Profluent
profluent.bio
Actively hiring
Biotechnology
Cell & Gene Therapy
As featured in
View 8 jobs
Follow
Overview
News
Technologies
Salaries
Products
People
Growth
Offices
Jobs
Financials
Funding and backers
Total raised
$149M
3 rounds on record
Latest round
$106M
Venture round · Nov 2025 · 10 mo ago
Team
51-200
employees, estimated range
Hiring now
15
+6 posted in 30 days
Backers
4
Airstreet, AIX Ventures
The money's age
Fresh money
10 months since the last round · and hiring
Momentum
36/100
hiring for its size, fresh money
Last sign of life
this month
a posting or a news item
The story so fareach stage dated by its source: the company's releases, the press, registers, filings
Dec 9, 2025
Partnership December 9, 2025 Profluent Bio Announces Strategic Collaboration with Ensoma to Develop AI-Designed Base Editors for In Vivo Hematopoietic Stem Cell… · businesswire.com
Nov 21, 2025
Raised a round Venture round $106M · SiliconANGLE
Oct 6, 2025
Partnership October 6, 2025 Profluent Announces Multi-Year Collaboration with Corteva to Accelerate Sustainable, AI-Powered Crop Innovation Announcement · businesswire.com
Sep 22, 2025
Partnership Revvity and Profluent Collaborate to Launch AI-Enhanced Adenine Deaminase Pin-point Base Editing Systems · businesswire.com
Apr 16, 2025
Launched April 16, 2025 Profluent Introduces ProGen3, Demonstrating Scaling Laws for Foundation Models in Writing Biology Announcement · businesswire.com
Jan 7, 2025
Launched January 7, 2025 Profluent debuts AI model for CRISPR design, hoping to expand gene editing's potential Press · endpts.com
Mar 23, 2024
Raised a round Venture round $35M · led by Spark Capital · Pulse 2.0
Jan 30, 2023
Launched Profluent debuts to design proteins with machine learning · endpts.com
Aug 19, 2022
Raised a round Venture round $8M · SEC Form D
2022
Founded
Tractionpublic signals, read monthly
Web presence
top 2%
of 133.2M domains by links, Common Crawl
Hacker News stories
3
best: 1 points
Funding rounds
| Round | Date | Amount | Investors | Source |
|---|---|---|---|---|
| Venture round | Nov 2025 | $106M | — | SiliconANGLE |
| Venture round | Mar 2024 | $35M | Spark Capital lead, Insight Partners, Salesforce Ventures, Octant | Pulse 2.0 |
| Venture round | Aug 2022 | $8M | — | SEC Form D |
Registers and programsofficial lists and records that name the company
| Legal entity | Profluent Bio Inc. | SEC Form D |
Founders and leadersfrom filings, registers and the company's site
Ali MadaniExecutive Officer, DirectorSEC Form D
Backed byfrom the funds' portfolios and accelerator catalogs
Airstreet 
AIX Ventures 
Insight Partners 
Spark Capital Investors in similar startupsfunds that back the companies most like this one
Similar startupsby what they do, their industry and backers
GeneVentiv Therapeutics — advancing gene therapy approaches.
Sabai exclusively focuses on ethical and biosafety reviews and support that leads with science and differentiates with service.
The RNA covalency company. Endura's small molecule drugs form an enduring bond with an mRNA, blocking translation and knocking down…
Capsida Biotherapeutics is an industry-leading gene therapy platform company creating a new class of targeted, non-invasive gene therapies…
Stately Bio is developing the next generation of life-saving regenerative medicines with the world.
ProtaGene is a world-leading CRO partner for the biopharmaceutical and gene and cell therapy industries.
How Profluent hires
Truth index
A 90/100
Median time to fill
96 days
Ghost roles
0%
Stale roles
18%
Reposted roles
0%
Profluent scores A on the Alion truth index (A is best, E worst), measured over 11 open roles re-checked against its own hiring board: 0% look like ghost listings, 18% have gone stale and 0% are the same role posted again. Its roles close in a median of 96 days. It measures how much of what this employer publishes turns into a real, finite search - not the employer as a workplace. How the index is computed
Overview
Profluent is a company founded in 2022 that trains large language models on protein sequences to design new functional proteins. It released OpenCRISPR-1, a gene editor designed entirely by a model and made freely available for ethical research and commercial use. The company works on editors, antibodies and enzymes that have no direct natural counterpart.
News
GEMMABio Awarded ARPA-H Funding to Pursue Innovative Base-editing Strategy for Rare Liver Diseases
- The goals of this project will be enabled through a partnership with Profluent Bio who will deploy its frontier AI models and its scalable base editor...
Read more
Report
Lilly, AI biotech Profluent ink $2.25B pact in search of genetic medicine 'holy grail'
Weight loss giant Eli Lilly has penned a DNA editing deal with Profluent Bio, continuing its dealmaking spree as well as its commitment to artificial intelligence.
Read more
Report
Profluent, Lilly partner in genetic medicine deal worth up to $2.25 billion
At Yahoo Finance, you get free stock quotes, up-to-date news, portfolio management resources, international market data, social interaction and mortgage rates that help you manage your financial life.
Read more
Report
Eli Lilly enlists AI startup for next-generation gene editors
Eli Lilly deal with Profluent aims to go beyond CRISPR by using AI-designed enzymes to insert entire genes. If it works, it could reshape genetic medicine.
Read more
Report
AI start-up Profluent nabs Lilly as first big pharma partner
AI start-up Profluent has signed a major alliance with pharma group Eli Lilly, worth up to $2.25bn, that will focus on gene-editing therapies.
Read more
Report
Report
December 9, 2025 Profluent Bio Announces Strategic Collaboration with Ensoma to Develop AI-Designed Base Editors for In Vivo Hematopoietic Stem Cell Therapies Announcement
Read more
Report
Profluent Bio raises $106M from Jeff Bezos and others to accelerate protein design with AI
Profluent Bio raises $106M from Jeff Bezos and others to accelerate protein design with AI - SiliconANGLE
Read more
Report
Report
Show more news
Tech stack
Technologies named in job postings at Profluent over the last 12 months, by layer, with the share of postings for each.
Technologies in use
34
Postings analysed
14
Stack modernity
71/100
Languages
Python43%
SQL7%
PowerShell7%
Frameworks & libraries
PyTorch36%
CUDA7%
FSDP7%
NumPy7%
Databases
BigQuery7%
Google BigQuery7%
PostgreSQL7%
Cloud & platforms
GCP43%
Spark43%
AWS29%
Azure29%
Sign in to see how your skills match this stack
Sign In
Full Profluent tech stack
34 technologies · by team · pay by technology · changes · similar stacks
Salary insights
Compensation ranges based on this company's open jobs
Median
$246k
Typical range
$110k – $355k
Open positions
13
11
Jobs
Junior
9.1%
Middle
18.2%
Senior
36.4%
Staff
9.1%
Architect
27.3%
| Level | Jobs | Median | Typical range |
|---|---|---|---|
| Junior | 1 | $167k | $167k |
| Middle | 2 | $250k | $160k – $339k |
| Senior | 4 | $193k | $110k – $339k |
| Staff | 1 | $246k | $246k |
| Architect | 3 | $340k | $207k – $355k |
Highest paying role
Director, Software and Data Engineering
$355k
Normalized to USD per year
All salaries at Profluent
By role, level and city, against the market · 13 jobs with pay
People
Ali Madani
Executive Officer, Director
Dylan Morris
Director
Names and roles come from public filings, company registers and the company's own site. Is this you? Correct or remove · How we handle this data
Growth
Hiring Momentum
69/100
Growing
Open positions
15
5 opened / 2 closed in 30 days
Median time-to-fill
96 days
faster than 14% of the market
ATS activity
Every ~4 hours
Today
Hiring Dynamics
+100%
Hiring Focus
The percentage next to each role is its share of the company's job openings over the last 90 days; the arrow shows the shift versus the previous period.
Science & Research
36% ▲
AI/ML
18% ▼
Early Careers
18% ▲
Support
9% ▲
Design
9% ▲
Finance
9% ▼
Activity Timeline
Added NumPy to stack
Oct 2026
Added Webflow to stack
Oct 2026
Added Notion to stack
Oct 2026
Added Figma to stack
Oct 2026
Added Airtable to stack
Oct 2026
Added Windows to stack
Sep 2026
Added VPN to stack
Sep 2026
Added VLAN to stack
Sep 2026
Added Microsoft Office to stack
Sep 2026
Added DLP to stack
Sep 2026
Added Machine Learning to stack
Sep 2026
Added Slack to stack
Sep 2026
Offices
Where the company hires and what each office is for
Cities
2
Hiring now
1
Countries
1
Busiest office
Emeryville
Loading the map
Headquarters
Builds here
Office with open vacancies
No open vacancies right now Tap a pin for the office
Berkeley
United States
HQ
Emeryville
United States
Regional office
Emeryville, CA
15 open roles 11 posted in 90 days 60% engineering 7% remote 50-200 est. staff $256k Avg Salary
hires for Science & Research, AI/ML, Leadership
Jobs
$157k – $207k per year • Remote (United States) • Emeryville
Figma
Webflow
Management
Slack
Notion
Airtable
Google Workspace
Apply
$167k – $206k per year • Hybrid • 2+ years exp • Emeryville
PowerShell
GCP
Windows
VPN
VLAN
Cybersecurity
SentinelOne
SOC 2
DLP
Management
Slack
Jira
Google Workspace
Gmail
Microsoft Office
Apply
$212k – $339k per year • Hybrid • 5+ years exp • Bachelor's Degree • Emeryville
MLFlow
PyTorch
Machine Learning
DevOps
CI/CD
Apply
$212k – $339k per year • Hybrid • PhD • Emeryville
Reinforcement Learning
PyTorch
Post-training
Machine Learning
DevOps
GCP
Azure
AWS
Apply
$212k – $339k per year • Hybrid • PhD • Emeryville
PyTorch
Pre-training
Machine Learning
DevOps
GCP
Azure
AWS
Apply
$212k – $339k per year • Hybrid • 3+ years exp • PhD • Emeryville
PyTorch
Machine Learning
DevOps
GCP
Azure
AWS
Apply
$205k – $246k per year • Hybrid • 7+ years exp • Master's Degree • Emeryville
Python
SQL
Spark
Apply
$268k – $355k per year • Hybrid • 8+ years exp • Bachelor's Degree • Emeryville
Python
Spark
Machine Learning
Apply