428,639open jobs
14,645companies
62,546added this week
Browse all
Salary
$181k – $271k per year
Location
In office (Gaithersburg)
Seniority
Architect · 5+ years exp
Employment
Full-Time
Overview
Company
Impact
Profile match
AstraZeneca is a British-Swedish pharmaceutical company formed in 1999 by the merger of Astra of Sweden and Zeneca of the United Kingdom, and now one of the largest drug makers in the world by revenue. Its portfolio is concentrated in oncology with Tagrisso, Imfinzi and Enhertu, alongside cardiovascular, renal and metabolic products including Farxiga, respiratory and immunology medicines, and a rare disease business built on the acquisition of Alexion. Headquartered in Cambridge in England and listed in London, Stockholm and New York, it reports in United States dollars.

At AstraZeneca, we are changing the way cancer is treated through science, innovation, and a deep commitment to patients. Our ambition in Oncology is bold: to redefine cancer care, transform outcomes, and bring life-changing medicines to people around the world.

As one of the fastest-growing areas of our business, Oncology combines a world-class pipeline, market-leading brands, and a relentless focus on scientific advancement. Joining this team means working at the forefront of one of the most dynamic and meaningful areas in healthcare.

We are looking for a Director, Global Commercial, HER2-ADC to join our Global Oncology Franchise Team in Gaithersburg, MD. This is a high-impact global role for an experienced commercial leader whose strongest asset is brand strategy and who thrives in shaping growth beyond a single indication. You will help define how HER2 ADC evolves across tumor types, lead pan-tumor initiatives, shape above-brand strategy, and influence the commercial choices that will shape the brand’s future. You will partner closely with global indication leads, cross-functional colleagues, regional leads and markets.

Who you are: The ideal candidate combines strategic thinking with strong execution discipline and will play a central role in shaping the brand’s long-term commercial direction. This role is particularly well suited to someone who is energized by enterprise-level brand strategy and skilled at bringing diverse stakeholders together around a shared ambition.

What you will do: Working across the organization, you will translate scientific opportunities, customer insights, and evolving market dynamics into clear strategic choices that drive sustainable growth and improve outcomes for patients.

Key accountabilities

Lifecycle and future planning

  • Lead competitive readiness efforts around emerging threats, monitoring the fast-evolving landscape across indications and translating developments into actionable commercial implications.
  • Play a key role in developing cross-functional lifecycle strategies to maximize the brand’s value throughout its lifecycle and prepare for the transition to post-exclusivity competition.
  • Develop key strategic presentations for leadership

Above-indication strategy and brand evolution

  • Drive key elements of the above-indication Brand Strategy Plan, developing strategic content and building alignment across a broad cross-functional network (Market Access, Medical, Diagnostics, regional leads).
  • Ensure seamless execution of key cross-indication initiatives and asset delivery
  • Shape the evolution of the brand positioning and narrative, to solidify leadership in a rapidly evolving oncology landscape.

Market and external expert engagement

  • Design and implement an innovative market engagement model, leveraging new technologies to enable ongoing dialogue with markets and accelerate the sharing and adoption of best practices across countries.
  • Optimize engagement with key external experts across indications, ensuring insights are systematically captured, synthesized, and translated into commercial priorities and actions.

Essential skills and experience

  • Bachelor's degree in a relevant field, preferably in a scientific or business discipline.
  • 5+ years of experience in the pharmaceutical and/or healthcare industry across brand marketing, sales, market research or analytics, strategic planning, or related commercial roles.
  • Strong marketing experience, including brand strategy, positioning, messaging, segmentation, targeting, agency management and annual planning.
  • Experience in oncology marketing, with global launch or lifecycle management experience preferred.
  • Demonstrated ability to translate complex scientific and market information into clear commercial implications and action.
  • Strong project leadership skills and the ability to manage multiple priorities in a matrixed environment.
  • Demonstrated ability to lead without authority and influence across functions, markets and teams.
  • Strong clinical acumen, scientific curiosity and commercial judgement.
  • Entrepreneurial mindset, comfort with ambiguity and a track record of improving ways of working.

Desirable skills and experience

  • Prior oncology marketing experience, ideally in breast cancer or another solid tumor setting.
  • Experience working across global, regional and local market teams.
  • Experience across personal, non-personal, digital and patient-focused channels.
  • Sales or customer-facing experience.
  • MBA or advanced degree in a related field
  • Experience working in a commercial alliance/partnership environment

The annual base pay (or hourly rate of compensation) for this position ranges from $ 180,656.80 - $270,985.20USD Annual. Our positions offer eligibility for various incentives-an opportunity to receive short-term incentive bonuses, equity-based awards for salaried roles and commissions for sales roles. Benefits offered include qualified retirement programs, paid time off (i.e., vacation, holiday, and leaves), as well as health, dental, and vision coverage in accordance with the terms of the applicable plans.

Date Posted

09-Sep-2026

Closing Date

22-Sep-2026

Our mission is to build an inclusive environment where equal employment opportunities are available to all applicants and employees. In furtherance of that mission, we welcome and consider applications from all qualified candidates, regardless of their protected characteristics. If you have a disability or special need that requires accommodation, please complete the corresponding section in the application form.

Free account
Stop reading job ads. Get the ones that fit.
One free account turns this page into a shortlist built around your stack, your level and your pay.
Match on every job. Stack, seniority, pay and location, scored against your profile.
428,639 open roles. Read straight off company career pages, refreshed every day.
Unlimited applications. Every one you send is tracked in one place, on-site or on a company board.
3 tailored CVs a month. Rewritten for the exact job you are applying to. Included free.
Create a free account
Free forever. No card. Under a minute.

Recommended for you based on this role

Similar stack
Same company
Gaithersburg
$53k – $98k per year (Estimated) • Remote/Hybrid • Full-Time • 2+ years exp • Bachelor's Degree • Mississauga
Apply
$127k – $167k per year • Remote/Hybrid • Full-Time • 5+ years exp • Bachelor's Degree • Gaithersburg
Python
JavaScript
TypeScript
Node JS
Python
SQLAlchemy
FastAPI
Databases
PostgreSQL
DynamoDB
Apache Kafka
AI/ML
Copilot
Cursor
Claude
Claude Code
Model Context Protocol
Langfuse
LiteLLM
AWS Bedrock
RAG
Frontend
Tailwind CSS
Next.js
React.js
Vite
Radix UI
shadcn/ui
pnpm
DevOps
GitHub Actions
OpenTelemetry
AWS CDK
AWS
Docker
Kubernetes
Amazon EKS
AWS Fargate
GitHub
Amazon S3
Amazon ECS
Apply
$75k – $141k per year • In office • Full-Time • 2+ years exp • Bachelor's Degree • Santa Barbara
Apply
$151k – $227k per year • In office • Full-Time • 5+ years exp • Bachelor's Degree • Gaithersburg
Apply
$232k – $348k per year • In office • Full-Time • 10+ years exp • Bachelor's Degree • Gaithersburg
Apply
$125k – $188k per year • In office • Full-Time • 5+ years exp • Bachelor's Degree • Gaithersburg
Apply
$151k – $227k per year • In office • Full-Time • 3+ years exp • Bachelor's Degree • Gaithersburg
Apply
$106k – $125k per year • In office • Full-Time • 5+ years exp • Bachelor's Degree • Gaithersburg
Management
SharePoint
Apply
$140k – $210k per year • In office • Full-Time • 5+ years exp • Bachelor's Degree • Gaithersburg
AI/ML
Copilot
Claude
Devin
DevOps
GCP
CI/CD
Cybersecurity
GDPR
Apply
$58k – $81k per year • In office • Full-Time • Gaithersburg
Apply
See all jobs
This is one of many
428,639 more open roles from verified company boards, updated every day.