{"id":3412972,"url":"https://alion.io/job/wehi-research-officer","title":"Research Officer","company":{"id":453098,"name":"WEHI","domain":"wehi.edu.au","url":"https://alion.io/company/wehi","size_band":"1001-5000","is_staffing_agency":false,"employer_type":"direct","is_intermediary":false,"listed_via":null,"ats_vendor":"Workday","truth_index":null},"role":"Science & Research","role_family":"Science & Research","seniority":null,"employment_type":"full_time","work_mode":"on_site","remote_scope":null,"remote_scope_basis":null,"remote_working_hours":null,"hiring_geo_confidence":"structured","locations":["Parkville, Australia"],"countries":["AU"],"hiring_countries":[],"hiring_countries_total":0,"salary":null,"salary_estimate":{"min_usd":62000,"max_usd":110000,"period":"year","method":"role_country_seniority_unknown","sample_n":85},"experience_years_min":null,"visa_sponsorship":false,"relocation_package":false,"has_equity":false,"technologies":[{"name":"CRISPR","optional":true},{"name":"Mass Spectrometry","optional":true},{"name":"PyMOL","optional":true}],"status":"live","first_seen_at":"2026-10-28T18:29:53Z","employer_posted_date":"2026-10-28","last_verified_at":"2026-10-30T10:37:34Z","board_verified":true,"closed_at":null,"days_open":1,"trust":{"level":"ok","repost_count":null,"flags":[],"days_open":1},"description":"Job Title\nResearch OfficerJob Description\nAn exciting opportunity is available for a Research Officer - Biochemistry in Wnt signalling to join the Immunology Division at Australia’s pre-eminent biomedical research institute.\nAbout the Position\nThe Glukhova lab investigates the structural mechanisms of Wnt signalling, with a particular focus on membrane protein complexes and the application of this knowledge for drug discovery.\nWe are seeking a highly motivated and adventurous biochemist to join our multidisciplinary team as a Postdoctoral Research Fellow. You will lead a research project dedicated to understanding the assembly of the Wnt signalosome - a large, heterogeneous membrane complex central to Wnt signalling pathways.\nThis is a hands-on biochemistry role requiring deep expertise in membrane protein biology, protein complex stabilisation, and structural interpretation. You will work at the interface of biochemistry and structural biology, reconstituting and characterising multi-component signalling assemblies for mechanistic and structural studies.\nKey Responsibilities\nLead the biochemical reconstitution and characterisation of membrane complexes, including the design and optimisation of expression, solubilisation, and purification strategies.\nEvaluate and optimise detergent and solubilisation strategies for the extraction and stabilisation of membrane protein complexes, with a critical understanding of how detergent choice affects protein integrity and function.\nDesign and implement strategies to stabilise large, heterogeneous complexes for downstream analysis, including the use of stabilising mutations, nanobodies, dominant-negative accessory proteins\nInterpret published structural data from the Protein Data Bank (PDB) to inform construct design, mutagenesis strategies, and experimental planning.\nPrepare samples suitable for structural studies (cryo-EM or X-ray crystallography), working closely with structural biologists within the group.\nMaintain rigorous experimental records and contribute to manuscripts and grant applications.\nContribute to the intellectual environment of the laboratory and mentor junior researchers where appropriate.\nSelection Criteria\nEssential Knowledge and Skills\nPhD in biochemistry, membrane biology, structural biology, or a closely related discipline. \nDemonstrated expertise in the expression, purification, and biophysical characterisation of membrane proteins and large multi-subunit protein complexes.\nPractical knowledge of detergent chemistry as it applies to membrane protein biochemistry, including experience with a range of detergent classes (e.g., DDM, LMNG, digitonin, GDN) and their effects on protein stability, activity, and complex integrity.\nExperience with strategies for stabilising heterogeneous or transient protein complexes, such as the use of stabilising point mutations, conformation-selective binders, or dominant-negative accessory subunits.\nAbility to access, interpret, and critically evaluate protein structures deposited in the Protein Data Bank, and to use structural information to guide experimental design.\nStrong molecular biology skills, including construct design, cloning, and mutagenesis.\nExperience with mammalian and/or insect cell expression systems (e.g., HEK293, Sf9/Hi5).\nExcellent written and verbal communication skills, with a track record of peer-reviewed publications.\nHigh degree of self-motivation, intellectual curiosity, and a strong drive to pursue ambitious research goals.\nDesirable Knowledge and Skills\nFamiliarity with X-ray crystallography or cryo-EM workflows. \nExperience with biophysical techniques for assessing complex assembly and heterogeneity (e.g. fSEC, SEC-MALS, mass photometry, analytical ultracentrifugation, native mass spectrometry). \nExperience with FACSExperience with generation of stable cell lines and or CRISPR editing. \nExperience with fluorescence- or luminescence-based pharmacology or binding assays. \nFamiliarity with computational tools for structural analysis (e.g., PyMOL, Chimera etc, AlphaFold).\nPersonal Qualities\nIntellectually adventurous, with a willingness to tackle technically challenging and high-risk experiments.\nResilient and resourceful in the face of experimental setbacks.\nStrong collaborative skills, with the ability to work effectively across disciplines (biochemistry, structural biology, pharmacology).\nExcellent organisational skills and attention to detail in both benchwork and data management.\nCommitment to fostering a positive, inclusive, and rigorous research environment. \nTerms of appointment\n This position is available for 2 years in a full time capacity.Salary is Research Employee Level A6-A8 ($107,194-$115,059) depending on qualifications and experience. Very attractive salary packaging options are available for general living expenses, meal entertainment, novated leasing and more. 12% superannuation payable, plus up to a further 5% after the first 6 months of service via our matching superannuation scheme.\nGeneral enquiries can be directed to Lilian Wong - .\nA position description is available here.\nHow to apply\n Please apply by uploading your CV, cover letter and a document addressing the key selection criteria in pdf format.\nApplication Closing Date: Wednesday 11 November 2026.","description_format":"text","description_chars":5310,"description_truncated":false,"requirements":{"experience_years_min":null,"management_years_min":null,"team_size_min":null,"manages_managers":false,"education":{"level":"phd","optional":false},"security_clearance":false,"languages":[]},"benefits":[],"hiring_locations":[],"hiring_excludes":[],"relocation_offered":false,"industries":["Research Institutes"],"lifecycle":[{"event":"open","at":"2026-10-28T18:29:53Z"}],"visa":[],"liveness":{"score":86,"band":"hot","label":"Hiring now","p_open":1,"p_active":0.86,"p_room":1,"age_days":1,"expected_fill_days":21,"reasons":["conf:7","win:early"],"computed_at":"2026-10-30T05:48:23Z"},"pay":null,"html_url":"https://alion.io/job/wehi-research-officer","json_url":"https://alion.io/job/wehi-research-officer.json","meta":{"generated_at":"2026-10-30T13:31:51Z","cache_seconds":300,"methodology":"https://alion.io/methodology","terms":"https://alion.io/terms","contact":"https://alion.io/contact","api":"https://alion.io/developers","about":"Alion is a live layer of people, companies and AI agents: who they are, whether they are real and active right now, what they do and how to work with them, readable by people and by agents and paid per call.","catalog":"https://alion.io/catalog.json","usage":{"tier":"crawler_verified","counted_by":"address","units_charged":1,"used_today":527,"day_limit":null,"remaining_today":null,"minute_limit":300,"resets_at":"2026-10-31T00:00:00Z"}},"offers":[{"id":"company.slices","title":"One company in depth, by slice","status":"live","price":{"credits":0.02,"usd":0.002,"plus_per_slice":{"credits":0.05,"usd":0.005}},"unit":"per company, plus each slice with data","note":"the employer in depth","call":{"mcp_tool":"get_company","arguments":{"id":453098},"rest":"https://alion.io/mcp/rest/get_company?id=453098"},"human":"https://alion.io/catalog?offer=company.slices&for=job%2Fwehi-research-officer"},{"id":"market.stats","title":"A market slice: pay, demand and time to fill","status":"live","price":{"credits":1,"usd":0.1},"unit":"per slice","note":"pay, demand and time to fill for this role and place","call":{"mcp_tool":"market_stats"},"human":"https://alion.io/catalog?offer=market.stats&for=job%2Fwehi-research-officer"},{"id":"job.search","title":"Open jobs by role, technology, place, pay and visa","status":"live","price":{"credits":0.02,"usd":0.002},"unit":"per posting in a list","note":"similar open postings","call":{"mcp_tool":"search_jobs"},"human":"https://alion.io/catalog?offer=job.search&for=job%2Fwehi-research-officer"},{"id":"company.verify","title":"Is this company real and active right now","status":"pilot","price":null,"unit":"per company","request":{"url":"https://alion.io/catalog/request","method":"POST","body":"{\"offer\": \"company.verify\", \"for\": \"job/wehi-research-officer\", \"note\": \"what you need it for\"}"},"human":"https://alion.io/catalog?offer=company.verify&for=job%2Fwehi-research-officer"}],"agent":{"mcp":"https://alion.io/mcp/jobs","mcp_open":"https://alion.io/mcp/open","next":[{"tool":"get_job","arguments":{"id":3412972}},{"tool":"search_jobs","arguments":{"company":"wehi.edu.au","detail":"compact"}},{"tool":"match_people","arguments":{"job_id":3412972},"note":"people open to offers who fit this vacancy"}],"note":"The same data through MCP tools: https://alion.io/mcp/open needs no sign-in (compact searches, postings, people); https://alion.io/mcp with an Alion account has everything. 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