Confirmed on the employer's own hiring board on Oct 23, 2026. First seen by Alion on Oct 22, 2026. Institut Curie scores B on the Alion truth index.
Team “Mechanisms of Repression by Polycomb Group Proteins”
Our research team aims to understand the principles that govern gene regulation by the highly conserved family of chromatin modifiers known as Polycomb proteins, from the biochemical to the cellular and organismal levels. We are affiliated with the Institut Curie Research Center’s Genetics and Developmental Biology Unit (Inserm U934/CNRS UMR3215).
https://institut-curie.org/team/margueron
Missions
- Perform CRISPR-based genetic screens coupled to single cell transcriptomics.
- Engineer various stem cell models (iPS, ES) by genome editing and characterize their transcriptomic and epigenomic properties.
- Conduct biochemical studies of novel Polycomb-associated proteins.
- Participate in all common tasks such as equipment maintenance, renewing stocks, student training, etc.
Activities
- Cloning
- Library preparation (RNA-seq, CUT&RUN-seq, etc.)
- Protein expression and purification, protein pulldowns, Western blot
- Maintenance and differentiation of various stem/progenitor cells
- Lentiviral transduction, transfection
- FACS sorting
- Proliferation and differentiation assays
- Interpretation, synthesis and reporting of results
Constraints and risks
- Biosafety level 2 laboratory
- Routine chemical risks

