Portfolio Operations Manager
Confirmed on the employer's own hiring board on Nov 4, 2026. First seen by Alion on Nov 2, 2026. Genentech scores B on the Alion truth index.
From the beginning, Genentech has been a team of highly dedicated, passionate individuals. We are a place where people are united around a single purpose and an ambitious vision. Together, we aspire to deliver ever better health outcomes for patients while lowering overall healthcare costs. Our goal is to compel the customer to act on behalf of their patients while showing great commitment to the rare disease community, whose support is key. Utilizing innovative methods to identify patients who may benefit from treatment, we must take a highly strategic approach to patient access while assisting patients and their caregivers to navigate the healthcare system.
POSITION SUMMARY
The Portfolio Operations Manager is responsible for the operating system that allows CE to evaluate, prioritize, sequence, and govern enterprise work as one portfolio. This role owns intake of proposed enterprise work, the prioritized CE portfolio roadmap, governance and decision cadence, and the integrated view of dependencies, duplication, capacity, and tradeoffs. The manager partners with CE Leadership, Enterprise Operations, Regions, HEDs, RBO teams, and other stakeholders to ensure the organization focuses resources on the work that matters most and can make transparent portfolio decisions when priorities compete.
SCOPE & KEY RESPONSIBILITIES
Enterprise Portfolio Strategy & Roadmap
- Maintain the integrated CE enterprise portfolio across initiatives, launches, RBO work, and field-partner commitments.
- Translate CE strategy and leadership priorities into a prioritized portfolio roadmap.
- Create visibility to timing, sequencing, interdependencies, and major portfolio milestones.
- Identify duplication, overlap, and opportunities to combine or simplify work across the portfolio.
- Ensure portfolio views are current, decision-oriented, and useful to CE Leadership and operating teams.
Intake, Evaluation & Prioritization
- Own the intake and evaluation process for proposed enterprise work.
- Establish clear criteria for strategic alignment, impact, urgency, effort, capacity, and enterprise value.
- Facilitate prioritization discussions and develop recommendations when demand exceeds available capacity.
- Ensure new work has a clear sponsor, problem statement, intended outcome, and required decision before entering the portfolio.
- Route approved work to the appropriate Enterprise Operations manager, lead, or enabling team for execution.
Portfolio Governance & Decision Support
- Manage the portfolio governance cadence and prepare decision materials for CE Leadership and CELT as needed.
- Create transparent decision logs, escalation paths, and follow-through on portfolio choices.
- Provide concise synthesis of what is changing, why it matters, and what decisions or tradeoffs are required.
- Ensure governance focuses on material decisions, risks, and dependencies rather than routine status reporting.
- Partner with initiative and launch teams to maintain accurate portfolio status and milestone visibility.
Capacity, Dependencies & RBO Integration
- Maintain an integrated view of enterprise capacity, demand, major dependencies, and resource constraints.
- Develop capacity, sequencing, and tradeoff recommendations across competing priorities.
- Integrate RBO work into the broader CE portfolio view so Regional and HED-supported commitments are visible and prioritized.
- Surface cross-portfolio risks and constraints early enough to enable leadership action.
- Partner with Enterprise Initiatives and Launch Operations to resolve conflicts and coordinate shared resources.
Team Leadership & Portfolio Discipline
- Lead, coach, and develop Enterprise Operations Leads assigned to portfolio and RBO work.
- Set standards for portfolio data quality, governance materials, decision support, and milestone tracking.
- Allocate team capacity to the highest-priority portfolio needs and time-sensitive decisions.
- Build strong portfolio management capabilities, tools, and ways of working across the team.
- Contribute to common Enterprise Operations standards, talent practices, and continuous improvement.
KEY DELIVERABLES
- Prioritized CE enterprise portfolio roadmap
- Enterprise intake and evaluation process
- Portfolio governance calendar and decision materials
- Capacity, sequencing, and tradeoff recommendations
- Integrated dependency, risk, and milestone view
- RBO portfolio and commitment visibility
- Executive portfolio dashboards and outcome reviews
- Portfolio standards, templates, and decision logs
MINDSET & CAPABILITIES
- Enterprise thinker who prioritizes the whole over individual workstreams
- Strong judgment on value, urgency, effort, and tradeoffs
- Able to turn complexity into transparent portfolio choices
- Analytical and comfortable synthesizing imperfect information
- Strong facilitator of senior-level prioritization and decision discussions
- Skilled at influencing without formal authority
- Disciplined about governance without creating unnecessary bureaucracy
- Proactive in identifying capacity constraints, dependencies, and duplication
- Strong communication and executive synthesis capabilities
- Collaborative people leader and developer of talent
- Strong drive for results with an enterprise and customer mindset
REQUIRED QUALIFICATIONS
- Bachelor's degree required
- 8-10 years of pharmaceutical, biotechnology, consulting, commercial, portfolio, strategy, program management, and/or operations experience including leading, coaching or mentoring others strongly preferred
- Demonstrated experience with portfolio management, prioritization, governance, or resource planning
- Experience facilitating senior leadership decisions involving competing priorities and tradeoffs
- Strong analytical, synthesis, and project/program management capabilities
- Demonstrated ability to influence across a complex matrixed organization
- Strong communication and executive presentation skills
- Ability and willingness to travel as required for internal and external business meetings
PREFERRED QUALIFICATIONS
- Graduate-level degree (e.g., MBA or advanced life sciences degree)
- Prior commercial operations, portfolio management, strategy, or transformation experience
- Experience supporting large-scale field organizations, RBO, or enterprise planning processes
Location: This position can be based in SSF or Remote. Relocation benefits are not available.
The expected salary range for this position based on the primary location of CA is $142,200 - $264,200 USD Annual. Actual pay will be determined based on experience, qualifications, geographic location, and other job-related factors permitted by law. A discretionary annual bonus may be available based on individual and Company performance. This position also qualifies for the benefits detailed at the link provided below.
Genentech is an equal opportunity employer. It is our policy and practice to employ, promote, and otherwise treat any and all employees and applicants on the basis of merit, qualifications, and competence. The company's policy prohibits unlawful discrimination, including but not limited to, discrimination on the basis of Protected Veteran status, individuals with disabilities status, and consistent with all federal, state, or local laws.
If you have a disability and need an accommodation in relation to the online application process, please contact us by completing this form Accommodations for Applicants.