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Salary
≈ $159k – $355k per year (Estimated)
Location
In office (San Francisco, London, Cambridge)
Visa
Sponsorship offered in the posting
Employment
Full-Time

Confirmed on the employer's own hiring board on Oct 30, 2026. First seen by Alion on Jul 6, 2026. Dayhoff Labs scores B on the Alion truth index.

Overview
Company
Impact
Profile match
Dayhoff Labs is a technology company that builds foundational AI models to solve major challenges in chemistry and biochemistry.

About us

We're reverse-engineering the origin of life - one of the great unsolved problems in science, and one we think AI finally makes tractable. Understanding this transition, from geochemistry to biochemistry, is what will let us orchestrate molecular networks and build systems that are more capable, adaptive, and efficient.

If we succeed, the applications are vast: catalysis, green synthesis, ab initio synthetic biology, programmable matter. Understanding and harnessing these processes could let ten billion of us thrive on this planet - and let life keep evolving beyond it.

We're a small, diverse team of AI engineers, computational scientists, and bench scientists. We hold ourselves to the rigor of a research institute, but we ship like an engineering firm. Global team, HQs in Cambridge, MA and London, UK.

The role

You'll be a generalist research engineer, moving fluidly across our maintenance and research projects wherever leverage is highest. The through-line is using LLMs and agents to build software and complex systems - including for open-ended scientific questions, not just engineering ones. You'll have real latitude to decide what to build and how, and your work will land directly on how fast our researchers move and what our science can do.

What you'll do

  • Use LLMs and coding agents to build software and complex systems, and keep advancing the internal agentic systems we use to write our code and maintain our infrastructure

  • Self-host and evaluate open-source models, and write the harnesses, tooling, and scaffolding that make agents reliable for our workflows

  • Apply agents to scientific questions - an open-ended remit spanning genuine research, experimentation, and analysis, not only software development

  • Contribute across a variety of maintenance and research projects as priorities shift, from internal tooling to data and model work

  • Keep our cloud infrastructure and development environments healthy

Essential experience

  • Demonstrated ability to use LLMs to write software and build complex systems

  • Hands-on experience with open-source models: self-hosting, evaluation, and writing harnesses or scaffolding around them

  • Strong Python and the ability to own complex technical systems end to end

  • Comfort working across an unfamiliar codebase and shipping in areas outside your prior expertise

  • Sound engineering fundamentals: version control workflows, testing, and reproducible environments

Highly preferred

  • Background in biology, chemistry, or a related scientific domain

  • Scientific computing or ML/research-tooling experience

  • Substantial professional software engineering experience

  • Experience building or operating agentic systems (multi-step tool use, orchestration, evaluation harnesses)

  • Familiarity with cloud infrastructure (AWS or GCP), containerization, and infrastructure-as-code

Logistics

Compensation is highly competitive. We're also able to sponsor visas for the right candidate.

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