Human Resources Generalist

Job Title: Human Resources Generalist

Location: San Diego

Job Type: Full-Time

Who We Are

Avenzo Therapeutics, Inc. (“Avenzo ” or “ Company ”) is a clinical-stage biotechnology Company focused on developing next-generation oncology therapies for patients. The Company was co-founded in 2022 by Drs. Athena Countouriotis and Mohammad Hirmand (former CEO and CMO of Turning Point Therapeutics, Inc., respectively). Our team is passionate about and committed to advancing a pipeline of potentially differentiated targeted oncology programs that make a difference in the lives of people with cancer. The Company is headquartered in San Diego, California.

Position Summary

Reporting to the Chief Human Resources Officer, the Human Resources Generalist will play a key role in supporting employee lifecycle activities and delivering high-quality HR services across the Company. This position is responsible for talent acquisition coordination, onboarding and offboarding, HR operations, employee relations, compliance, HRIS administration, talent management programs, and employee experience initiatives. The ideal candidate is a highly organized, service-oriented professional who thrives in a fast-paced environment and partners effectively across functions to enhance operational excellence, compliance, and the employee experience.

Essential Job Functions and Responsibilities

• Support full-cycle recruitment activities, including job postings, candidate sourcing, interview scheduling, applicant tracking, offer preparation, and background checks
• Partner with hiring managers to deliver a seamless and positive recruitment experience
• Administer onboarding and offboarding processes, including new hire orientation, employment documentation, system access coordination, employee changes, and separation activities
• Maintain accurate employee lifecycle records, including recruitment, onboarding, personnel files, and HRIS data, ensuring data integrity, confidentiality, and compliance
• Process employee lifecycle transactions, including promotions, transfers, compensation changes, leaves of absence, and terminations
• Administer employment verifications, unemployment claims, and other HR operational processes
• Support leave administration, workplace investigations, and the interpretation and application of HR policies
• Partner with payroll on the entry of employee compensation, status, and organizational changes to support accurate and timely payroll processing
• Administer employee benefit enrollments and plan changes, and respond to benefits-related inquiries
• Coordinate companywide compliance training, monitor completion status, and maintain accurate training records
• Assist with HR audits, regulatory reporting, compliance initiatives, and documentation requests
• Support talent management programs, including performance management, talent reviews, career development, and related initiatives
• Generate HR reports, organizational charts, and workforce data to support business and HR decision-making
• Identify opportunities to improve HR processes and enhance operational efficiency and the employee experience
• Participate in HR initiatives, organizational change efforts, special projects, and continuous improvement activities as assigned

Preferred Qualifications

• Bachelor’s degree in Human Resources or Business Administration required, or a related area degree preferred, with 5+ years of progressive Human Resources experience as a generalist, of experience in the life sciences industry or an equivalent combination of academic and industry experience
• Strong knowledge of federal, state, and local employment laws and HR compliance requirements
• Demonstrated experience supporting recruiting, onboarding, offboarding, employee relations, administration, performance management, talent management, and benefits
• Proficiency with HRIS platforms and systems; experience with applicant tracking, payroll, learning management, and performance management systems preferred
• Demonstrated ability to maintain confidentiality and exercise sound judgment when handling sensitive employee and business information
• Strong organizational and project management skills, with the ability to manage multiple priorities and deadlines in a dynamic environment
• Advanced proficiency in Microsoft Office applications, including Excel, PowerPoint, Word, and Outlook
• Proven ability to work independently while collaborating effectively within a cross-functional, team-oriented environment
• Experience supporting organizational change initiatives, process improvements, and HR-related projects
• Excellent communication and interpersonal skills, with the ability to collaborate effectively with internal and external stakeholders
• Strong analytical and problem-solving abilities, with a strategic mindset

Physical Demands and Work Environment

Physical Demands:

• Constant or continuous use of a computer keyboard, monitor, and mouse to perform a variety of tasks
• Constant or frequent sitting, standing, or walking
• May lift and/or move objects of various weights

Work Environment:

• On-site requirement (Monday through Thursday)
• Noise level in the work environment is usually moderate
• Fast-paced, time sensitive environment with frequently changing priorities
• Handle multiple projects simultaneously

Reasonable accommodations may be provided to enable qualified individuals with disabilities to perform the essential functions of the position.

Salary Range

The salary range for this position is $105,000 to $113,000 per year. The final pay offered to a successful candidate will be dependent on several factors that may include, but are not limited to, the type and years of experience within the job and the industry, education, and skills and certifications.

Benefits

Provided they meet all eligibility requirements under the applicable plan documents, employees (and their eligible dependents) will be eligible to enroll in group healthcare plans that offer medical, dental, vision, and basic life and AD&D insurance. Additional benefit programs include short-term and long-term disability insurance, flexible spending accounts, health savings accounts, and voluntary insurance programs, including voluntary life, AD&D accident, and critical illness. Employees will also be able to enroll in the Company’s 401(k) plan. In addition, employees will accrue 10 hours of paid vacation time every month and accrue 1 hour of paid sick leave for every 30 hours worked. Employees also enjoy 17 paid holidays each calendar year, including a winter closure, subject to applicable Company policies. All benefits are subject to the terms and conditions of the applicable plan documents and Company policies, which may be amended from time to time.

Other Compensation

The hired candidate will be eligible to receive an annual discretionary bonus and an equity award, subject to the terms of the applicable employment agreement, plan documents, and Company policies.

The information above is intended to provide a general description of benefits and other compensation and is not a substitute for applicable plan documents or company policies.

Applications for this position are anticipated to close on September 15, 2026. For more information about this posting, please contact [email protected].

Equal Employment Opportunity

Avenzo is committed to providing equal employment opportunities to all employees and applicants without regard to an individual’s actual or perceived protected characteristic or characteristics, or any combination of protected characteristics including race (including traits associated with race, such as hair texture and protective hairstyles, including braids, locks, and twists), ethnicity, religion, religious creed (including religious dress and grooming practices), color, sex (including childbirth, breast feeding, and related medical conditions), gender, gender identity or expression, sexual orientation, national origin, ancestry, citizenship status, uniformed service member and veteran status, marital status, pregnancy, age (40 and over), protected medical condition (including cancer and genetic conditions), genetic information, disability (mental and physical), reproductive health decision-making, medical leave or other types of protected leave (requesting or approved for leave under the Family and Medical Leave Act or the California Family Rights Act), the employee or their family member’s status as a victim of a qualifying act of violence, political activity or affiliation, use of cannabis off the job and away from the workplace, association with an individual who has, or is perceived to have, a protected characteristic or characteristics, or any combination of protected characteristics, or any other protected status in accordance with all applicable federal, state, and local laws.

Notice to Search Firms/Third Party Agencies

Avenzo does not accept unsolicited resumes from recruiters, employment agencies or search firms without a valid, executed search agreement in place.