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Salary
$118k – $177k per year
Location
In office (San Diego)
Seniority
Staff · 8+ years exp
Visa
No sponsorship (stated in the posting)
Employment
Full-Time

Confirmed on the employer's own hiring board on Nov 11, 2026. First seen by Alion on Nov 10, 2026. Illumina scores A on the Alion truth index.

Overview
Company
Impact
Profile match
Illumina is an American company founded in 1998 whose sequencing machines drove the cost of reading a human genome from hundreds of millions of dollars to a few hundred, and it holds the dominant share of the market it largely created. Its business is a classic instruments and consumables model: sequencers are sold once and then consume proprietary reagent kits for years, which is where most of the profit sits. Headquartered in San Diego and listed on Nasdaq, it spent years entangled in the forced divestiture of the cancer test maker Grail and now faces genuine competition from Chinese and startup sequencing platforms for the first time.
What if the work you did every day could impact the lives of people you know? Or all of humanity?At Illumina, we are expanding access to genomic technology to realize health equity for billions of people around the world. Our efforts enable life-changing discoveries that are transforming human health through the early detection and diagnosis of diseases and new treatment options for patients.Working at Illumina means being part of something bigger than yourself. Every person, in every role, has the opportunity to make a difference. Surrounded by extraordinary people, inspiring leaders, and world changing projects, you will do more and become more than you ever thought possible.

This is a unique opportunity for a scientist or engineer who thrives on solving complex problems and driving real-world product performance. As a Staff Product Engineer at Illumina, you'll play a critical role in ensuring the reliability and quality of the consumables that power cutting-edge genomic sequencing around the globe. Working at the intersection of R&D, manufacturing, quality, and customer support, you'll lead high-impact investigations, influence next-generation product development, and drive continuous improvements that directly impact researchers, clinicians, and patients worldwide.

Responsibilities:

  • Work with Process Engineering, Quality, Suppliers and Customer Support to lead investigations and troubleshoot production line issues related to consumable performance
  • Provide technical expertise and leadership to resolve issues
  • Analyze production and QC data, and test results, issues reports, and lend technical guidance
  • Provide analytical data support and product expertise for development teams
  • Work with Quality and product groups to resolve quality and reliability problems with customers
  • In conjunction with R&D, conduct controlled new product optimization tests (including DOEs) and experiments for release into production environment
  • Drive product performance improvements with field performance monitoring and continuous improvement, investigation, leadership, and technical mentoring
  • Assist in defining technical requirements for new products
  • Provide feedback of information to process owners and lead teams to resolve quality issues
  • Recommend and implement new QC techniques where needed
  • Conduct risk assessments for design changes to on market products
  • Collaborate with development teams and subject matter experts to find root cause for on market investigations

Required Background:

  • Strong background in molecular biology, biochemistry, chemical engineering, or equivalent
  • Some experience with the NGS industry, and extensive experience using Illumina sequencing platforms
  • Solid data analysis skills and a logical approach to problem solving
  • High level computer data analysis and statistical knowledge
    • Good interdepartmental communication and documentation skills
    • Successful project management experience
    • Experience in manufacturing support/sustaining and transferring products from R&D to production preferred
    • Experience with Statistical Process Control and DOE techniques
    • Experience with high volume manufacturing in a high-tech, high-volume consumables industry
    • Experience with product development processes and project management

Education:

  • Typically requires a minimum of 8 years of related experience with a Bachelor’s degree; or 6 years and a Master’s degree; or a PhD with 3 years of experience; or equivalent experience.
The estimated base salary range for the Staff Product Engineer role based in the United States of America is: $118,200 - $177,200. Should the level or location of the role change during the hiring process, the applicable base pay range may be updated accordingly. The range reflects long-term growth in the role; therefore, most candidates are hired between the minimum and middle of the range. Placement depends on experience, skills, location, and internal equity. Additionally, all employees are eligible for one of our variable cash programs (bonus or commission) and eligible roles may receive equity as part of the compensation package. We offer a wide range of benefits as innovative as our work, including access to genomics sequencing, family planning, health/dental/vision, retirement benefits, and paid time off.

We are a company deeply rooted in belonging, promoting an inclusive environment where employees feel valued and empowered to contribute to our mission. Built on a strong foundation, Illumina has always prioritized openness, collaboration, and seeking alternative perspectives to propel innovation in genomics. We are proud to confirm a zero-net gap in pay, regardless of gender, ethnicity, or race. We also have several Employee Resource Groups (ERG) that deliver career development experiences, increase cultural awareness, and offer opportunities to engage in social responsibility. We are proud to be an equal opportunity employer committed to providing employment opportunity regardless of sex, race, creed, color, gender, religion, marital status, domestic partner status, age, national origin or ancestry, physical or mental disability, medical condition, sexual orientation, pregnancy, military or veteran status, citizenship status, and genetic information. Illumina conducts background checks on applicants for whom a conditional offer of employment has been made. Qualified applicants with arrest or conviction records will be considered for employment in accordance with applicable local, state, and federal laws. Background check results may potentially result in the withdrawal of a conditional offer of employment. The background check process and any decisions made as a result shall be made in accordance with all applicable local, state, and federal laws. Illumina prohibits the use of generative artificial intelligence (AI) in the application and interview process. If you require accommodation to complete the application or interview process, please contact [email protected]. To learn more, visit: https://www.dol.gov/ofccp/regs/compliance/posters/pdf/eeopost.pdf. The position will be posted until a final candidate is selected or the requisition has a sufficient number of qualified applicants. This role is not eligible for visa sponsorship.

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