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Salary
$190k – $240k per year
Location
In office (Alameda)
Seniority
Staff · 7+ years exp
Visa
H-1B filings in 12 months: 33 · for this role: 4 · green card filings: 10
Employment
Full-Time

Confirmed on the employer's own hiring board on Nov 6, 2026. First seen by Alion on Nov 5, 2026.

Overview
Company
Impact
Profile match
Exelixis is an American oncology-focused biotechnology company headquartered in Alameda, California, that discovers, develops and commercializes small-molecule cancer medicines. Operating in the biotech sector for about 25 years, it built a commercial foundation on its lead cancer product and reinvests that revenue in drug discovery, clinical development and a pipeline of investigational therapies. Its main lines of work and hiring cover medicinal chemistry and research science, vivarium operations, clinical supply and trial management, regulatory affairs, quality assurance, franchise analytics, legal contracts, and IT and AI engineering for enterprise platforms.
Backed by Atlas Venture

SUMMARY/JOB PURPOSE (Basic purpose of the job):

The Senior Staff Engineer - Cloud Platform will support the design and creation of cloud-based products and services to meet the technology needs of Exelixis. This position will help define and design our cloud platform, which includes cloud automation tools and standards, CI/CD pipelines, DevOps tooling and AWS account provisioning automation. This position will also work with application support teams to re-define the interface between our cloud platform products and application installation and configuration processes.

ESSENTIAL DUTIES/RESPONSIBILITIES:

Product Strategy & Product Road Map:

  • Develop technical solutions to complex problems which require the regular use of ingenuity and creativity.
  • Understands key business processes and business areas.

Product Development & Delivery:

  • Guides the successful completion of major initiatives or programs and lead mid to large size complex projects.
  • Lead end-to-end development processes, from ideation through CI/CD, security scanning, and production monitoring.
  • Identify and implement improvements to overall processes and development procedures.
  • Develops and applies complex and often long-term strategies on specific projects.
  • Represents the department as the prime technical contact on contracts and projects.
  • Exhibits broad knowledge of state-of-the-art engineering principles and theories.

Stakeholder Management & Cross-Functional Collaboration:

  • Translates overall direction and strategy and communicates across organizational levels and functions.
  • Works on strategic initiatives.
  • Interacts with senior external personnel on significant technical matters often requiring coordination between organizations.

Operational Excellence, Quality & Compliance:

  • Document infrastructure and work instructions for systems and applications, including architecture diagrams, runbooks and code-level commits / READMEs.
  • Lead and own incident response and root cause analysis for high-impact issues.
  • Ensure that completed work delivers long-term value, including the aspects of maintainability, performance and observability.
  • Make decisions regarding access, permissions, and security controls across systems.

Subject Matter Expertise:

  • Serve as the SME for assigned capabilities, providing technical leadership and guidance.
  • Mentor and coach junior engineers, fostering technical growth and best practices.

SUPERVISORY RESPONSIBILITIES:

No supervisory responsibilities.

EDUCATION/EXPERIENCE/KNOWLEDGE & SKILLS:

Education:

  • Master's degree in a relevant field and 7 years of experience; or
  • Bachelor’s degree in a relevant field and 9 years of related experience; or
  • Associate degree and 11 years of experience; or
  • Equivalent combination of education or years of experience
  • Technical certification may be required

Experience:

  • At least 7 years of experience in cloud infrastructure in a highly available and production environment.
  • Experience working in a SOX and FDA regulated environment is a plus.
  • Strong hands-on experience managing and supporting AWS infrastructure, including EC2, VPC, S3, EBS, Route 53, IAM, KMS, load balancing, and Auto Scaling.
  • Strong Infrastructure-as-Code experience using Terraform.
  • Experience developing and maintaining Jenkins CI/CD pipelines.
  • Experience with Ansible for configuration management and infrastructure automation.
  • Proficiency in at least one scripting language such as Python, PowerShell, or Bash, with the ability to develop operational automation.

Knowledge, Skills and Abilities:

  • Advanced level knowledge of Amazon Web Services (AWS), especially with services related to hosting: EC2, RDS, Systems Manager, IAM, etc.
  • Advanced level knowledge with infrastructure as code (IaC) tools, especially Terraform.
  • Intermediate level knowledge with cloud and infrastructure automation.

#LI-EZ1

Location: Alameda, CA Range for this position: $190,000 - $239,500 The base pay offered will take into account job-related knowledge, skills, experience and internal equity, among other factors.In addition to the base salary, as part of our Total Rewards program, Exelixis offers comprehensive employee benefits package, including a 401k plan with generous company contributions, group medical, dental and vision coverage, life and disability insurance, and flexible spending accounts. Employees are also eligible for a discretionary annual bonus program, or if field sales staff, a sales-based incentive plan. Exelixis also offers employees the opportunity to purchase company stock, and receive long-term incentives, 15 accrued vacation days in their first year, 17 paid holidays including a company-wide winter shutdown in December, and up to 10 sick days throughout the calendar year.

Exelixis is an Equal Opportunity Employer. We are committed to fostering an inclusive environment where everyone can thrive. Qualified applicants will receive consideration for employment without regard to race, color, religion, sex, pregnancy (including lactation, childbirth, or related medical conditions), sexual orientation, gender identity, age (40 and over), national origin or ancestry, citizenship or immigration status, physical or mental disability, genetic information (including testing and characteristics), veteran status, uniformed servicemember status, or any other characteristic protected by applicable federal, state, or local law. We are also committed to providing reasonable accommodations to qualified individuals with disabilities, unless undue hardship and/or a direct threat to the health and/or safety of the individual or others would result.

If you have a disability and need an accommodation in relation to the recruiting process, please email us at: [email protected].

Exelixis is an E-Verify employer.

WORKING CONDITIONS:

Our office is a modern space that fosters collaboration and creativity. Teams work closely together, sharing ideas and solutions in a supportive atmosphere. We provide all necessary equipment, including dual monitors and ergonomic chairs, to ensure a comfortable workspace.

DISCLAIMER:

The preceding job description has been designed to indicate the general nature and level of work performed by employees within this classification. It is not designed to contain or be interpreted as a comprehensive inventory of all duties, responsibilities and qualifications required of employees assigned to the job.

We are an Equal Opportunity Employer and do not discriminate against any employee or applicant for employment because of race, color, sex, age, national origin, religion, sexual orientation, gender identity, status as a veteran, and basis of disability or any other federal, state or local protected class.

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