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Salary
$131k – $192k per year
Location
Hybrid (South San Francisco, United States)
Seniority
Staff · 8+ years exp
Visa
H-1B filings in 12 months: 15 · for this role: 2 · green card filings: 5

Confirmed on the employer's own hiring board on Oct 21, 2026. First seen by Alion on Oct 20, 2026. Twist Bioscience scores B on the Alion truth index.

Overview
Company
Impact
Profile match
Twist Bioscience is a synthetic biology company headquartered in South San Francisco, California that manufactures synthetic DNA on a silicon-based platform. Founded in 2013 and listed on Nasdaq, it sells genes, oligo pools, NGS target enrichment panels and library preparation kits, variant libraries and antibody discovery services to researchers in pharma, biotech, diagnostics and academia, with production in South San Francisco and Wilsonville, Oregon and teams in Quincy, Massachusetts, Carlsbad and Asia. It hires manufacturing associates, automation and systems engineers, scientists, bioinformatics specialists, and sales and business development staff.

Master Data Governance Office Lead (Hybrid in South San Francisco, CA)

Summary

Reporting directly to the Director of Business Intelligence, the SAP Master Data

Governance (MDG) Lead will provide business processes expertise to the end-to-end

architecture, implementation, and operational strategy of our enterprise master data ecosystem.

In this role, you will bridge technical execution, analytics strategy and business

process-helping to implement the SAP MDG platform, creating data quality rules, and initially

establishing a SAP Data Governance Office to ensure high data integrity, seamless reporting,

and single-source-of-truth analytics across the organization.

Key Responsibilities

SAP MDG Build & Technical Architecture

  • Participate and add expertise to the end-to-end implementation and configuration

    of SAP MDG domains (Business Partner, Customer/Vendor, Material, at a later

    time Financials).

  • Design custom data models, UI floorplans (FPM), change request workflows

    (BRF+), and Data Replication Frameworks (DRF).

  • Partner with BI and enterprise architecture teams to integrate MDG with SAP

    S/4HANA, analytics platforms, data warehouses, and downstream legacy

    systems.

Rule Creation & Data Quality Management

  • Define and enforce data validation rules, duplicate check algorithms, and

    business logic within the SAP MDG platform.

  • Establish automated data profiling, continuous remediation processes, and data

    quality scoring across core master data domains.

  • Define and monitor data governance KPIs, completion cycle times, and data

    health dashboards in alignment with reporting goals.

Governance Office & Stewardship Leadership

  • Build and formalize the Enterprise Data Governance Office, defining its charter,

    operating model, and cross-functional council.

  • Establish enterprise data stewardship frameworks, defining clear roles (Data

    Owners, Stewards, Custodians) and approval matrices.

  • Author data policies, standard operating procedures (SOPs), data dictionary

    standards, and data lineage documentation.

  • Partner with the Director of Business Intelligence to align data governance

    frameworks with business reporting, analytics strategy, and regulatory

    compliance.

Qualifications & Requirements

  • Bachelor’s degree in Computer Science, Information Systems, Business Intelligence, or a related field.
  • 8+ years Experience in SAP Data Management, with 4+ years leading full-lifecycle SAP MDG implementations.
  • Proven track record in both direct and indirect management.
  • Successful collaboration experience is a must.
  • Proven track record of establishing and managing a Data Governance Office and operationalizing data stewardship models.
  • Solid understanding of how master data governance directly impacts BI reporting, data warehousing, and enterprise analytics.

About Twist Bioscience

Twist Bioscience synthesizes genes from scratch, known as “writing” DNA. Just as children learn to both read and write, the next phase of development for the genomics revolution is the ability to write DNA.

At Twist Bioscience, we work in service of people who are changing the world for the better. In fields such as health care, agriculture, industrial chemicals and data storage, our unique silicon-based DNA Synthesis Platform provides precision at a scale that is otherwise unavailable to our customers.

Twist Bioscience Corporation is an Equal Opportunity Employer. Twist Bioscience Corporation provides equal employment opportunities to all employees and applicants for employment without regard to race, color, religion, sex, sexual orientation, gender identity, national origin, age, disability, genetic characteristics, or any other category protected by law.

The base cash compensation for this California-based role is below. In addition to base salary, this role is eligible for bonus, equity, and a generous benefits package. Final compensationamounts are determined by multiple factors, including candidate skill, experience, expertise, and location and may vary from the amount listed above. Compensationmay be different in other locations.

San Francisco Bay Area Pay Range

$130,678—$192,178 USD

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