{"id":1377127,"url":"https://alion.io/job/vertex-pharmaceuticals-supervisor-manufacturing-operations-second-shift","title":"Supervisor, Manufacturing Operations (Second Shift)","company":{"id":5871,"name":"Vertex Pharmaceuticals","domain":"vrtx.com","url":"https://alion.io/company/vrtx","size_band":"5000+","is_staffing_agency":false,"employer_type":"direct","is_intermediary":false,"listed_via":null,"ats_vendor":"Workday","truth_index":{"grade":"B","score":82,"open_postings":19,"ghost_share":0,"stale_share":0.737,"repost_share":0,"time_to_fill_p50_days":30,"computed_at":"2026-10-01T05:45:00Z"}},"role":"Operations","role_family":"Operations","seniority":"middle","employment_type":"full_time","work_mode":"on_site","remote_scope":null,"remote_scope_basis":null,"remote_working_hours":null,"hiring_geo_confidence":"structured","locations":["Leiden, Netherlands"],"countries":["NL"],"hiring_countries":[],"hiring_countries_total":0,"salary":null,"salary_estimate":{"min_usd":64000,"max_usd":131000,"period":"year","method":"role_seniority_country_remote_cell","sample_n":933},"experience_years_min":3,"visa_sponsorship":false,"relocation_package":false,"has_equity":true,"technologies":[{"name":"Outlook","optional":false}],"status":"live","first_seen_at":"2026-09-28T07:01:38Z","employer_posted_date":"2026-09-28","last_verified_at":"2026-10-02T01:30:53Z","board_verified":true,"closed_at":null,"days_open":3,"trust":{"level":"ok","repost_count":null,"flags":[],"days_open":3},"description":"Job Description\nJob Description\nThe Manufacturing Operations Supervisor is a critical first-line leadership role within Cell Manufacturing. This position is responsible for direct management of personnel executing GMP cell processing operations for adherent and suspension cell cultures. The candidate will have strong leadership skills, GMP expertise, and commitment to patients.\nThe Supervisor will work one of the following shifts:\nSecond Shift - Tuesday to Saturday, 2:30PM - 11PM\nSecond Shift - Sunday to Thursday, 2:30PM - 11PM\nKey Duties and Responsibilities:\nBuilds and develops an efficient team of 2-8 direct reports capable of consistently producing clinical cellular product or intermediates according to cGMP standards. Includes hiring, orienting, training and coaching of personnel.\nEnsures cGMP compliance through direct oversight and education of team members.\nShares responsibility of scheduling of personnel in coordination with other Manufacturing leadership.\nManages direct reports’ projects to achieve department and corporate goals, including managing timelines and leading group meetings.\nLeads, investigates, and collaborates with cross-functional stakeholders regarding quality systems, including quality events, deviations, CAPAs, change controls, and risk assessments.\nCreates, revises, and reviews controlled documents including Standard Operating Procedures (SOPs) and Batch Records for manufacturing.\nReceive and manage equipment alarms.\nServes as a technical SME for the team, troubleshoots problems independently.\nDemonstrates the Vertex Phenotype behaviors: Lead by Example; Learn, Teach & Develop; Foster Exceptional Collaboration; Drive Breakthrough Results; and Promote Enterprise Thinking\nOther duties and projects as assign as required to meet departmental requirements.\n\nKnowledge and Skills:\nExtensive GMP experience, including as a lead or trainer\nMinimum of 3 years of cell culture experience, ideally in both adherent and suspension cultures\nA minimum of 0-2 years direct supervisory experience\nWorking knowledge of federal requirements for GMP manufacturing (21CFR 210,211) and Quality Systems (21CFR 820)\nExpertise in cell processing and culture technologies for clinical materials production required\nExperience with bioreactors for cell culture\nExcellent computer skills including Word, Excel, Project, Outlook, equipment interfaces and electronic quality systems\nEnvironment:\nWorks in a cleanroom and office setting\nMust be able to remain in a stationary position 50% during processing activities\nFrequently move about inside the cleanroom to accomplish process tasks\nOccasionally moves lab equipment and materials weighing up to 50 pounds.\nAt Vertex, we embrace continuous learning and encourage employees to stay informed on advances in AI, technology, automation, and industry trends. We seek talent who bring an external perspective, demonstrate curiosity and sound judgment, and thoughtfully adopt new capabilities that improve decision-making, drive innovation, increase efficiency, and help deliver better outcomes for patients.\nPay Range:\n$0 - $0Disclosure Statement:\nThe range provided is based on what we believe is a reasonable estimate for the base salary pay range for this job at the time of posting. This role is eligible for an annual bonus and annual equity awards. Some roles may also be eligible for overtime pay, in accordance with federal and state requirements. Actual base salary pay will be based on a number of factors, including skills, competencies, experience, and other job-related factors permitted by law.\nAt Vertex, our Total Rewards offerings also include inclusive market-leading benefits to meet our employees wherever they are in their career, financial, family and wellbeing journey while providing flexibility and resources to support their growth and aspirations. From medical, dental and vision benefits to generous paid time off (including a week-long company shutdown in the Summer and the Winter), educational assistance programs including student loan repayment, a generous commuting subsidy, matching charitable donations, 401(k) and so much more.\nFlex Designation:\nOn-Site DesignatedFlex Eligibility Status:\nIn this On-Site designated role, you will work five days per week on-site with ad hoc flexibility.\nNote: The Flex status for this position is subject to Vertex’s Policy on Flex @ Vertex Program and may be changed at any time.\nCompany Information\nVertex is a global biotechnology company that invests in scientific innovation.\nVertex is committed to equal employment opportunity and non-discrimination for all employees and qualified applicants without regard to a person's race, color, sex, gender identity or expression, age, religion, national origin, ancestry, ethnicity, disability, veteran status, genetic information, sexual orientation, marital status, or any characteristic protected under applicable law. Vertex is an E-Verify Employer in the United States. Vertex will make reasonable accommodations for qualified individuals with known disabilities, in accordance with applicable law.\nAny applicant requiring an accommodation in connection with the hiring process and/or to perform the essential functions of the position for which the applicant has applied should make a request to the recruiter or hiring manager, or contact Talent Acquisition at ","description_format":"text","description_chars":5392,"description_truncated":false,"requirements":{"experience_years_min":3,"management_years_min":null,"team_size_min":null,"manages_managers":false,"education":null,"security_clearance":false,"languages":[]},"benefits":["Continuous learning","Equity"],"hiring_locations":[],"hiring_excludes":[],"relocation_offered":false,"industries":["Process Manufacturing","Health Care","Cell & Gene Therapy","Rare Disease Therapeutics"],"lifecycle":[{"event":"open","at":"2026-09-28T07:01:38Z"}],"liveness":{"score":63,"band":"ok","label":"Likely open","p_open":1,"p_active":0.632,"p_room":1,"age_days":2,"expected_fill_days":30,"reasons":["conf:11","stale_co","velocity","win:early","comp:brand"],"computed_at":"2026-10-01T05:45:00Z"},"pay":null,"html_url":"https://alion.io/job/vertex-pharmaceuticals-supervisor-manufacturing-operations-second-shift","json_url":"https://alion.io/job/vertex-pharmaceuticals-supervisor-manufacturing-operations-second-shift.json","meta":{"generated_at":"2026-10-02T02:56:00Z","cache_seconds":300,"methodology":"https://alion.io/methodology","terms":"https://alion.io/terms","contact":"https://alion.io/contact","api":"https://alion.io/developers","usage":{"tier":"crawler","counted_by":"address","units_charged":1,"used_today":3970,"day_limit":5000,"remaining_today":1030,"minute_limit":60,"resets_at":"2026-10-03T00:00:00Z"}}}