ViiV Healthcare (GSK) Scientific Leader, Pre-clinical DMPK Drug Discovery Modeling

ViiV Healthcare is a global specialty HIV company, the only one that is 100% focused on researching and delivering new medicines for people living with, and at risk of, HIV. ViiV is highly mission-driven in our unrelenting commitment to being a trusted partner for all people living with and affected by HIV. Our aim is to think, act, and connect differently through a focus on education and treatment for HIV. We go to extraordinary lengths to deliver the sorts of breakthroughs, both in treatments, care solutions and communities, that really count and take a holistic approach to HIV through developing and supporting sustainable community programs and improving access to care. We are fully committed to push through every challenge until HIV/AIDS is eradicated. ViiV has played a significant part in delivering breakthroughs that have turned HIV into a manageable health condition. We offer the largest portfolio of HIV medicines available anywhere, and we continue our work to cater for the widest possible range of needs in response to the HIV epidemic.

We are aware of how much is at stake for those affected by HIV and we show up 100% committed to the patients every day. Our work culture is fast-paced, diverse, inclusive, competitive, and caring. But ViiV isn’t just somewhere to work - it’s a place to belong, an invitation to bring your very best, and a team full of impact-driven team members who are hungry to make a difference.

While we have been improving lives of HIV patients for 30 years, this is an especially exciting time to be at ViiV, as we evaluate novel approaches to treatment and prevention that could further reduce the impact of HIV on individuals and communities.

The Scientific Leader, Pre-clinical DMPK Drug Discovery Modeling will serve in a matrix leadership role driving model-informed drug discovery across ViiV’s Drug Discovery organization by developing and applying fit-for-purpose modeling and simulation approaches that enable rapid, data-driven decision-making for HIV drug discovery programs. This predominantly discovery-focused role partners closely with DMPK, Medicinal Chemistry, Biology, and Clinical Pharmacology to enable early dose predictions and to guide the design and selection of high-quality clinical candidates as rapidly as possible. You will leverage your expertise in PBPK, IVIVE, PK/PD, formulation and route-of-administration modeling to develop modeling approaches and scalable tools that accelerate decision-making from target validation through candidate selection and into early clinical development for multiple modalities (e.g., small molecules, biologics, ADCs, LNPs, and PROTACs).

This role will be based in Branford, CT or Upper Providence, PA or Waltham, MA and is eligible for a domestic relocation package.

This role will provide YOU the opportunity to lead key activities to progress YOUR career. These responsibilities include some of the following:

• Develop and apply fit-for-purpose mechanistic and translational models (PBPK, IVIVE, PK/PD) to guide drug discovery teams toward the highest-quality clinical candidates

• Translate complex ADME, PK, PD, and translational data into actionable insights for project teams and senior leadership

• Apply modeling expertise across diverse modalities, formulations, and routes of administration, including long-acting therapies

• Build scalable computational tools, workflows, and prototypes that accelerate discovery decisions and candidate optimization

• Establish best practices, standards, and governance for modeling methodologies, tools, and computational workflows

• Contribute to scientific publications, regulatory submissions, and other technical documentation, and represent ViiV externally through regulatory interactions and scientific thought leadership

Why You?

Basic Qualification

We are seeking professionals with the following required skills and qualifications to help us achieve our goals:

• Master’s degree with 7 or more years of post-graduate experience, or a PhD with 4 or more years of post-graduate experience, supporting drug discovery programs from lead optimization to Phase I clinical studies

• Strong understanding of ADME principles and integration of standard DMPK workflows and data streams into empirical (e.g. NCA, compartmental modeling) and mechanistic modeling and simulation (e.g. PBPK, QSP) approaches to support rapid discovery decision-making

• Demonstrated ability to apply modeling and simulation approaches to influence key drug discovery decisions, including lead optimization, candidate selection, dose projection, and development strategy

• Broad computational programming expertise in programming and modeling languages (e.g., R, Python, or equivalent) and modeling platforms (e.g., Simcyp, GastroPlus, Phoenix WinNonLin, etc.) to develop modeling and analysis workflows

• Experience integrating diverse datasets (in vitro, in vivo, clinical, omics where applicable) into unified predictive modeling platforms

• Ability to interpret and communicate modeling results to cross-functional teams, and through written communication such as internal reports and publications

Preferred Qualification

If you have the following characteristics, it would be a plus:

• PhD with 6 or more years of drug discovery experience in DMPK or a related discipline

• Demonstrated experience developing and applying modeling and simulation strategies across diverse modalities and routes of administration, including oral therapies, long-acting injectables, biologics, ADCs, lipid nanoparticles, and other advanced therapeutic platforms

• Experience working across teams, including matrix and functional leadership, and partnering with internal and external experts to deliver quality candidates with speed

• Excellent written, verbal, and presentation skills, including experience communicating scientific concepts to cross-functional teams and key stakeholders

• Experience in infectious disease and/or immunology therapeutic areas

Skills

ADME, Analytical Chemistry, Drug Design, Drug Discovery Process, Drug Metabolism, Drug Research, Drug Target Identification, Metabolism, PBPK Modeling, Pharmaceutical Products, Pharmacokinetics, Pharmacology, Pharmacovigilance, Target Research• If you are based in Cambridge, MA; Waltham, MA; Rockville, MD; or San Francisco, CA, the annual base salary for new hires in this position ranges $141,075 to $235,125. The US salary ranges take into account a number of factors including work location within the US market, the candidate’s skills, experience, education level and the market rate for the role. In addition, this position offers an annual bonus and eligibility to participate in our share based long term incentive program which is dependent on the level of the role. Available benefits include health care and other insurance benefits (for employee and family), retirement benefits, paid holidays, vacation, and paid caregiver/parental and medical leave. If salary ranges are not displayed in the job posting for a specific country, the relevant compensation will be discussed during the recruitment process.

Please visit GSK US Benefits Summary to learn more about the comprehensive benefits program ViiV offers US employees. All ViiV employees receive the same benefits options and plans as GSK employee.

Why Us?

At ViiV Healthcare, we will not rest until we leave no person living with HIV behind. Until the 40 million people living with HIV is down to zero, we will continue searching for new ways to limit the impact of HIV.

We are the only pharmaceutical company solely focused on combating, preventing, and ultimately eradicating HIV and AIDS. At ViiV Healthcare, we do things differently. Born out of a partnership between GSK and Pfizer in 2009, with Shionogi joining in 2012, we are determined to help end the HIV epidemic. We are guided by our mission to leave no person living with HIV behind and it is this mission that unites our employees located across the globe. We combine expertise in research, manufacturing, policy and more to push the boundaries of what people think is possible in HIV treatment and care. As a result of our connection with GSK, we are able to draw on their proud history and resources. This means that you would receive all the employee benefits offered by GSK.

Living our mission of leaving no person living with HIV behind means keeping inclusion and diversity at the heart of everything we do - from our breakthrough innovation, to our diverse portfolio of medicines as well as the work we do to partner with HIV communities.

Having a truly inclusive culture where we’re all able to be ourselves and feel like we belong will make us an even stronger team, better able to perform as a business and deliver on our mission to leave no person living with HIV behind.

If you require an accommodation or other assistance to apply for a job at GSK, please contact the appropriate Recruitment Staff by emailing us at - [email protected]

ViiV is an Equal Opportunity Employer. This ensures that all qualified applicants will receive equal consideration for employment without regard to race, color, religion, sex (including pregnancy, gender identity, and sexual orientation), parental status, national origin, age, disability, genetic information (including family medical history), military service or any basis prohibited under federal, state or local law.

Important notice to Employment businesses/ Agencies

ViiV does not accept referrals from employment businesses and/or employment agencies in respect of the vacancies posted on this site. All employment businesses/agencies are required to contact ViiV's commercial and general procurement/human resources department to obtain prior written authorization before referring any candidates to ViiV. The obtaining of prior written authorization is a condition precedent to any agreement (verbal or written) between the employment business/ agency and ViiV. In the absence of such written authorization being obtained any actions undertaken by the employment business/agency shall be deemed to have been performed without the consent or contractual agreement of ViiV. ViiV shall therefore not be liable for any fees arising from such actions or any fees arising from any referrals by employment businesses/agencies in respect of the vacancies posted on this site.

Please note that if you are a US Licensed Healthcare Professional or Healthcare Professional as defined by the laws of the state issuing your license, ViiV may be required to capture and report expenses ViiV incurs, on your behalf, in the event you are afforded an interview for employment. This capture of applicable transfers of value is necessary to ensure ViiV’s compliance to all federal and state US Transparency requirements. For more information, please visit the Centers for Medicare and Medicaid Services (CMS) website at https://openpaymentsdata.cms.gov/