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Salary
$75k – $112k per year
Location
In office (San Diego)
Seniority
Junior
Visa
No sponsorship (stated in the posting)
Employment
Full-Time

Confirmed on the employer's own hiring board on Oct 10, 2026. First seen by Alion on Oct 9, 2026. Illumina scores B on the Alion truth index.

Overview
Company
Impact
Profile match
Illumina is an American company founded in 1998 whose sequencing machines drove the cost of reading a human genome from hundreds of millions of dollars to a few hundred, and it holds the dominant share of the market it largely created. Its business is a classic instruments and consumables model: sequencers are sold once and then consume proprietary reagent kits for years, which is where most of the profit sits. Headquartered in San Diego and listed on Nasdaq, it spent years entangled in the forced divestiture of the cancer test maker Grail and now faces genuine competition from Chinese and startup sequencing platforms for the first time.
What if the work you did every day could impact the lives of people you know? Or all of humanity?At Illumina, we are expanding access to genomic technology to realize health equity for billions of people around the world. Our efforts enable life-changing discoveries that are transforming human health through the early detection and diagnosis of diseases and new treatment options for patients.Working at Illumina means being part of something bigger than yourself. Every person, in every role, has the opportunity to make a difference. Surrounded by extraordinary people, inspiring leaders, and world changing projects, you will do more and become more than you ever thought possible.

Position Summary:

As a Systems Support Engineer, you will work in a dynamic, team-oriented environment and help improve genomic analysis tools used in cutting edge research. Working within Illumina’s Systems Engineering and Integration team, you will be responsible for investigating and resolving system-level platform issues and supporting system verification and validation activities for planned platform changes.

Responsibilities:

  • Hands-on testing and integration of systems in a laboratory environment: hardware, software, chemistry, and application components
  • Use mechanical, optical, fluidics, electronics, and chemistry knowledge to troubleshoot system-level sequencing instrument issues
  • Collaborate with all functions within development teams (Engineering, Chemistry Development, Consumables, Software, Field Service, Manufacturing, etc.)
  • Provide product support for pre- and post-launch activities
  • Perform testing and troubleshooting to gather data and make technical recommendations
  • Support investigation experiments and design verification test plans
  • Use of Confluence, Jira, MS 365 and other collaborative software to aid in fleet management, allocation, issue tracking, and other laboratory administrative tasks
  • Occasional travel to support instrumentation builds and troubleshooting

Required Qualifications & Education:

  • BS/MS in Bioengineering, Mechanical Engineering, Systems Engineering, Electrical Engineering, or a related engineering/scientific field OR a BS/MS in an unrelated field with engineering/scientific work experience
  • 0-2+ years engineering/scientific work experience
  • Basic laboratory experience
  • Good data analysis skills and a logical approach to problem solving skills
  • High degree of detail orientation and documentation
  • Root cause analysis methodology and execution

Preferred Skills & Experience:

  • Demonstrated ability to understand and successfully work across multiple disciplines such as engineering, software, and manufacturing highly desired
  • Work experience in biotech or medical device field
  • Understanding of sequencing systems and techniques helpful
  • Solid communication and writing skills
  • Experience with statistical analysis and data analysis programs (JMP, MATLAB, Microsoft Excel)
  • Experience working in regulated environments e.g. CLIA, ISO 13485, cGMP/cGLP, IVD

The estimated base salary range for the Systems Support Engineer 1 role based in the United States of America is: $74,900 - $112,300. Should the level or location of the role change during the hiring process, the applicable base pay range may be updated accordingly. The range reflects long-term growth in the role; therefore, most candidates are hired between the minimum and middle of the range. Placement depends on experience, skills, location, and internal equity. Additionally, all employees are eligible for one of our variable cash programs (bonus or commission) and eligible roles may receive equity as part of the compensation package. We offer a wide range of benefits as innovative as our work, including access to genomics sequencing, family planning, health/dental/vision, retirement benefits, and paid time off.

We are a company deeply rooted in belonging, promoting an inclusive environment where employees feel valued and empowered to contribute to our mission. Built on a strong foundation, Illumina has always prioritized openness, collaboration, and seeking alternative perspectives to propel innovation in genomics. We are proud to confirm a zero-net gap in pay, regardless of gender, ethnicity, or race. We also have several Employee Resource Groups (ERG) that deliver career development experiences, increase cultural awareness, and offer opportunities to engage in social responsibility. We are proud to be an equal opportunity employer committed to providing employment opportunity regardless of sex, race, creed, color, gender, religion, marital status, domestic partner status, age, national origin or ancestry, physical or mental disability, medical condition, sexual orientation, pregnancy, military or veteran status, citizenship status, and genetic information. Illumina conducts background checks on applicants for whom a conditional offer of employment has been made. Qualified applicants with arrest or conviction records will be considered for employment in accordance with applicable local, state, and federal laws. Background check results may potentially result in the withdrawal of a conditional offer of employment. The background check process and any decisions made as a result shall be made in accordance with all applicable local, state, and federal laws. Illumina prohibits the use of generative artificial intelligence (AI) in the application and interview process. If you require accommodation to complete the application or interview process, please contact [email protected]. To learn more, visit: https://www.dol.gov/ofccp/regs/compliance/posters/pdf/eeopost.pdf. The position will be posted until a final candidate is selected or the requisition has a sufficient number of qualified applicants. This role is not eligible for visa sponsorship.

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