iQ Biosciences

In an antibody-drug conjugate (ADC) experiment, the choice of isotype control shapes how clearly target-specific activity can be separated from background. An isotype control accounts for effects that are not specific to the target, which makes choosing t

ACCESS Newswire Press Release.

Antibody-drug conjugates (ADCs) have made remarkable progress in recent years, combining the specificity of targeted antibodies with the potent cell-killing ability of cytotoxic payloads. As these molecules grow more structurally complex, the design of ap

Introduction to Regulatory T Cells The immune response is an exquisitely controlled event in which lymphocytes expand, secrete cytokines, and kill infected cells in response to foreign pathogens. At the peak of the immune response, extracellular organisms

The terms "warhead" and "payload" typically invoke impressions of weapons and destruction. However, in a more constructive and positive light, these terms are now also commonly associated with antibody-drug conjugates (ADCs), a class of biologics used to

In our previous blog, we discussed antibody-dependent cellular phagocytosis (ADCP), a mechanism of action for therapeutic antibodies that is becoming increasingly appreciated. In vitro and in vivo experiments show that ADCP, a process where phagocytic cel

Therapeutic antibodies can work through various mechanisms of action. They can inhibit ligand-independent dimerization to prevent downstream survival and proliferation signaling pathways or induce apoptosis of target cells. In addition, therapeutic antibo

After summarizing how the complement system can have both anti-tumor and pro-tumor effects, we conclude our blog series on Reis et al. by discussing the clinical aspects of complement as a target and biomarker. As discussed in the previous blogs, the imba

Complement in promotion of tumorigenesis. The imbalance and dysfunction of complement activity and activation can lead to various mechanisms that promote tumorigenesis. These mechanisms can have affects on the immune cells to provide a more favorable tumo

The complement system of the innate immune system has been widely regarded as an early deterrent to infections and a means to clear pathogens by activating a group of proteins that leads to cell lysis, phagocytosis, and inflammation. In addition, the powe