Ventus Therapeutics

WALTHAM, Mass. & MONTREAL, January 07, 2026--Ventus Therapeutics, a clinical-stage biopharmaceutical company advancing multiple small-molecule programs for autoimmune, inflammatory, and neurological disorders, today announced the nomination of VENT-04, a

Targeting caspase-4/5 has the potential to address a broad range of inflammatory conditions, including inflammatory bowel disease, hidradenitis suppurativa, severe asthma, and chronic obstructive pulmonary disease VENT-04 is the seventh development candid

L'inhibition des caspases 4 et 5 pourrait permettre de traiter une panoplie de troubles inflammatoires : maladies inflammatoires de l'intestin, hidradénite suppurée, asthme sévère et maladie pulmonaire obstructive chronique Le VENT-04 est le septième cand

Smith AP, Creagh EM. Front Pharmacol. The post Caspase-4 and -5 Biology in the Pathogenesis of Inflammatory Bowel Disease. appeared first on Ventus Therapeutics.

Mi J, Liu Z, Pei S, Wu X, Zhao N, Jiang L, Zhang Z, Bai X. Int Immunopharmacol. The post Mendelian randomization study for the roles of IL-18 and IL-1 receptor antagonist in the development of inflammatory bowel disease. appeared first on Ventus Therapeut

Mokry LE, Zhou S, Guo C, Scott RA, Devey L, Langenberg C, Wareham N, Waterworth D, Cardon L, Sanseau P, Davey Smith G, Richards JB. Sci Rep. 2019 Jun 28;9(1):9386. The post Interleukin-18 as a drug repositioning opportunity for inflammatory bowel disease:

Gao H, Cao M, Yao Y, Hu W, Sun H, Zhang Y, Zeng C, Tang J, Luan S, Chen P. Front Immunol. 2021 Oct 14;12:750841. The post Dysregulated Microbiota-Driven Gasdermin D Activation Promotes Colitis Development by Mediating IL-18 Release. appeared first on Vent

Mu J, Maeda K, Ohashi A, Urano T, Nariai Y, Kamino H, Nakamura M, Yamamura T, Sawada T, Ishikawa E, Murate K, Yamamoto K, Hirose T, Furukawa K, Fujishiro M, Kawashima H. Dig Dis Sci. 2024 Jul;69(7):2573-2585. The post Monoclonal Antibodies Against Mature

Kanai T, Watanabe M, Okazawa A, Nakamaru K, Okamoto M, Naganuma M, Ishii H, Ikeda M, Kurimoto M, Hibi T. Gastroenterology. 2000 Dec;119(6):1514-23. The post Interleukin 18 is a potent proliferative factor for intestinal mucosal lymphocytes in Crohn's dise

Bulek K, Zhao J, Liao Y, Rana N, Corridoni D, Antanaviciute A, Chen X, Wang H, Qian W, Miller-Little WA, Swaidani S, Tang F, Willard BB, McCrae K, Kang Z, Dubyak GR, Cominelli F, Simmons A, Pizarro TT, Li X. J Clin Invest. 2020 Aug 3;130(8):4218-4234. The