2,074,683open jobs
123,097companies
251,930added this week
Browse all
Salary
≈ $182k – $339k per year (Estimated)
Location
In office (San Mateo)
Seniority
Staff · 5+ years exp
Employment
Full-Time

Confirmed on the employer's own hiring board on Oct 31, 2026. First seen by Alion on Mar 11, 2026. Autoscience scores B on the Alion truth index.

Overview
Company
Impact
Profile match
Autoscience, which also calls itself the Autoscience Institute, creates AI systems that autonomously conduct AI research and train models for frontier and applied AI labs. It announced an AI agent that created literature accepted at ICLR 2025 workshops and hires machine learning research scientists and software engineers. The company is headquartered in San Mateo, California, United States.

Company Description

At Autoscience Institute, we automate AI research. Recently, we announced the first AI agent to autonomously create peer-reviewed literature (ICLR 2025) and the first AI system to win a Kaggle medal. We are passionate about pushing the boundaries of artificial intelligence and contributing to groundbreaking advancements in the field.

Role Description

This is a full-time on-site role for a Senior or Staff Software Engineer (Technical Lead) located in the San Francisco Bay Area.

In this role, you will lead the design and development of core systems that power autonomous research agents. You’ll be responsible for building reliable backend infrastructure and production systems that support large-scale AI experimentation and research workflows.

We are looking for engineers who have owned complex projects end-to-end, contributed to system architecture, and helped guide small teams of engineers through delivery. You should be comfortable writing high-quality code, producing clear design documents, and making thoughtful technical decisions that shape how systems evolve over time.

You will work closely with both engineers and researchers to translate experimental ideas into robust production systems.

Responsibilities

  • Lead the design and implementation of core backend and infrastructure systems

  • Own projects from architecture and design through production deployment

  • Write clear technical design documents and drive engineering decisions

  • Build and maintain 24/7 production systems supporting autonomous research agents

  • Partner closely with research teams to productionize experimental workflows

  • Guide and collaborate with engineers on system design and implementation

  • Improve system reliability, scalability, and observability

  • Help shape the technical direction of the platform

Qualifications

  • Experience leading complex engineering projects or technical initiatives

  • Experience acting as a technical lead or guiding small teams of engineers

  • Strong software design and architecture skills

  • Demonstrable experience writing clear technical design documents

  • Strong experience with Python

  • Experience building or operating backend or production infrastructure

  • Experience working in 24/7 production environments

  • Experience with Google Cloud Platform (GCP) or similar cloud infrastructure

  • Strong understanding of software evolution, maintainability, and system design tradeoffs

  • Ability to collaborate effectively with both engineers and researchers

  • Bachelor’s degree in Computer Science, Mathematics, or a related field

  • Strong candidates will typically have 5+ years of experience building and operating production software systems, including ownership of projects from design through deployment

Benefits & Perks

  • Our comp is competitive against major LLM frontier lab packages

  • Unlimited PTO and flexible working arrangements

  • Conference attendance and publication support

Our Culture

We're a team of passionate researchers and engineers working to automate scientific discovery. We believe in the power of AI to accelerate scientific discovery and are committed to responsible AI development.

Free account
Stop reading job ads. Get the ones that fit.
One free account turns this page into a shortlist built around your stack, your level and your pay.
Match on every job. Stack, seniority, pay and location, scored against your profile.
2,074,683 open roles. Read straight off company career pages, refreshed every day.
Unlimited applications. Every one you send is tracked in one place, on-site or on a company board.
3 tailored CVs a month. Rewritten for the exact job you are applying to. Included free.
Create a free account Continue with Google
Free forever. No card. Under a minute.

Your match

How well do you fit this role?
Two answers are enough for a real match. No account needed.
Check my fit
Answers stay in this browser until you create an account.

Recommended for you based on this role

Backend
Similar stack
Same company
San Mateo
$138k – $216k per year · In office · Full-Time · 3+ years exp · Bachelor's Degree · Hoboken
Python
Java
Databases
ElasticSearch
AI/ML
Spark
DevOps
Rest API
Analytics
ETL/ELT
Management
Agile
Apply
$90k – $180k per year · In office · Full-Time · 3+ years exp · Bachelor's Degree · Bentonville
Python
JavaScript
Java
C#
Java
Spring Boot
Databases
MySQL
Cassandra
RabbitMQ
MS SQL
Apache Kafka
DevOps
Rest API
Istio
Azure
CI/CD
Jenkins
Docker
Kubernetes
Service Mesh
Cybersecurity
SonarQube
Management
Monday.com
Agile
QA
Swagger
Apply
$110k – $220k per year · In office · Full-Time · 4+ years exp · Bachelor's Degree · Bentonville
JavaScript
Java
Kotlin
Node JS
Java
Maven
Spring Boot
Databases
Apache Kafka
Frontend
Next.js
React.js
DevOps
Rest API
Istio
Kibana
Prometheus
CI/CD
Docker
Kubernetes
Grafana
GitHub
MedTech
FHIR
Apply
$129k – $220k per year · In office · Full-Time · 6+ years exp · Bachelor's Degree · Bentonville
Python
JavaScript
C#
C#
.NET
Mobile
MVP
DevOps
Azure
CI/CD
AWS
Management
Monday.com
Jira
Agile
QA
Selenium
Apply
$110k – $220k per year · In office · Full-Time · 4+ years exp · Bachelor's Degree · Bentonville
Python
JavaScript
Java
Rust
TypeScript
C++
Java
Spring MVC
Databases
ActiveMQ
Apache Kafka
AI/ML
Copilot
AI Agents
Feature Store
DevOps
Rest API
CI/CD
AWS
Docker
Kubernetes
Platform Engineering
QA
Cucumber
JMeter
Apply
In office · Bachelor's Degree · Sandton
Python
SQL
C#
Databases
Databricks
AI/ML
Function Calling
AI Agents
RAG
Human-in-the-Loop
Structured Outputs
Agentic Workflows
DevOps
Rest API
Azure
Analytics
ETL/ELT
Azure Data Factory
Management
Power Automate
Apply
Senior SDE 6 days ago
≈ $17k – $39k per year (Estimated) · In office · 5+ years exp · Hyderabad
Python
JavaScript
TypeScript
C#
Databases
PostgreSQL
AI/ML
LangChain
Model Context Protocol
Fine-tuning
AI Agents
RAG
Hugging Face
LLMOps
A2A
Context Engineering
Frontend
React.js
Mobile
Clean Architecture
DevOps
Azure
AWS
Kubernetes
Amazon EKS
Amazon S3
Management
Agile
Apply
≈ $8.5k – $23k per year (Estimated) · In office · 1+ year exp · Bengaluru
Python
SQL
Python
Flask
FastAPI
Django
Celery
Databases
MySQL
Redis
Apache Kafka
DevOps
Rest API
GCP
CI/CD
Git
AWS
Docker
Kubernetes
QA
Postman
Pytest
Apply
≈ $45k – $95k per year (Estimated) · In office · TS/SCI · 3+ years exp · Quantico
Python
SPSS
Analytics
Microsoft Excel
Apply
$40k per year · In office · Internship · Bachelor's Degree · Tampa
Python
JavaScript
TypeScript
SQL
C#
AI/ML
Copilot
Claude
ChatGPT
DevOps
Git
Management
Agile
Scrum
Apply
Software Engineer 1 year ago
≈ $134k – $290k per year (Estimated) · In office · Full-Time · Bachelor's Degree · San Mateo
Python
AI/ML
AI Agents
LLM
Machine Learning
DevOps
GCP
Management
Agile
Apply
≈ $126k – $282k per year (Estimated) · In office · Full-Time · San Mateo
Python
AI/ML
AI Agents
LLM
Machine Learning
Apply
≈ $88k – $228k per year (Estimated) · In office · Full-Time · San Mateo
AI/ML
AI Agents
LLM
Machine Learning
Management
Agile
Apply
≈ $153k – $341k per year (Estimated) · In office · Full-Time · PhD · San Mateo
AI/ML
Reinforcement Learning
AI Agents
LLM
RAG
Multi-Agent Systems
Machine Learning
Apply
$153k – $197k per year · Equity · Hybrid · 1+ year exp · San Mateo
JavaScript
TypeScript
Frontend
React.js
Analytics
A/B Testing
Apply
$197k – $243k per year · Equity · Hybrid · PhD · San Mateo
Python
SQL
AI/ML
Spark
AI Agents
Machine Learning
Apply
$48k – $56k per year · In office · San Mateo
Apply
$48k – $54k per year · In office · Full-Time · 1+ year exp · San Mateo
Apply
$294k – $343k per year · Equity · Hybrid · 8+ years exp · San Mateo
C++
DevOps
Linux
Apply
See all jobs
This is one of many
2,074,683 more open roles from verified company boards, updated every day.