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Liquid biopsy in cardiovascular medicine is usually discussed as a future capability. In one corner of transplant medicine, it's already being used. Donor-derived cell-free DNA (dd-cfDNA) testing for rejection surveillance is in routine clinical use for k

As the liquid biopsy field adopts new analytes beyond cfDNA only, one of the first asks we receive is for "an RNA tube." Yet RNA is not a singular type of molecule. It's a whole family of molecules. The species within that family differ in where they sit,

EDTA prevents clotting. That's what an EDTA tube was built for. It was standardized as a blood anticoagulant in the 1950s, when the goal was keeping cells intact long enough to count them under a microscope, not preserving cell-free DNA in plasma (Banfi,

In 2016, the U.S. Food and Drug Administration approved a cell-free DNA (cfDNA) liquid biopsy for the first time (ASCO, 2016). This test, which detects mutations in cfDNA relevant to non-small cell lung cancer, marked an important step in bringing plasma-

Life science companies rigorously scrutinize model architecture, training methods, assays, and data quality. Yet the physical condition of the sample that produced the data often receives far less scrutiny. It is easy to forget that every dataset derived

Blood-based testing for Alzheimer's disease has moved quickly from research use toward clinical adoption. In 2025, Fujirebio's Lumipulse G pTau 217/β-Amyloid 1-42 Plasma Ratio became the first FDA-cleared blood-based IVD test to aid in identifying amyloid

For most of the history of fatty liver disease, staging fibrosis was a prognostic exercise. It told a clinician how worried to be. It did not tell them what to do, because there was nothing approved to do. That is no longer the case. Two therapies are now

Respiratory testing volume doesn't ramp up gradually - it spikes. Flu A/B, RSV, SARS-CoV-2, and Strep A panels that ran a few times a day in August can run dozens of times a shift by November. That surge strains staffing and turnaround and the QC program

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