Senior Machine Learning Engineer
Confirmed on the employer's own hiring board on Oct 16, 2026. First seen by Alion on Jul 29, 2026.
About Plenful
Plenful is on a mission to transform healthcare operations from the inside out. Fresh off our $50M Series B and backed by Notable Capital, Bessemer Venture Partners, TQ Ventures, Susa/Kivu Ventures, and other leading investors, we’re building the category-defining AI automation platform that healthcare teams rely on to operate smarter, faster, and more efficiently. Our technology empowers healthcare operators across hospital and health systems, pharmacies and payors to eliminate manual work, reduce administrative burden, and improve compliance, all while unlocking critical revenue to fund programs for their in-need patient populations.
Built by healthcare operators for healthcare operators, Plenful is driven by a deep understanding of the challenges facing today’s care teams. We’re passionate about equipping healthcare workers with world-class tools that deliver real, measurable impact, and we’re proud to serve 100+ leading health systems, pharmacies, and healthcare organizations across the country. If you’re excited to help shape the future of healthcare, we’d love to meet you. Apply now to join our growing team.
About the Role
We're looking for a Senior Machine Learning Engineer to design, build, and deploy production-grade ML systems that power the next generation of Plenful's AI platform. You'll own the end-to-end lifecycle - from experimentation to production deployment to ongoing model performance.
You'll partner closely with software engineers, product managers, and data teams to build models and intelligent services that automate healthcare workflows, improve operational efficiency, and create great user experiences. This is an engineering-focused role, and your work will directly impact customers.
You'll thrive here if you enjoy solving hard problems with practical engineering solutions, take ownership from idea through production, and balance experimentation with delivering reliable software. We're a fast-moving startup where priorities evolve quickly - you should be energized by that, not worn down by it.
What You'll Do
Design, build, and deploy machine learning models into production
Develop scalable ML pipelines for training, evaluation, monitoring, and inference
Build intelligent services using modern NLP, LLM, classification, recommendation, and prediction techniques where appropriate
Collaborate with Product and Engineering to translate customer problems into ML solutions
Improve model performance through experimentation, feature engineering, and evaluation
Work with structured and unstructured datasets to develop production-ready features
Implement monitoring, observability, and retraining strategies to maintain model quality
Optimize model latency, scalability, and infrastructure costs
Contribute to architecture discussions and engineering best practices
Stay current with advancements in machine learning and AI, and bring practical innovations into our platform
You May Be a Fit If
You have 5+ years of professional software engineering or machine learning engineering experience
You have a Bachelor's degree in Computer Science, Machine Learning, Engineering, Mathematics, or a related technical field (or equivalent practical experience)
You have strong programming experience in Python
You've built and deployed machine learning models into production environments
You have a solid understanding of supervised and unsupervised learning techniques
You're familiar with modern ML infrastructure - classical MLOps (MLflow, Weights & Biases, Airflow) and LLMOps (LangFuse/LangSmith for tracing, Ragas/Braintrust for evaluation, vLLM/BentoML for serving, and a vector database such as Pinecone, Weaviate, or Qdrant for RAG pipelines)
You've built data pipelines using SQL and distributed data processing tools
You're familiar with cloud platforms such as AWS, GCP, or Azure
You've deployed containerized applications using Docker and Kubernetes
You have a strong grasp of software engineering fundamentals - testing, version control, and CI/CD
You communicate well and collaborate easily across technical and non-technical teams
Bonus points if you:
Have worked with Large Language Models (LLMs), retrieval-augmented generation (RAG), embeddings, or agentic AI systems
Have fine-tuned foundation models or worked with prompt engineering techniques
Are familiar with ML infrastructure tools such as MLflow, Weights & Biases, Airflow, Kubeflow, or SageMaker
Have experience with vector databases and semantic search technologies
Have healthcare, pharmacy, or health tech experience
Have worked in a startup or other fast-paced environment
Technologies you'll likely work with: Python, PyTorch, TensorFlow, Scikit-learn, SQL, PostgreSQL, Docker, Kubernetes, AWS, GitHub Actions, REST APIs, vector databases, and LLM APIs (OpenAI, Anthropic, etc.)
Why You'll Love Working Here
Mission-Driven, World-Class Team - Join an exceptional group of professionals aligned around a meaningful mission and committed to making an impact
Opportunities for Growth - Strengthen your expertise through collaboration with experienced, high-performing leaders across the organization
Flexible Hybrid Work Environment - We're remote-first, with meaningful office presence in San Francisco and New York. R&D roles follow a hybrid model, with two days per week in our San Francisco office
Benefits & Perks
Healthcare Coverage - Full medical, dental, and vision insurance for you and participation for your family
401(k) with Company Match - Plenful matches 50% of your first 3% contributed
Equity - Every full-time employee shares in our success
Unlimited PTO - Take the time you need, when you need it
Daily Lunch Stipend - $100/week to cover your midday meals
Wellness Stipend - $100/month to support your health and well-being
Commuter Benefits - $100/month for SF and NYC-based employees
Parental Leave - Paid leave to support growing families