Principal Scientist, Pathology

Grow Your Career Where Talent Meets Innovation

Take a Look at Your Future with Crown Bioscience

A path towards your most rewarding career. The mission of Crown Bioscience is to address the unmet needs in life science by creating and supplying innovative translational technologies and platforms. Our products and services have been profoundly expediting research for in vitro, in vivo, translational oncology, target validation, preclinical proof of concept, assistive clinical strategy design, and biomarker discovery.

PRIMARY RESPONSIBILITIES

This role sits within an integrated PK/PD, Toxicology, and Biomarker platform supporting translational drug development. You'll gain exposure to novel drug modalities (ADC, IO, cell therapy, etc) and collaborate cross-functionally with PK/PD and toxicology scientists, building a well-rounded understanding of preclinical and translational drug development.

• Independently perform, analyze, and interpret pathology and tissue-based biomarker assays, including IHC , IF/multiplex IF, and RNAscope or ISH, etc.
• Review IHC/histopathology sections and analyze IHC and mIF results, including image capture, scoring analysis, and scientific interpretation.
• Conduct image analysis and data interpretation using AI-based platforms such as HALO and HALO AI; support algorithm development and validation for quantitative biomarker analysis.
• Support the development, optimization, troubleshooting, and validation of IHC/pathology and biomarker assays.
• Support advanced spatial pathology and multiplex imaging workflows. Experience with Akoya platforms, such as OPAL multiplex IF, PhenoImager, or related spatial biology technologies, is preferred.
• Support pathology platform R&D activities, including development of new biomarker assays, multiplex panels, digital pathology workflows, and spatial biology capabilities.
• Support pathology and biomarker studies for ADC, immuno-oncology, targeted therapy, small-molecule, and other drug discovery programs.
• Communicate effectively with customers, project teams, and cross-functional stakeholders in China and globally.
• Draft study protocols, assay plans, data summaries, and final study reports, and deliver high-quality data to customers in a timely manner.
• Provide technical training and guidance to new employees and junior team members.
• Complete other assignments from upper management.

EDUCATION AND EXPERIENCE

• Ph.D. in pathology, veterinary pathology, immunology, cancer biology, molecular biology, cell biology, medicine, veterinary medicine, or a related field.
• Knowledge and hands-on experience in cancer biomarkers, molecular biology, histopathology, veterinary medicine, or tissue-based biomarker assays.
• Experience in preclinical drug discovery, CRO, pharmaceutical, biotechnology, or translational research environments is preferred.

SKILL REQUIREMENTS

• Proficient in core molecular biology and histopathology techniques, including IHC, IF, ISH/RNAscope, etc.
• Hands-on experience with complex/advanced pathology platforms such as Multiplex IF and spatial biology platform is preferred.
• Familiarity with digital pathology image analysis platforms (e.g., HALO, HALO AI) is highly preferred.
• Understanding of digital pathology applications in ADC, IO, targeted therapy, and small-molecule drug development is strong preferred.
• Capable of independently performing experiments, analyzing data, troubleshooting technical issues, and drafting scientific study reports.
• Detail-oriented with strong data management and documentation practices.
• Excellent English communication skills (written and verbal), with the ability to interface directly with global customers and internal stakeholders.
• Strong interpersonal skills; able to work independently as well as collaboratively within a team.
• Self-motivated, efficient, and able to manage multiple priorities simultaneously.

WORKING RELATIONSHIPS

• Report to: Department Manager
• Works with: Biomarker group, in vivo, in vitro group

OUR OFFER

• Competitive remuneration + target bonus + allowance
• 5 days per week (8h working hour)
• Paid annual leave
• Work-Life Balance
• Festival gift and allowance
• Supplemental Medical insurance
• Social insurance and housing insurance

WHY JOIN US?

If you love the intellectual challenge of working in a fast-paced, results-driven organization, there is a home for you at Crown Bioscience. Those who join Crown Bioscience feel a sense of ownership about their future. They thrive through innovation in the foremost fields in biotechnology. Here, you will join passionate professionals who strive to develop innovative products and technologies for biopharmaceutical applications to advance fields in science and medicine. You will excel in an environment characterized by respect, integrity, and growth opportunities.

To find out more about global job opportunity, where you can take a look at your future with Crown Bioscience.

About Crown Bioscience

Crown Bioscience, founded in 2006, is a JSR Corp company. It is headquartered in San Diego, California, with facilities and R&D centers in the US, Europe, and APAC. As a global contract research organization (CRO), it specializes in oncology and immuno-oncology. The company provides preclinical and translational platforms and services to drive drug development and discovery. It offers unique tumor organoid services utilizing HUB technology and has the world’s largest commercially available PDX collection, supported by an extensive biobank of liquid and human biospecimens. It contributed to 6 of the 13 oncology drugs approved by the FDA in 2021. Crown Bioscience helps deliver superior drug candidates to ensure that patients get the right treatment at the right time. For more information, visit: https://www.crownbio.com