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Salary
≈ $57k – $116k per year (Estimated)
Location
In office (Singapore)
Seniority
Staff · 8+ years exp
Visa
No sponsorship (stated in the posting)
Employment
Full-Time

Confirmed on the employer's own hiring board on Nov 11, 2026. First seen by Alion on Sep 21, 2026. Illumina scores A on the Alion truth index.

Overview
Company
Impact
Profile match
Illumina is an American company founded in 1998 whose sequencing machines drove the cost of reading a human genome from hundreds of millions of dollars to a few hundred, and it holds the dominant share of the market it largely created. Its business is a classic instruments and consumables model: sequencers are sold once and then consume proprietary reagent kits for years, which is where most of the profit sits. Headquartered in San Diego and listed on Nasdaq, it spent years entangled in the forced divestiture of the cancer test maker Grail and now faces genuine competition from Chinese and startup sequencing platforms for the first time.
What if the work you did every day could impact the lives of people you know? Or all of humanity?At Illumina, we are expanding access to genomic technology to realize health equity for billions of people around the world. Our efforts enable life-changing discoveries that are transforming human health through the early detection and diagnosis of diseases and new treatment options for patients.Working at Illumina means being part of something bigger than yourself. Every person, in every role, has the opportunity to make a difference. Surrounded by extraordinary people, inspiring leaders, and world changing projects, you will do more and become more than you ever thought possible.

Staff Mechanical Design Engineer (Sequencing Instrument Platform)

Position Summary

The Staff Mechanical Design Engineer in Illumina’s R&D department will lead and contribute to the development of new, industry-leading genetic analysis platforms for life sciences and clinical markets. The engineer will be responsible for design of DNA sequencing equipment that includes complex optical, mechanical, electrical, chemical, and software sub-systems. The engineer will be responsible for participating in and coordinating cross-functional teams, developing plans, performing analysis, and innovating new technologies.

Job duties and responsibilities include:

  • Uncover product requirements and translate requirements into subsystem specifications.
  • Design precision electro-mechanical and fluidic mechanisms.
  • Work in concurrent, cross-functional teams.
  • Actively seek out and collect input from stakeholders across supporting disciplines.
  • Manage outsourced design and manufacturing relationships.
  • Compare performance and cost of design options in a data driven manner.
  • Perform mechanical and thermal analysis of subsystem / system designs.
  • Create schedules and manage actions to meet milestones.
  • Perform risk analysis, develop test plans, and execute verification testing of subsystems and systems.
  • Follow through on transfer of new products into manufacturing, track issues in manufacturing and the field, and implement resolution of issues.
  • Propose and investigate new architecture, technologies and products that enable the goals of Illumina’s product portfolio.
  • Candidates must thrive in a dynamic environment and place great emphasis on meeting milestones and breaking down barriers to achieve results.
  • Candidate would be required to travel to US for work purposes

All listed tasks and responsibilities are deemed as essential functions to this position; however, business conditions may require reasonable accommodation for additional tasks and responsibilities.

Preferred:

  • Experience in biomedical instruments, biological assays, and/or genetic analysis equipment is preferred.
  • Experience in FDA regulated markets is a plus.

Education and experience:

  • BS/MS/PhD in Mechanical Engineering, Physics, or related and >8 years industry experience.
  • Candidate must have experience in product development, transfer to manufacturing, and documentation.
  • Candidate must have a proven track record in designing robust electro-mechanical systems which may include imaging, dynamic motion control, fluidics components, and thermal control.
  • Demonstrated knowledge of mechanical engineering design principles and practices - Form, fit, tolerance stack analysis, GD&T, drafting standards, FEA, design for assembly, design for manufacturing, etc.
  • Experience with a wide variety of manufacturing processes (low, medium, and high volume).
  • Selection of electromechanical components such as motors, power transmission components and sensors.
  • Evaluation and optimization of complex tolerance budgets.
  • Candidate must have strong project management skills and interpersonal, relationship-building skills.
  • Fluent in SolidWorks CAD software and one or more mechanical FEA packages.

All listed requirements are deemed essential functions to this position; however, business conditions may require reasonable accommodation for additional tasks and responsibilities.

ATTITUDE/ATTRIBUTES:

  • Ability and willingness to make an impact
  • Creativity of thought and mindset
  • Thrives in a dynamic and fast paced environment
  • A passion for discovery

We are a company deeply rooted in belonging, promoting an inclusive environment where employees feel valued and empowered to contribute to our mission. Built on a strong foundation, Illumina has always prioritized openness, collaboration, and seeking alternative perspectives to propel innovation in genomics. We are proud to confirm a zero-net gap in pay, regardless of gender, ethnicity, or race. We also have several Employee Resource Groups (ERG) that deliver career development experiences, increase cultural awareness, and offer opportunities to engage in social responsibility. We are proud to be an equal opportunity employer committed to providing employment opportunity regardless of sex, race, creed, color, gender, religion, marital status, domestic partner status, age, national origin or ancestry, physical or mental disability, medical condition, sexual orientation, pregnancy, military or veteran status, citizenship status, and genetic information. Illumina conducts background checks on applicants for whom a conditional offer of employment has been made. Qualified applicants with arrest or conviction records will be considered for employment in accordance with applicable local, state, and federal laws. Background check results may potentially result in the withdrawal of a conditional offer of employment. The background check process and any decisions made as a result shall be made in accordance with all applicable local, state, and federal laws. Illumina prohibits the use of generative artificial intelligence (AI) in the application and interview process. If you require accommodation to complete the application or interview process, please contact [email protected]. To learn more, visit: https://www.dol.gov/ofccp/regs/compliance/posters/pdf/eeopost.pdf. The position will be posted until a final candidate is selected or the requisition has a sufficient number of qualified applicants. This role is not eligible for visa sponsorship.

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