2,110,344open jobs
130,027companies
243,042added this week
Browse all
Location
In office (San Francisco)
Visa
H-1B filings in 12 months: 2 · for this role: 1
Employment
Full-Time

Confirmed on the employer's own hiring board on Nov 5, 2026. First seen by Alion on Nov 4, 2026. Chai Discovery scores A on the Alion truth index.

Overview
Company
Impact
Profile match
Chai Discovery is a San Francisco research company founded in 2024 that builds foundation models for molecular structure and interaction prediction. Its Chai-1 model predicts complexes of proteins, small molecules, nucleic acids and antibodies, and was released for free non-commercial use alongside a commercial offering. The company is backed by OpenAI and Thrive Capital and targets the design of antibodies and other biologics.

About Chai Discovery

Chai Discovery builds the computer-aided design suite for molecules. Eli Lilly, GSK, Pfizer, Bristol Myers Squibb, argenx and Novartis all use Chai to power drug discovery programs. AI is reinventing life sciences the same way it reinvented software engineering, and our team is building that future.

We train frontier models that learn the underlying foundations of biochemical structure and interaction. We pair this with a computational workspace to iterate on molecules from idea to medicine, helping scientists move faster and develop medicines beyond the reach of existing methods.

We value diverse perspectives and are ready to find greatness in unexpected places.

About the role

We are hiring research scientists to work on foundation model pre-training. Our models learn the foundations of molecular structure and interaction, and their success depends on carefully designed architectural components, training objectives, and data mixes.

At Chai, pre-training research is largely domain-agnostic: understanding model architecture, reading training curves, and knowing when to move between phases of a recipe. We are biased toward simplification, generality, and scale. We adapt the best ideas from frontier language, image, and video models into our domain.

Our models have moved beyond protein structure prediction into real-world therapeutic engineering, and you will have the compute and the team to push that further.

About you

We look for researchers with a strong track record, which can take many forms: getting a model to work, developing impactful theory, or making a substantial contribution to the field. In particular we look for:

  • Depth in generative modelling, model architecture, or scaling laws.

  • Hands-on experience designing and training large models.

  • Theoretical grounding in CS, ML, math, or physics.

We are happy to bet on rising talent.

We offer

The opportunity to work at the vanguard of AI research and frontier biology, with world-class people, on a mission that matters. We protect and promote a culture of high velocity and ownership. We compensate our team accordingly.

Free account
Stop reading job ads. Get the ones that fit.
One free account turns this page into a shortlist built around your stack, your level and your pay.
Match on every job. Stack, seniority, pay and location, scored against your profile.
2,110,344 open roles. Read straight off company career pages, refreshed every day.
Unlimited applications. Every one you send is tracked in one place, on-site or on a company board.
3 tailored CVs a month. Rewritten for the exact job you are applying to. Included free.
Create a free account Continue with Google
Free forever. No card. Under a minute.

Your match

How well do you fit this role?
Two answers are enough for a real match. No account needed.
Check my fit
Answers stay in this browser until you create an account.

Recommended for you based on this role

AI/ML
Similar stack
Same company
San Francisco
AI Web Developer T4 2 days ago
$104k – $218k per year · In office · TS/SCI · Full-Time · 2+ years exp · Bachelor's Degree · Chantilly
Python
JavaScript
SQL
C#
C#
.NET
AI/ML
Model Context Protocol
Prompt Engineering
Function Calling
AWS Bedrock
LLM
RAG
Amazon SageMaker
Frontend
Bootstrap
DevOps
AWS
AWS Lambda
Amazon ECS
Amazon CloudWatch
Management
Agile
Apply
AI Developer T5 2 days ago
$121k – $266k per year · In office · TS/SCI · Full-Time · 2+ years exp · Bachelor's Degree · Chantilly
Python
JavaScript
SQL
C#
C#
.NET
AI/ML
Model Context Protocol
Prompt Engineering
Function Calling
AWS Bedrock
LLM
RAG
Amazon SageMaker
Frontend
Bootstrap
DevOps
AWS
AWS Lambda
Amazon ECS
Amazon CloudWatch
Management
Agile
Apply
Research Engineer 1 hour ago
$150k – $200k per year · Remote (United States) · Full-Time · San Francisco
AI/ML
Reinforcement Learning
Function Calling
AI Agents
PyTorch
Post-training
Machine Learning
Apply
$130k per year · In office · TS/SCI · 5+ years exp · Bachelor's Degree · Annapolis Junction
AI/ML
Machine Learning
MedTech
Verification & Validation
Apply
$263k – $300k per year · In office · Full-Time · 5+ years exp · Master's Degree · New York · McLean · Cambridge · San Jose
AI/ML
Fine-tuning
RLHF
Quantization
NLP
Transfer Learning
PyTorch
LLM
Self-Supervised Learning
Hugging Face
SFT
Pre-training
Machine Learning
DevOps
AWS
Apply
In office · 8+ years exp · Bachelor's Degree · San Francisco
Marketing
Google Ads
Apply
In office · 8+ years exp · Bachelor's Degree · San Francisco
Apply
In office · 10+ years exp · Bachelor's Degree · San Francisco
DevOps
GCP
Apply
In office · 10+ years exp · San Francisco
Apply
In office · 2+ years exp · Bachelor's Degree · San Francisco
Life Sciences
GMP
Apply
See all jobs
This is one of many
2,110,344 more open roles from verified company boards, updated every day.