Staff ML Engineer, Frontier AI
About Us:
Here at Ambience, we never set out to be just another scribe. We’re building the AI intelligence platform that restores humanity to healthcare and drives meaningful ROI for health systems across the country.
Our technology helps providers focus on delivering great care by removing the administrative burden that pulls them away from patients and away from their most impactful work. Ambience delivers real-time coding-aware documentation and clinical workflow support across ambulatory, emergency and inpatient settings at the top health systems in North America.
Our teams operate relentlessly with extreme ownership to build the best solutions for our health system partners. We value candor, positivity and deep thought - and we expect a lot from each other because we know the problems we’re solving truly matter.
Ambience was ranked #1 for Improving the Clinician Experience in the KLAS Research Emerging Solutions Top 20 Report, recognized by Fast Company as one of the Next Big Things in Tech, named one of the best AI companies in healthcare by Inc., and selected as a LinkedIn Top Startup in 2024 and 2025. We’re backed by Oak HC/FT, Andreessen Horowitz (a16z), OpenAI Startup Fund, and Kleiner Perkins - and we’re just getting started.
The Role:
As a Staff Machine Learning Engineer at Ambience, you will help set the technical direction for the AI systems that power our clinical products. You’ll identify the highest-impact opportunities to improve model behavior, evaluation, post-training, and agentic systems, and lead the design and execution of cross-cutting initiatives.
This is a highly hands-on role with broad technical influence. You’ll work closely with clinicians, product managers, researchers, and engineers to translate cutting-edge research into reliable, production-grade AI systems.
Our engineering roles are hybrid - working onsite at our San Francisco office three days per week.
What You’ll Own:
Define the AI Quality and Evaluation Strategy: Establish how we measure production AI quality across LLM and agentic systems, including automated graders, regression testing, human evaluation, failure taxonomies, and offline-to-online validation.
Drive Production Model Improvement: Identify high-impact failure modes across products and lead improvements across prompting, retrieval, context, routing, data, and post-training. Design experiments that determine the right intervention and prove that improvements hold in production.
Advance Post-Training Capabilities: Shape how Ambience uses techniques such as supervised fine-tuning, preference optimization, reinforcement learning, distillation, and synthetic data to improve model behavior.
Architect Agentic AI Systems: Set technical direction for production systems involving tool use, retrieval, context and state management, routing, orchestration, tracing, and failure recovery.
Build Self-Improving AI Loops: Design the systems that turn production failures and user feedback into better datasets, evaluations, and model behavior, creating scalable improvement flywheels across products.
Shape the AI Roadmap: Co-develop the 12-month technical roadmap, balancing near-term product wins with longer-term research and platform investments.
Raise the Technical Bar: Lead technical reviews, mentor engineers, establish best practices, and create reusable systems and frameworks that improve the effectiveness of the broader AI team.
Stay at the Cutting Edge: Distill insights from recent research in LLMs, agents, post-training, NLP, speech, and multimodal AI, and drive experiments that keep Ambience at the forefront of clinical AI.
Who You Are:
Expert in Production AI Systems 7+ years in production ML, research engineering, or applied AI. Deep expertise with modern LLMs, transformers, and complex production AI systems. Have led or materially shaped consequential AI systems with real production impact. Able to reason across models, data, orchestration, evaluation, serving, and product behavior.
Deep Evaluation Rigor Significant experience designing evaluations for LLMs, agents, or other complex AI systems. Can turn ambiguous product-quality problems into robust metrics, datasets, and experiments. Experienced with grader bias, leakage, contamination, misleading aggregate metrics, regression detection, and offline-online mismatch. Knows how to establish whether a model or system improvement actually translates into better user outcomes.
Agentic Systems Expertise Have built or architected production systems involving multiple models, tools, retrieval, context and state management, routing, orchestration, tracing, and failure recovery. Understand how to evaluate and debug complex agent behavior across model, tool, and system boundaries. Comfortable making architectural decisions that span multiple products or teams.
Post-Training and Model Improvement Expertise Have materially improved model behavior through post-training or model adaptation techniques such as supervised fine-tuning, preference optimization, reinforcement learning, distillation, synthetic data, or related approaches. Understand how data quality, objective design, evaluation, and post-training choices affect downstream model behavior. Know when post-training is the right intervention versus prompting, retrieval, context optimization, routing, or changes to the surrounding system. Have taken model improvements from experimentation through rigorous evaluation and production deployment.
Production-Grade Software Engineer Proficient in Python and modern ML frameworks; PyTorch preferred. Comfortable with modern MLOps, CI/CD, observability, and containerized deployments. Remains deeply hands-on: writes code, inspects traces, analyzes failures, and prototypes solutions.
Data-Centric AI Developer Skilled at building large, high-quality datasets and feedback loops. Experienced using production failures, user feedback, and active learning to improve model and system quality. Able to design data and evaluation infrastructure that creates leverage across multiple teams.
Effective Technical Leader Able to work closely with clinicians, product managers, researchers, and engineers. Strong communicator who can simplify complex AI concepts and build alignment around technical decisions. Comfortable operating in ambiguity, identifying the right problems to solve, and driving execution across multiple workstreams.
Mission-Aligned Passion for healthcare or other mission-driven industries. Thrives in a fast-paced, early-stage environment. Takes broad ownership of technical outcomes and raises the effectiveness of the people around them.
Nice-to-Haves
Experience with realtime voice, conversational AI, or multimodal systems.
Prior work in healthcare, clinical AI, or other regulated, high-stakes industries.
Experience interviewing or hiring ML engineers.
Open-source contributions to ML, agent, evaluation, or post-training tooling.
Why Here:
Our products power specialty-specific note generation, chart-aware diagnosis prediction, and real-time clinical decision support in real clinical settings. The work is deeply technical, but the goal is simple: help clinicians do great work with less friction.
To keep improving, we can't wait around for bigger models. The fastest path is building intelligence that gets better with every encounter - learning from how clinicians actually use the products, what they change, and what outcomes follow.
You will own the hardest model quality problems across our clinical AI suite: coding models that navigate a proprietary million-term ontology with multi-objective precision, a scribe that learns from edit signals without introducing regressions, long-context chart understanding that stays faithful under real clinical complexity, and population-level reasoning that surfaces patterns across patients in a way that's auditable and actionable.
This is not applied ML on clean benchmarks - it's research-grade model work with production stakes, where your improvements directly shape what clinicians experience every day.
Compensation
We offer a base compensation range of approximately $250,000-350,000 per year, exclusive of equity. This intentionally broad range provides flexibility for candidates to tailor their cash and equity mix based on individual preferences. Our compensation philosophy prioritizes meaningful equity grants, enabling team members to share directly in the impact they help create.
Are you outside of the range? We encourage you to still apply: we take an individualized approach to ensure that compensation accounts for all of the life factors that matter for each candidate.
Life at Ambience
Working at Ambience means opting into a high-ownership, high-trust environment built for people who want to grow fast, operate decisively and focus on work that matters. This could be the right place for you if you want to
Work on mission-critical AI technology that directly improves clinicians’ day-to-day lives and health system financial health across some of the most complex, high-stakes workflows in the world.
Join a “dream team” culture where we hire exceptional people, expect exceptional outcomes and invest deeply in feedback and continuous growth. We operate as a championship team, and that means being ok with hard, uncomfortable, ambiguous problems that lead to real greatness.
Operate with real ownership and accountability in an environment where there are no bystanders: If something is broken, we fix it! You will have meaningful autonomy and be expected to drive work to completion.
To help you do your best work, we pair these expectations with benefits intentionally designed to help you feel supported and safe at Ambience and beyond. Some of our key benefits include
Comprehensive medical, dental, and vision coverage for you and your dependents
401(k) with a company match of up to 3% of base salary
A remote-friendly culture (with a San Francisco HQ) and full equipment provisioning to ensure you can work effectively from wherever you’re based.
Parental leave to support your family needs
Annual company-wide off-sites, team off-sites and regular team lunches and all-hands gatherings, with travel, lodging and meals covered
Flexible time off with no annual cap, company-wide holidays and an annual holiday shutdown from December 24-January 1 designed to support real rest and long-term sustainability.
Ambience Healthcare is an equal opportunity employer and is committed to building a diverse and inclusive workplace. We do not discriminate on the basis of race, color, religion, sex, gender identity or expression, sexual orientation, national origin, age, disability, veteran status, genetic information, or any other legally protected status. We encourage applicants from all backgrounds to apply.
Ambience is committed to supporting every candidate’s ability to fully participate in our hiring process. If you need any accommodations during your application or interviews, please reach out to our Recruiting team at [email protected]. We’ll handle your request confidentially and work with you to ensure an accessible and equitable experience for all candidates.
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