Senior Director, Mavacamten Medical Product Lead
At Bristol Myers Squibb, our employees often ask, “Who are you working for?”-a question that fuels collaboration, accountability, and urgency in our work. Our purpose-driven culture inspires us to discover, develop, and deliver innovative medicines to prevail over serious diseases. We offer uniquely interesting and meaningful work, opportunities for growth, and a supportive environment that values inclusion, wellbeing, flexibility, and comprehensive benefits. This is work that transforms the lives of patients, and the careers of those who do it.
This position plays a critical role in the development and execution of BMS' WW & US medical strategy within our Mavacamten (Camzyos®) cardiovascular portfolio. The Global Medical Mavacamten Medical Product Lead (MPL) is a strategic leader with a broad scope of responsibilities within the Worldwide Medical organization and a key leader of the cross-functional matrix, providing medical insights and interpretation of the evolving cardiomyopathy landscape and disseminating clinical data across the organization. The MPL has overall accountability to develop aligned medical strategies and execute core medical deliverables, including Integrated Evidence Plans, Scientific Narratives, and External Engagement and Advocacy plans as the lead of the cross-functional Asset/Indication Medical Strategy (AIMS) team.
The Senior Director, MPL will have oversight over the Mavacamten asset across the full spectrum of hypertrophic cardiomyopathy (HCM) indications - both obstructive (oHCM) and non-obstructive (nHCM) - and related life cycle management opportunities, and should be able to direct and navigate complex issues across the broad cross-functional matrixed partners to ensure optimal medical affairs strategy is developed and executed.
Develop and execute the WW & US Medical Affairs strategy for Mavacamten (Camzyos®) across all HCM indications, including obstructive and non-obstructive HCM, ensuring alignment with the overall BMS cardiovascular disease area strategy.
Act as the core global medical representative for WW & US Mavacamten Program Teams, providing strategic medical and scientific leadership across all cross-functional forums.
Lead the cross-functional Asset/Indication Medical Strategy (AIMS) team for Mavacamten, setting strategic direction and aligning medical deliverables across global markets.
Ensure Mavacamten is effectively positioned within the BMS cardiovascular disease area strategy, integrating competitive intelligence and an evolving understanding of the cardiomyopathy landscape.
Participate in the Cardiovascular Leadership Team (LT) to drive business priorities and represent the medical affairs perspective at the highest organizational levels.
Oversee and guide asset development strategy across the full Mavacamten life cycle, including new indications, label expansions, and post-marketing evidence generation in HCM and related cardiomyopathies.
Develop and execute WW & US medical strategy, scientific narratives, and provide medical insights to inform the global medical plan for Mavacamten, with deep expertise in myosin inhibition and cardiac muscle physiology.
Lead workstreams to identify evidence gaps and develop comprehensive Integrated Evidence Plans (IEPs), including both interventional and non-interventional research strategies in HCM populations globally.
Establish and oversee global medical data generation strategies; collaborate with Medical Evidence Generation (MEG) to oversee the execution of Investigator Sponsored Research (ISR) programs for Mavacamten from concept through full execution, including reporting at scientific congresses, in peer-reviewed publications, and through proactive/reactive BMS communication tools.
Deliver WW & US Medical Communications plans for Mavacamten, including global publications strategy, symposia, scientific exchange, and data dissemination at key cardiovascular congresses (e.g., AHA, ACC, ESC, HFSA).
Engage with high-impact global external thought leaders and cardiovascular experts in HCM to identify and translate key insights, and drive adoption of Mavacamten/Camzyos® across global markets.
Partner closely with colleagues in Discovery, Clinical Research, Regulatory, and Health Outcomes to ensure the science of Mavacamten and the broader cardiovascular pipeline is understood and communicated properly, both internally and externally.
Contribute to shaping competitive strategies around pricing and reimbursement by providing the global medical perspective on the target product profile, label language, and value considerations for Mavacamten.
Demonstrate the ability to make effective decisions on selecting external organizations and researchers with appropriate cardiovascular/HCM expertise for research collaborations globally.
Shape and represent BMS' scientific leadership in cardiomyopathy at international scientific meetings, advisory boards, and with key global health authorities and cardiology societies.
Qualifications & Experience
Life sciences and/or healthcare professional training with an advanced degree is required (MD, PharmD, PhD).
Minimum of 8+ years working in the pharmaceutical industry (Medical Affairs/Medical Strategy, Clinical Research) with experience in cardiovascular medicine, preferably with direct experience in cardiomyopathy, heart failure, or related therapeutic areas.
Deep scientific knowledge of hypertrophic cardiomyopathy (HCM) - including disease pathophysiology, treatment landscape, and the clinical evidence base for myosin inhibition - is preferred.
The successful candidate should have strong analytical skills, strong scientific data and evidence interpretation + contextualization, and the ability to work effectively with cross-functional teams including clinical, commercialization, regulatory, HEOR and Access.
Excellent strategy development, critical thinking, decision making, and demonstrated ability to successfully create and implement both short and long-range global medical plans.
Proven track record of engaging global/international KOLs and cardiovascular thought leaders; demonstrated ability to build and sustain high-impact external scientific relationships.
Experience leading global medical affairs programs and working effectively in a worldwide matrixed organization across multiple geographies and cultures.
Entrepreneurial thinking, anticipates needs, assesses and manages business and organizational risks in a complex global environment.
Highly organized and motivated and possesses excellent people management, interpersonal, and strong communication skills.
Must be familiar with all phases of drug development, including clinical development, regulatory, and life cycle management in a global context.
Launch expertise in cardiovascular therapeutic area, preferably with experience in rare cardiovascular disease or specialty cardiology.
HQ based position with international/domestic travel requirement approximately 20-30%.
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Compensation Overview:
Princeton - NJ - US: $229,380 - $277,956The starting pay range(s) listed above is for full-time employees (FTE). You may also be eligible for additional discretionary incentive cash and stock opportunities. We determine starting pay thoughtfully - carefully considering the nature of the role, required skills, work location, schedule and the knowledge and experience you bring. Final compensation is guided by pay equity principles and applicable employment laws. Compensation programs are reviewed on an ongoing basis and may be adjusted over time to reflect evolving market factors, and individual, team or Company performance.
Benefits:
Subject to the terms and conditions of the applicable plans then in effect, you may be eligible to participate in our comprehensive benefit plans - including wellbeing support, retirement and financial protection benefits, and insurance offerings (medical, dental, vision, life and disability).
U.S.-based exempt employees are eligible for Flexible Time Off (FTO), which provides paid time off without a set accrual limit, subject to manager approval, along with 11 paid company holidays each year.
Non-exempt employees, RayzeBio employees, and employees located in Puerto Rico receive 160 hours of paid vacation annually for new hires (subject to manager approval), 11 paid company holidays, and 3 optional holidays.
Depending on eligibility, employees may also have access to additional time-off benefits, including paid sick leave, up to two paid volunteer days per year, summer hours flexibility, and leaves of absence for medical, personal, parental, caregiver, bereavement, or military needs. Eligible employees also enjoy an annual Global Shutdown between Christmas Day and New Year's Day.
U.S.-based job seekers can explore full benefit offerings athttps://careers.bms.com/benefits
How We Work
Where you work matters - because collaboration, innovation and patient impact happen in many settings. Our roles are structured across four work models: site-essential, site-by-design, field-based and remote-by-design. The model assigned to this role is based on its core responsibilities. Learn more at https://careers.bms.com/ways-of-working.
Supporting People with Disabilities
BMS is dedicated to ensuring that people with disabilities can excel through a transparent recruitment process, reasonable workplace accommodations/adjustments and ongoing support in their roles. Applicants can request a reasonable workplace accommodation/adjustment prior to accepting a job offer. If you require reasonable accommodations/adjustments in completing this application, or in any part of the recruitment process, direct your inquiries to [email protected]. Visit careers.bms.com/eeo-accessibility to access our complete Equal Employment Opportunity statement.
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R1603604 : Senior Director, Mavacamten Medical Product Lead