Salary
≈ $146k – $273k per year (Estimated)
Location
In office (London)
Seniority
Principal
Employment
Full-Time
Overview
Company
Impact
Profile match
Helical is the virtual AI lab for drug discovery. It turns your biology into a frontier discovery system on any model, ranks the candidates worth a program, and improves with every result. Grounded in a therapeutically relevant evaluation, and yours to own.
We’re looking for a Principal Computational Scientist/Director to help translate our foundation models into impactful, real-world discovery workflows. In this role, you’ll provide scientific leadership across model evaluation and applied use cases, ensuring our work stays grounded in the most relevant challenges in drug development and translational research.
You’ll join as a senior individual contributor with leadership and strategy experience at a point where the the team scales. You will act as a key scientific partner to our research team, mentor and support junior colleagues, and work closely with Product and Business Development to turn cutting-edge biology + ML into deliverables that matter for customers.
Requirements
- PhD in Computational Biology, Machine Learning, Bioinformatics, or a related field, with a strong focus on Transcriptomics OR Genomics+ ML, and 2+ years of industry (non-academic) experience OR MSc in a relevant field and 5+ years of industry experience applying ML to Transcriptomics OR Genomics problems
- Strong understanding of ML/AI methods for biological data (e.g., transformers, VAEs, diffusion models, classical ML)
- Hands-on experience with modern ML frameworks such as PyTorch (or equivalent)
- Leadership experience with small teams to work towards defined roadmaps or projects
- Excellent communication skills - able to translate complex science into clear, actionable insights for technical and non-technical stakeholders
- Comfortable in a fast-paced, high-iteration environment, moving quickly from prototype → experiment → insight
- Strong passion for building at the intersection of biology and machine learning
Free account
Stop reading job ads. Get the ones that fit.
One free account turns this page into a shortlist built around your stack, your level and your pay.
Match on every job. Stack, seniority, pay and location, scored against your profile.
657,845 open roles. Read straight off company career pages, refreshed every day.
Unlimited applications. Every one you send is tracked in one place, on-site or on a company board.
3 tailored CVs a month. Rewritten for the exact job you are applying to. Included free.
Free forever. No card. Under a minute.
Your match
How well do you fit this role?
Two answers are enough for a real match. No account needed.
Check my fit
Answers stay in this browser until you create an account.
Recommended for you based on this role
Similar stack
Same company
London
Director, Translational AI & Mechanistic Biology
4 hours ago
≈ $151k – $282k per year (Estimated) • In office • Full-Time • PhD • Cambridge
Python
AI/ML
Fine-tuning
Multimodal AI
AI Agents
PyTorch
LLM
Knowledge Graph
Edge AI
Interpretability
DevOps
GCP
Azure
AWS
Apply
Product Manager – AI Software and Solution
4 hours ago
≈ $194k – $359k per year (Estimated) • Remote/Hybrid • Full-Time • 10+ years exp • Bachelor's Degree • Santa Clara • Hillsboro • Folsom • Austin • Phoenix
Databases
Redis
Milvus
Qdrant
AI/ML
LangChain
AI Agents
PyTorch
RAG
Hugging Face
DevOps
Terraform
Docker Compose
OpenShift
Helm
Docker
Kubernetes
Shift-Left
Vector
Cybersecurity
Shift-Left Security
Apply
Staff Machine Learning Engineer - Search Ranking
4 hours ago
$152k – $277k per year • In office • 4+ years exp • Bachelor's Degree • Mountain View
Python
Java
Databases
Google BigQuery
BigQuery
AI/ML
Spark
Airflow
MLFlow
XGBoost
Vertex AI
Embeddings
Scikit-learn
Multimodal AI
Kubeflow
TensorFlow
Keras
PyTorch
Contrastive Learning
Amazon SageMaker
DevOps
GCP
AWS
Vector
Apply
Software Engineer, Robotics - Isaac Lab
4 hours ago
≈ $31k – $81k per year (Estimated) • In office • Full-Time • 3+ years exp • Bachelor's Degree • Shanghai
AI/ML
Reinforcement Learning
TensorFlow
PyTorch
DevOps
GitHub
Robotics
Isaac Gym
Isaac Sim
MuJoCo
Isaac Lab
Motion Planning
Imitation Learning
Reinforcement Learning
Apply
≈ $17k – $31k per year (Estimated) • In office • Internship • Master's Degree • Shanghai
Python
C++
C++
TensorFlow C++
PyTorch C++
AI/ML
Reinforcement Learning
JAX
Computer Vision
TensorFlow
PyTorch
Synthetic Data
Physical AI
Robotics
Isaac Sim
MuJoCo
Isaac Lab
Imitation Learning
Reinforcement Learning
Apply
Software Developer - Biology
3 hours ago
≈ $82k – $198k per year (Estimated) • In office • Full-Time • Master's Degree • London
Python
AI/ML
SciPy
DevOps
GCP
Azure
CI/CD
Git
AWS
Docker
QA
Pytest
Apply
Senior Account Executive
3 months ago
≈ $85k – $231k per year (Estimated) • Remote/Hybrid • Full-Time • London
Apply
Platform Engineer
5 months ago
≈ $70k – $177k per year (Estimated) • In office • Full-Time • Master's Degree • London
Python
AI/ML
MLFlow
DevOps
GCP
Azure
CI/CD
AWS
Docker
Kubernetes
Cybersecurity
SOC 2
HIPAA
Apply
Apply
Finance - Fund and Investment Operations
6 hours ago
≈ $41k – $96k per year (Estimated) • Remote/Hybrid • Full-Time • London
Apply
Associate Financial Analyst/Trader
7 hours ago
$70k – $117k per year • In office • Full-Time • 2+ years exp • London
Apply
Management Consulting Manager - Banking
7 hours ago
In office • Full-Time • London • Manchester • Edinburgh
Management
Agile
Apply
AI Transformation & Process Excellence Manager
7 hours ago
≈ $42k – $84k per year (Estimated) • In office • Full-Time • Bachelor's Degree • London
AI/ML
AI Agents
Robotics
Digital Twin
Apply
Director, CRM DU Strategy & Engagement (80-100%)
7 hours ago
≈ $128k – $261k per year (Estimated) • Remote/Hybrid • Full-Time • Master's Degree • Basel • London • Dublin • Hanover
Management
SharePoint
Apply
This is one of many
657,845 more open roles from verified company boards, updated every day.

