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Quizartinib (AC220) in Patients With FLT3-ITD(+) Relapsed or Refractory Acute Myeloid Leukemia: Final Results of a Randomized Phase 2 Study
Background FLT3-ITD in AML is associated with early relapse and poor survival after treatment with standard chemotherapy Quizartinib is an orally active FLT3-ITD inhibitor A previous Phase 2 study included subjects with FLT3-ITD(+) AML, relapsed/refractor
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A small molecule-kinase interaction map for clinical kinase inhibitors
Kinase inhibitors show great promise as a new class of therapeutics. Here we describe an efficient way to determine kinase inhibitor specificity by measuring binding of small molecules to the ATP site of kinases. We have profiled 20 kinase inhibitors, inc
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