAt Vertex, we embrace continuous learning and encourage employees to stay informed on advances in AI, technology, automation, and industry trends. We seek talent who bring an external perspective, demonstrate curiosity and sound judgment, and thoughtfully adopt new capabilities that improve decision-making, drive innovation, increase efficiency, and help deliver better outcomes for patients.\nPay Range:\n$139,100 - $208,700Disclosure Statement:\nThe range provided is based on what we believe is a reasonable estimate for the base salary pay range for this job at the time of posting. This role is eligible for an annual bonus and annual equity awards. Some roles may also be eligible for overtime pay, in accordance with federal and state requirements. Actual base salary pay will be based on a number of factors, including skills, competencies, experience, and other job-related factors permitted by law.\nAt Vertex, our Total Rewards offerings also include inclusive market-leading benefits to meet our employees wherever they are in their career, financial, family and wellbeing journey while providing flexibility and resources to support their growth and aspirations. From medical, dental and vision benefits to generous paid time off (including a week-long company shutdown in the Summer and the Winter), educational assistance programs including student loan repayment, a generous commuting subsidy, matching charitable donations, 401(k) and so much more.\nFlex Designation:\nOn-Site DesignatedFlex Eligibility Status:\nIn this On-Site designated role, you will work five days per week on-site with ad hoc flexibility.\nNote: The Flex status for this position is subject to Vertex’s Policy on Flex @ Vertex Program and may be changed at any time.\nCompany Information\nVertex is a global biotechnology company that invests in scientific innovation.\nVertex is committed to equal employment opportunity and non-discrimination for all employees and qualified applicants without regard to a person's race, color, sex, gender identity or expression, age, religion, national origin, ancestry, ethnicity, disability, veteran status, genetic information, sexual orientation, marital status, or any characteristic protected under applicable law. Vertex is an E-Verify Employer in the United States. Vertex will make reasonable accommodations for qualified individuals with known disabilities, in accordance with applicable law.\nAny applicant requiring an accommodation in connection with the hiring process and/or to perform the essential functions of the position for which the applicant has applied should make a request to the recruiter or hiring manager, or contact Talent Acquisition at ","description_format":"text","description_chars":8897,"description_truncated":false,"requirements":{"experience_years_min":10,"management_years_min":null,"team_size_min":null,"manages_managers":false,"education":{"level":"bachelor","optional":false},"security_clearance":false,"languages":[]},"benefits":["Continuous learning","Equity"],"hiring_locations":[],"hiring_excludes":[],"relocation_offered":false,"industries":["Process Manufacturing","Health Care","Cell & Gene Therapy","Rare Disease Therapeutics"],"lifecycle":[{"event":"open","at":"2026-09-28T22:50:59Z"}],"visa":[{"country":"US","licensed_sponsor":true,"evidence":"H-1B filings in 12 months: 174 · green card filings: 21","filings_12m":174,"filings_prev_12m":187,"green_card_filings_12m":21,"median_offered_wage_usd":131423,"route":null,"cap_exempt":false,"checked_at":"2026-10-15T11:24:14+00:00","sources":["US Department of Labor: LCA disclosure data (H-1B, H-1B1, E-3)","US Department of Labor: PERM disclosure data (green cards)"],"filings_for_role_12m":0}],"liveness":{"score":64,"band":"ok","label":"Likely open","p_open":1,"p_active":0.852,"p_room":0.75,"age_days":28,"expected_fill_days":38,"reasons":["conf:5","velocity","win:late","comp:brand"],"computed_at":"2026-10-27T05:46:45Z"},"pay":{"stated_usd_annual":208700,"is_top_pay":true},"html_url":"https://alion.io/job/vertex-pharmaceuticals-senior-manager-manufacturing-operations-3rd-shift","json_url":"https://alion.io/job/vertex-pharmaceuticals-senior-manager-manufacturing-operations-3rd-shift.json","meta":{"generated_at":"2026-10-27T12:05:29Z","cache_seconds":300,"methodology":"https://alion.io/methodology","terms":"https://alion.io/terms","contact":"https://alion.io/contact","api":"https://alion.io/developers","about":"Alion is a live layer of people, companies and AI agents: who they are, whether they are real and active right now, what they do and how to work with them, readable by people and by agents and paid per call.","catalog":"https://alion.io/catalog.json","usage":{"tier":"crawler_verified","counted_by":"address","units_charged":1,"used_today":14445,"day_limit":null,"remaining_today":null,"minute_limit":300,"resets_at":"2026-10-28T00:00:00Z"}},"offers":[{"id":"company.slices","title":"One company in depth, by slice","status":"live","price":{"credits":0.02,"usd":0.002,"plus_per_slice":{"credits":0.05,"usd":0.005}},"unit":"per company, plus each slice with data","note":"the employer in depth","call":{"mcp_tool":"get_company","arguments":{"id":5871},"rest":"https://alion.io/mcp/rest/get_company?id=5871"},"human":"https://alion.io/catalog?offer=company.slices&for=job%2Fvertex-pharmaceuticals-senior-manager-manufacturing-operations-3rd-shift"},{"id":"market.stats","title":"A market slice: pay, demand and time to fill","status":"live","price":{"credits":1,"usd":0.1},"unit":"per slice","note":"pay, demand and time to fill for this role and place","call":{"mcp_tool":"market_stats"},"human":"https://alion.io/catalog?offer=market.stats&for=job%2Fvertex-pharmaceuticals-senior-manager-manufacturing-operations-3rd-shift"},{"id":"job.search","title":"Open jobs by role, technology, place, pay and visa","status":"live","price":{"credits":0.02,"usd":0.002},"unit":"per posting in a list","note":"similar open postings","call":{"mcp_tool":"search_jobs"},"human":"https://alion.io/catalog?offer=job.search&for=job%2Fvertex-pharmaceuticals-senior-manager-manufacturing-operations-3rd-shift"},{"id":"company.verify","title":"Is this company real and active right now","status":"pilot","price":null,"unit":"per company","request":{"url":"https://alion.io/catalog/request","method":"POST","body":"{\"offer\": \"company.verify\", \"for\": \"job/vertex-pharmaceuticals-senior-manager-manufacturing-operations-3rd-shift\", \"note\": \"what you need it for\"}"},"human":"https://alion.io/catalog?offer=company.verify&for=job%2Fvertex-pharmaceuticals-senior-manager-manufacturing-operations-3rd-shift"}]}