Manager, Portfolio Strategy & Forecasting
Confirmed on the employer's own hiring board on Nov 14, 2026. First seen by Alion on Sep 24, 2026. Kardigan scores A on the Alion truth index.
About Us
Kardigan is a heart health company working to make cardiovascular disease preventable, curable and no longer the leading cause of death in the world.
It is Kardigan’s mission to develop multiple targeted treatments in parallel that bring people with cardiovascular diseases to the cures they deserve.
Led by Tassos Gianakakos, Jay Edelberg, M.D., Ph.D.,and Bob McDowell, Ph.D., Kardigan’s co-founders have reunited after leading MyoKardia to discover and develop mavacamten, the first cardiac myosin inhibitor, resulting in an acquisition by Bristol Myers Squibb in 2020.
We have a cutting-edge discovery and translational research platform, a pipeline of late-stage candidates, and an industry-leading team that is driven to improve the lives of patients.
At Kardigan, we are motivated by our values which guide how we work, interact, and achieve our goals. Driven by patients and their families, we are deeply committed to improving the lives of patients and prioritizing their needs above all else. We believe in being authentic -leading with truth to bring out the best in others by creating an environment where every person knows they will be fully accepted. With an eagerness to learn, we encourage the highest levels of curiosity and are open to changing our minds. We are committed to winning as a team with urgency, excellence, and intention, and support each other no matter what role we play or where we sit. Lastly, we strive to enable the impossible because patients are counting on us. We are not afraid to take risks to unlock innovation and advance scientific discoveries.
These values are the foundation of our work, empowering us to make a real difference, every day.
Position Title: Manager, Portfolio Strategy & Forecasting
Department: Portfolio Strategy
Reports To: Director, Portfolio Strategy
Location: Evanston, IL - On-site 4 days per week (Mon to Thurs)
Job Overview
Kardiganis hiring a Manager, Portfolio Strategy & Forecastingto turn data into the insights that guide strategic and operational decisions across our portfolio. Sitting within the Portfolio Strategy team, you will ownhow patient andrevenue forecastsget built, synthesized and communicated, and serve as a strategic thought partner to leaders making portfolio investment decisions.This role will help teams develop forecasts and translate them into portfolio-level strategic choices(e.g., indicationsequencing andexpansion, NPV analysis, lifecycle management).You will work hand-in-handwith the Insights & Analytics team, shaping the primary and secondary market research questions across patients, physicians, and payersso the right inputs feed the forecast. The role partners broadly across the organization, including Corporate Strategy, Product Strategy, Commercial, Clinical Development, Medical Affairs, Regulatory, R&D, Program Management and Business Development.Success here depends on analytical rigorpaired with strategic judgment: framing ambiguous questions, pressure-testing the underlying data, and reconciling signals that arrive from very differentsources. The position also requires businessacumen and a deep understanding of pharmaceutical operations to ensure the successful development, launchand growth of our products. The position is based in Evanston, IL.
Essential Duties and Responsibilities
- Bachelor’s degree required and a minimum of 5 years of consulting, investment, marketing, forecasting, or agency experience in healthcare/biopharmaceuticals. MBA or advanced degree preferred.
- Forecasting and Modeling: Proficiency in data analysis and financial modeling, including forecast, valuation and scenario models.
- Data and Market Research: Experience conducting and/or evaluating secondary data sources and primary market research, with the ability to interpret complex scientific and market data, identify key trends and extract meaningful insights.
- Collaboration: Ability to effectively collaborate across multiple functions and with internal and external stakeholders of various backgrounds and skill sets. Skilled in establishing a collaborative and respectful environment.
- Communication: Writes and presents with clarity, and can make a complex analysis land with scientists, commercial leaders, and executives alike.
- Industry Knowledge: Deep familiarity with the healthcare landscape - managed care and payers, patients, providers, biopharma companies, and the technologies and disease-area trends reshaping them. Cardiovascular or cardiometabolic experience is a plus.
- Strategic Thinking: Strong strategic thinking with the ability to synthesize market data, customer insights and scientific information into actionable recommendations; comfortable influencing executive-level decisions and connecting analysis to enterprise strategy.
- Business Excellence: Strong project and process management skills including the ability to manage multiple projects, set priorities and meet deadlines.
- Critical Thinking: Strong critical thinking and structured, problem-solving skills.
- Agility: Comfortable operating in a fast-moving, often ambiguous environment, and adapts as priorities shift.
Exact Compensation may vary based on skills, experience and location.
Pay range
$142,000—$185,000 USD