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Salary
$156k – $233k per year
Location
Remote (United States)
Seniority
Staff · 8+ years exp
Visa
No sponsorship (stated in the posting)
Employment
Full-Time

Confirmed on the employer's own hiring board on Nov 6, 2026. First seen by Alion on Sep 15, 2026. Illumina scores A on the Alion truth index.

Overview
Company
Impact
Profile match
Illumina is an American company founded in 1998 whose sequencing machines drove the cost of reading a human genome from hundreds of millions of dollars to a few hundred, and it holds the dominant share of the market it largely created. Its business is a classic instruments and consumables model: sequencers are sold once and then consume proprietary reagent kits for years, which is where most of the profit sits. Headquartered in San Diego and listed on Nasdaq, it spent years entangled in the forced divestiture of the cancer test maker Grail and now faces genuine competition from Chinese and startup sequencing platforms for the first time.
What if the work you did every day could impact the lives of people you know? Or all of humanity?At Illumina, we are expanding access to genomic technology to realize health equity for billions of people around the world. Our efforts enable life-changing discoveries that are transforming human health through the early detection and diagnosis of diseases and new treatment options for patients.Working at Illumina means being part of something bigger than yourself. Every person, in every role, has the opportunity to make a difference. Surrounded by extraordinary people, inspiring leaders, and world changing projects, you will do more and become more than you ever thought possible.

Responsibilities:

  • Collaborate with product owners and other application developers to design, code, and maintain high quality, cloud-based applications against established processes in a scrum team setting
  • Work with software teams to ensure alignment of architecture to user requirements
  • Occasionally provide technical assistance to escalated production issues
  • Maintain awareness of industry trends and evaluate applicability of new software technologies to platform development efforts
  • Provide technical leadership to an Agile team if required
  • Lead performance optimization efforts, including memory management, parallelization, and algorithm efficiency.

Requirements:

  • Typically requires a minimum of 8 years of related experience with a Bachelor’s degree; or 6 years and a Master’s degree; or a PhD with 3 years of experience; or equivalent experience.

  • Strong proficiency in one or more low-level programming languages, such as C++ or Rust, with a deep understanding of language internals, performance optimization, and memory management

  • Experience with SaaS multitenant database architectures using RDBMS, and noSQL stores such as Elastic Search, Cassendra, and MongoDb

  • Deep understanding of SOA, web security architecture, REST APIs, event-driven architecture, and other architectural patterns

  • Experience with client-side MVC Frameworks (i.e., AngularJS, KnockoutJS) is a plus

  • Proficient with source control management repositories (such as GIT, SVN, etc.) and CM practices

  • Extensive experience writing high quality unit tests against mock objects

  • Good understanding of object oriented analysis and design

  • Demonstrated success in collaborating in a fast-paced team environment and delivering high-quality software products using established agile development methodologies (such as Scrum, Kanban, etc.) against formal schedules

Desired:

  • Possess proven troubleshooting skills. Experience debugging complex issues using low-level debugging and profiling tools (e.g., GDB, LLDB, perf, Valgrind, or equivalent).
  • Be curious, detail oriented, and analytical, with a proven ability to learn quickly
  • Be customer-focused, team-oriented, and motivated, taking ownership of assigned tasks
  • Have proven ability to self-manage, as well as manage interdisciplinary relationships
  • Have proven verbal and written communication skills
The estimated base salary range for the Staff Software Engineer role based in the United States of America is: $155,600 - $233,400. Should the level or location of the role change during the hiring process, the applicable base pay range may be updated accordingly. The range reflects long-term growth in the role; therefore, most candidates are hired between the minimum and middle of the range. Placement depends on experience, skills, location, and internal equity. Additionally, all employees are eligible for one of our variable cash programs (bonus or commission) and eligible roles may receive equity as part of the compensation package. We offer a wide range of benefits as innovative as our work, including access to genomics sequencing, family planning, health/dental/vision, retirement benefits, and paid time off.

We are a company deeply rooted in belonging, promoting an inclusive environment where employees feel valued and empowered to contribute to our mission. Built on a strong foundation, Illumina has always prioritized openness, collaboration, and seeking alternative perspectives to propel innovation in genomics. We are proud to confirm a zero-net gap in pay, regardless of gender, ethnicity, or race. We also have several Employee Resource Groups (ERG) that deliver career development experiences, increase cultural awareness, and offer opportunities to engage in social responsibility. We are proud to be an equal opportunity employer committed to providing employment opportunity regardless of sex, race, creed, color, gender, religion, marital status, domestic partner status, age, national origin or ancestry, physical or mental disability, medical condition, sexual orientation, pregnancy, military or veteran status, citizenship status, and genetic information. Illumina conducts background checks on applicants for whom a conditional offer of employment has been made. Qualified applicants with arrest or conviction records will be considered for employment in accordance with applicable local, state, and federal laws. Background check results may potentially result in the withdrawal of a conditional offer of employment. The background check process and any decisions made as a result shall be made in accordance with all applicable local, state, and federal laws. Illumina prohibits the use of generative artificial intelligence (AI) in the application and interview process. If you require accommodation to complete the application or interview process, please contact [email protected]. To learn more, visit: https://www.dol.gov/ofccp/regs/compliance/posters/pdf/eeopost.pdf. The position will be posted until a final candidate is selected or the requisition has a sufficient number of qualified applicants. This role is not eligible for visa sponsorship.

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